- PDB-8bem: STE20-like serine/threonine-protein kinase (SLK) in complex with ... -
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基本情報
登録情報
データベース: PDB / ID: 8bem
タイトル
STE20-like serine/threonine-protein kinase (SLK) in complex with Tivozanib
要素
STE20-like serine/threonine-protein kinase
キーワード
TRANSFERASE / Kinase / Typ II inhibitor / SLK / Tivozanib
機能・相同性
機能・相同性情報
regulation of focal adhesion assembly / RHOB GTPase cycle / RHOC GTPase cycle / cell leading edge / RHOA GTPase cycle / cytoplasmic microtubule organization / regulation of cell migration / regulation of apoptotic process / protein autophosphorylation / non-specific serine/threonine protein kinase ...regulation of focal adhesion assembly / RHOB GTPase cycle / RHOC GTPase cycle / cell leading edge / RHOA GTPase cycle / cytoplasmic microtubule organization / regulation of cell migration / regulation of apoptotic process / protein autophosphorylation / non-specific serine/threonine protein kinase / cadherin binding / protein serine kinase activity / protein serine/threonine kinase activity / apoptotic process / perinuclear region of cytoplasm / protein homodimerization activity / extracellular exosome / ATP binding / identical protein binding / cytoplasm / cytosol 類似検索 - 分子機能
Polo kinase kinase / Polo kinase kinase / UVR domain / UVR domain profile. / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. ...Polo kinase kinase / Polo kinase kinase / UVR domain / UVR domain profile. / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性
解像度: 2.6→48.73 Å / Cor.coef. Fo:Fc: 0.931 / Cor.coef. Fo:Fc free: 0.911 / WRfactor Rfree: 0.2449 / WRfactor Rwork: 0.213 / FOM work R set: 0.7906 / SU B: 24.644 / SU ML: 0.244 / SU R Cruickshank DPI: 0.5243 / SU Rfree: 0.2927 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R: 0.524 / ESU R Free: 0.295 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : WITH TLS ADDED
Rfactor
反射数
%反射
Selection details
Rfree
0.2551
2391
5 %
RANDOM
Rwork
0.2219
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obs
0.2236
45795
99.08 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK