Entry Database : PDB / ID : 8b10 Structure visualization Downloads & linksTitle Crystal Structure of Shank2-SAM mutant domain - L1800W ComponentsSH3 and multiple ankyrin repeat domains protein 2 Details Keywords METAL BINDING PROTEIN / synaptic scaffold protein / Zn2+ binding / Zn-dependent polymerizationFunction / homology Function and homology informationFunction Domain/homology Component
synaptic receptor adaptor activity / : / structural constituent of postsynaptic density / vocalization behavior / Neurexins and neuroligins / anchoring junction / long-term synaptic depression / ciliary membrane / adult behavior / regulation of synapse organization ... synaptic receptor adaptor activity / : / structural constituent of postsynaptic density / vocalization behavior / Neurexins and neuroligins / anchoring junction / long-term synaptic depression / ciliary membrane / adult behavior / regulation of synapse organization / negative regulation of hippo signaling / presynaptic active zone / associative learning / social behavior / photoreceptor outer segment / synapse assembly / hippocampal mossy fiber to CA3 synapse / photoreceptor inner segment / adult locomotory behavior / response to nutrient / learning / long-term synaptic potentiation / brush border membrane / ionotropic glutamate receptor binding / brain development / SH3 domain binding / growth cone / dendritic spine / postsynaptic density / response to xenobiotic stimulus / neuron projection / apical plasma membrane / neuronal cell body / glutamatergic synapse / positive regulation of cell population proliferation / plasma membrane / cytosol Similarity search - Function PDZ domain 6 / PDZ domain / Variant SH3 domain / SAM domain (Sterile alpha motif) / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. ... PDZ domain 6 / PDZ domain / Variant SH3 domain / SAM domain (Sterile alpha motif) / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / Ankyrin repeats (3 copies) / PDZ superfamily / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.95 Å DetailsAuthors Bento, I. / Gracia Alai, M. / Kreienkamp, J.-H. Funding support Germany, 1items Details Hide detailsOrganization Grant number Country German Research Foundation (DFG) Kr1321/9-1 Germany
CitationJournal : Mol Psychiatry / Year : 2022Title : Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans.Authors: Hassani Nia, F. / Woike, D. / Bento, I. / Niebling, S. / Tibbe, D. / Schulz, K. / Hirnet, D. / Skiba, M. / Honck, H.H. / Veith, K. / Gunther, C. / Scholz, T. / Bierhals, T. / Driemeyer, J. / ... Authors : Hassani Nia, F. / Woike, D. / Bento, I. / Niebling, S. / Tibbe, D. / Schulz, K. / Hirnet, D. / Skiba, M. / Honck, H.H. / Veith, K. / Gunther, C. / Scholz, T. / Bierhals, T. / Driemeyer, J. / Bend, R. / Failla, A.V. / Lohr, C. / Alai, M.G. / Kreienkamp, H.J. History Deposition Sep 8, 2022 Deposition site : PDBE / Processing site : PDBERevision 1.0 Nov 30, 2022 Provider : repository / Type : Initial releaseRevision 1.1 Dec 14, 2022 Group : Database references / Category : citation / citation_authorItem : _citation.journal_abbrev / _citation.journal_id_ISSN ... _citation.journal_abbrev / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name Revision 1.2 Jan 31, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / pdbx_initial_refinement_model Item : _citation.country
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