Entry | Database: PDB / ID: 8bjk |
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Title | X-ray structure of Danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with an inhibitor CPD11352 |
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Components | Histone deacetylase 6 |
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Keywords | HYDROLASE / HISTONE DEACETYLASE / DEACETYLATION / INHIBITOR / DANIO RERIO |
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Function / homology | Function and homology information
Aggrephagy / tubulin deacetylase activity / swimming behavior / definitive hemopoiesis / protein lysine deacetylase activity / regulation of tubulin deacetylation / histone deacetylase activity / potassium ion binding / histone deacetylase complex / hematopoietic progenitor cell differentiation ...Aggrephagy / tubulin deacetylase activity / swimming behavior / definitive hemopoiesis / protein lysine deacetylase activity / regulation of tubulin deacetylation / histone deacetylase activity / potassium ion binding / histone deacetylase complex / hematopoietic progenitor cell differentiation / angiogenesis / negative regulation of transcription by RNA polymerase II / zinc ion bindingSimilarity search - Function Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger / Zinc finger, UBP-type / Zn-finger in ubiquitin-hydrolases and other protein / Zinc finger UBP-type profile. / Histone deacetylase family / Histone deacetylase domain / Histone deacetylase domain superfamily / Histone deacetylase domain / Ureohydrolase domain superfamily / Zinc finger, RING/FYVE/PHD-typeSimilarity search - Domain/homology |
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Biological species | ![](img/tx_fish.gif) Danio rerio (zebrafish) |
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Method | X-RAY DIFFRACTION / FOURIER SYNTHESIS / Resolution: 1.35 Å |
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Authors | Barinka, C. / Motlova, L. / Pavlicek, J. |
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Funding support | 1items Organization | Grant number | Country |
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Not funded | | |
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Citation | Journal: Acs Chem.Biol. / Year: 2023 Title: Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6). Authors: Motlova, L. / Snajdr, I. / Kutil, Z. / Andris, E. / Ptacek, J. / Novotna, A. / Novakova, Z. / Havlinova, B. / Tueckmantel, W. / Draberova, H. / Majer, P. / Schutkowski, M. / Kozikowski, A. / ...Authors: Motlova, L. / Snajdr, I. / Kutil, Z. / Andris, E. / Ptacek, J. / Novotna, A. / Novakova, Z. / Havlinova, B. / Tueckmantel, W. / Draberova, H. / Majer, P. / Schutkowski, M. / Kozikowski, A. / Rulisek, L. / Barinka, C. |
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History | Deposition | Nov 4, 2022 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Sep 6, 2023 | Provider: repository / Type: Initial release |
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