[English] 日本語
Yorodumi
- PDB-8as0: PD-1 extracellular domain in complex with Fab fragment from D12 a... -

+
Open data


ID or keywords:

Loading...

-
Basic information

Entry
Database: PDB / ID: 8as0
TitlePD-1 extracellular domain in complex with Fab fragment from D12 antibody
Components
  • (D12 antibody ...) x 2
  • Programmed cell death protein 1
KeywordsANTITUMOR PROTEIN / Monoclonal antibodies / phage display technology / antibody library / human PD-1 / immunotherapy
Function / homology
Function and homology information


negative regulation of tolerance induction / regulatory T cell apoptotic process / negative regulation of immune response / negative regulation of T cell mediated immune response to tumor cell / negative regulation of T cell activation / B cell apoptotic process / positive regulation of T cell apoptotic process / negative regulation of B cell apoptotic process / humoral immune response / Co-inhibition by PD-1 ...negative regulation of tolerance induction / regulatory T cell apoptotic process / negative regulation of immune response / negative regulation of T cell mediated immune response to tumor cell / negative regulation of T cell activation / B cell apoptotic process / positive regulation of T cell apoptotic process / negative regulation of B cell apoptotic process / humoral immune response / Co-inhibition by PD-1 / regulation of immune response / signaling receptor activity / adaptive immune response / Potential therapeutics for SARS / external side of plasma membrane / apoptotic process / plasma membrane
Similarity search - Function
Programmed cell death protein 1 / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold ...Programmed cell death protein 1 / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta
Similarity search - Domain/homology
Programmed cell death protein 1
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.5 Å
AuthorsOngaro, T. / Scietti, L. / Pluss, L. / Peissert, F. / Villa, A. / Puca, E. / De Luca, R. / Neri, D. / Forneris, F.
Funding support Italy, United States, 3items
OrganizationGrant numberCountry
Italian Association for Cancer ResearchMFAG 20075 Italy
The Giovanni Armenise-Harvard FoundationCDA 2013 United States
Ministero dell Universita e della RicercaDipartimenti di eccellenza 2018-2022 Italy
CitationJournal: Protein Sci. / Year: 2022
Title: Selection of a PD-1 blocking antibody from a novel fully human phage display library.
Authors: Peissert, F. / Pluss, L. / Giudice, A.M. / Ongaro, T. / Villa, A. / Elsayed, A. / Nadal, L. / Dakhel Plaza, S. / Scietti, L. / Puca, E. / De Luca, R. / Forneris, F. / Neri, D.
History
DepositionAug 17, 2022Deposition site: PDBE / Processing site: PDBE
Revision 1.0Nov 23, 2022Provider: repository / Type: Initial release
Revision 1.1Dec 7, 2022Group: Database references / Category: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID / _citation_author.name
Revision 1.2Dec 21, 2022Group: Database references / Category: citation / citation_author
Item: _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID
Revision 1.3Jan 31, 2024Group: Data collection / Refinement description
Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
Revision 1.4Oct 23, 2024Group: Structure summary / Category: pdbx_entry_details / pdbx_modification_feature / Item: _pdbx_entry_details.has_protein_modification

-
Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

-
Assembly

Deposited unit
C: D12 antibody light chain, Fab fragment
B: D12 antibody heavy chain, Fab fragment
A: Programmed cell death protein 1
D: D12 antibody light chain, Fab fragment
E: D12 antibody heavy chain, Fab fragment
F: Programmed cell death protein 1
G: D12 antibody light chain, Fab fragment
H: D12 antibody heavy chain, Fab fragment
I: Programmed cell death protein 1
J: D12 antibody light chain, Fab fragment
K: D12 antibody heavy chain, Fab fragment
L: Programmed cell death protein 1
M: D12 antibody light chain, Fab fragment
N: D12 antibody heavy chain, Fab fragment
O: Programmed cell death protein 1
P: D12 antibody light chain, Fab fragment
Q: D12 antibody heavy chain, Fab fragment
R: Programmed cell death protein 1
V: D12 antibody light chain, Fab fragment
W: D12 antibody heavy chain, Fab fragment
X: Programmed cell death protein 1
S: D12 antibody light chain, Fab fragment
T: D12 antibody heavy chain, Fab fragment
Y: Programmed cell death protein 1
hetero molecules


Theoretical massNumber of molelcules
Total (without water)539,78745
Polymers529,67724
Non-polymers10,10921
Water00
1
C: D12 antibody light chain, Fab fragment
B: D12 antibody heavy chain, Fab fragment
A: Programmed cell death protein 1
hetero molecules


Theoretical massNumber of molelcules
Total (without water)67,5135
Polymers66,2103
Non-polymers1,3032
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
D: D12 antibody light chain, Fab fragment
E: D12 antibody heavy chain, Fab fragment
F: Programmed cell death protein 1
hetero molecules


Theoretical massNumber of molelcules
Total (without water)67,5886
Polymers66,2103
Non-polymers1,3783
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
3
G: D12 antibody light chain, Fab fragment
H: D12 antibody heavy chain, Fab fragment
I: Programmed cell death protein 1
hetero molecules


Theoretical massNumber of molelcules
Total (without water)67,3696
Polymers66,2103
Non-polymers1,1593
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
4
J: D12 antibody light chain, Fab fragment
K: D12 antibody heavy chain, Fab fragment
L: Programmed cell death protein 1
hetero molecules


Theoretical massNumber of molelcules
Total (without water)67,7096
Polymers66,2103
Non-polymers1,4993
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
5
M: D12 antibody light chain, Fab fragment
N: D12 antibody heavy chain, Fab fragment
O: Programmed cell death protein 1
hetero molecules


Theoretical massNumber of molelcules
Total (without water)67,1645
Polymers66,2103
Non-polymers9542
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
6
P: D12 antibody light chain, Fab fragment
Q: D12 antibody heavy chain, Fab fragment
R: Programmed cell death protein 1
hetero molecules


Theoretical massNumber of molelcules
Total (without water)67,1645
Polymers66,2103
Non-polymers9542
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
7
V: D12 antibody light chain, Fab fragment
W: D12 antibody heavy chain, Fab fragment
X: Programmed cell death protein 1
hetero molecules


Theoretical massNumber of molelcules
Total (without water)67,8966
Polymers66,2103
Non-polymers1,6873
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
8
S: D12 antibody light chain, Fab fragment
T: D12 antibody heavy chain, Fab fragment
Y: Programmed cell death protein 1
hetero molecules


Theoretical massNumber of molelcules
Total (without water)67,3856
Polymers66,2103
Non-polymers1,1753
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)81.195, 187.092, 190.845
Angle α, β, γ (deg.)90.00, 90.24, 90.00
Int Tables number4
Space group name H-MP1211

-
Components

-
Protein , 1 types, 8 molecules AFILORXY

#3: Protein
Programmed cell death protein 1 / Protein PD-1 / hPD-1


Mass: 19073.203 Da / Num. of mol.: 8
Source method: isolated from a genetically manipulated source
Details: expression tag at C-terminus: GLNDIFEAQKIEWHEHHHHHH
Source: (gene. exp.) Homo sapiens (human) / Gene: PDCD1, PD1 / Cell line (production host): CHO / Production host: Cricetulus griseus (Chinese hamster) / References: UniProt: Q15116

-
Antibody , 2 types, 16 molecules CDGJMPVSBEHKNQWT

#1: Antibody
D12 antibody light chain, Fab fragment


Mass: 23343.863 Da / Num. of mol.: 8
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Cell line: AMG phage library / Cell line (production host): CHO / Production host: Cricetulus griseus (Chinese hamster)
#2: Antibody
D12 antibody heavy chain, Fab fragment


Mass: 23792.594 Da / Num. of mol.: 8
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Cell line: AMG phage library / Cell line (production host): CHO / Production host: Cricetulus griseus (Chinese hamster)

-
Sugars , 8 types, 21 molecules

#4: Polysaccharide alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1- ...alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 748.682 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
DescriptorTypeProgram
DManpa1-3DManpb1-4DGlcpNAcb1-4DGlcpNAcb1-Glycam Condensed SequenceGMML 1.0
WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3/a4-b1_b4-c1_c3-d1WURCSPDB2Glycan 1.1.0
[]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{[(3+1)][a-D-Manp]{}}}}}LINUCSPDB-CARE
#5: Polysaccharide
beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1- ...beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 732.682 Da / Num. of mol.: 4 / Source method: obtained synthetically
DescriptorTypeProgram
DManpb1-4DGlcpNAcb1-4[LFucpa1-6]DGlcpNAcb1-Glycam Condensed SequenceGMML 1.0
WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1221m-1a_1-5]/1-1-2-3/a4-b1_a6-d1_b4-c1WURCSPDB2Glycan 1.1.0
[]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{}}[(6+1)][a-L-Fucp]{}}}LINUCSPDB-CARE
#6: Polysaccharide 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta- ...2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 570.542 Da / Num. of mol.: 3 / Source method: obtained synthetically
DescriptorTypeProgram
DGlcpNAcb1-4[LFucpa1-6]DGlcpNAcb1-Glycam Condensed SequenceGMML 1.0
WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-1-2/a4-b1_a6-c1WURCSPDB2Glycan 1.1.0
[]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}[(6+1)][a-L-Fucp]{}}}LINUCSPDB-CARE
#7: Polysaccharide 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 424.401 Da / Num. of mol.: 1 / Source method: obtained synthetically
DescriptorTypeProgram
DGlcpNAcb1-4DGlcpNAcb1-Glycam Condensed SequenceGMML 1.0
WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1WURCSPDB2Glycan 1.1.0
[]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}}}LINUCSPDB-CARE
#8: Polysaccharide beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1- ...beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 732.682 Da / Num. of mol.: 1 / Source method: obtained synthetically
DescriptorTypeProgram
DManpb1-3DGlcpNAcb1-4[LFucpa1-6]DGlcpNAcb1-Glycam Condensed SequenceGMML 1.0
WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1221m-1a_1-5]/1-1-2-3/a4-b1_a6-d1_b3-c1WURCSPDB2Glycan 1.1.0
[]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(3+1)][b-D-Manp]{}}[(6+1)][a-L-Fucp]{}}}LINUCSPDB-CARE
#9: Polysaccharide alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 367.349 Da / Num. of mol.: 2 / Source method: obtained synthetically
DescriptorTypeProgram
LFucpa1-6DGlcpNAcb1-Glycam Condensed SequenceGMML 1.0
WURCS=2.0/2,2,1/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-2/a6-b1WURCSPDB2Glycan 1.1.0
[]{[(4+1)][b-D-GlcpNAc]{[(6+1)][a-L-Fucp]{}}}LINUCSPDB-CARE
#10: Polysaccharide alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-3)-2-acetamido-2- ...alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 1056.964 Da / Num. of mol.: 1 / Source method: obtained synthetically
DescriptorTypeProgram
DManpa1-3[DManpa1-6]DManpb1-3DGlcpNAcb1-4[LFucpa1-6]DGlcpNAcb1-Glycam Condensed SequenceGMML 1.0
WURCS=2.0/4,6,5/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5][a1221m-1a_1-5]/1-1-2-3-3-4/a4-b1_a6-f1_b3-c1_c3-d1_c6-e1WURCSPDB2Glycan 1.1.0
[]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(3+1)][b-D-Manp]{[(3+1)][a-D-Manp]{}[(6+1)][a-D-Manp]{}}}[(6+1)][a-L-Fucp]{}}}LINUCSPDB-CARE
#11: Sugar
ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 8 / Source method: obtained synthetically / Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

-
Details

Has ligand of interestN
Has protein modificationY

-
Experimental details

-
Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

-
Sample preparation

CrystalDensity Matthews: 3.04 Å3/Da / Density % sol: 59.55 %
Crystal growTemperature: 293 K / Method: vapor diffusion, hanging drop / pH: 4.5 / Details: 22% PEG 3350, 250 mM sodium malonate, pH 4.5

-
Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: ESRF / Beamline: MASSIF-1 / Wavelength: 0.965 Å
DetectorType: DECTRIS PILATUS3 2M / Detector: PIXEL / Date: Jul 1, 2021
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.965 Å / Relative weight: 1
ReflectionResolution: 3.5→190.84 Å / Num. obs: 68755 / % possible obs: 96.1 % / Redundancy: 1.7 % / CC1/2: 0.94 / Rmerge(I) obs: 0.141 / Rpim(I) all: 0.1 / Net I/σ(I): 3.9
Reflection shellResolution: 3.5→3.58 Å / Redundancy: 1.8 % / Rmerge(I) obs: 0.642 / Num. unique obs: 4708 / CC1/2: 0.431 / Rpim(I) all: 0.431 / % possible all: 97.6

-
Processing

Software
NameVersionClassification
PHENIX(1.20_4459: ???)refinement
XDSdata reduction
Aimlessdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 5WT9, Alphafold2

5wt9


Resolution: 3.5→95.42 Å / SU ML: 0.54 / Cross valid method: FREE R-VALUE / σ(F): 1.36 / Phase error: 30.15 / Stereochemistry target values: ML
RfactorNum. reflection% reflection
Rfree0.2926 3524 5.13 %
Rwork0.2431 --
obs0.2456 68677 95.63 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL
Refinement stepCycle: LAST / Resolution: 3.5→95.42 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms33488 0 36 0 33524
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00434279
X-RAY DIFFRACTIONf_angle_d0.746582
X-RAY DIFFRACTIONf_dihedral_angle_d4.935015
X-RAY DIFFRACTIONf_chiral_restr0.0675363
X-RAY DIFFRACTIONf_plane_restr0.0075926
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
3.5-3.550.38061270.32912673X-RAY DIFFRACTION97
3.55-3.60.34681680.32192595X-RAY DIFFRACTION97
3.6-3.650.37061400.31932664X-RAY DIFFRACTION97
3.65-3.710.36161870.32562599X-RAY DIFFRACTION97
3.71-3.770.37161130.31472654X-RAY DIFFRACTION98
3.77-3.840.34491290.30192686X-RAY DIFFRACTION98
3.84-3.910.37881490.30922592X-RAY DIFFRACTION96
3.91-3.980.29251460.28282620X-RAY DIFFRACTION97
3.98-4.060.30221150.27482673X-RAY DIFFRACTION96
4.06-4.150.31591390.26482582X-RAY DIFFRACTION96
4.15-4.250.30171340.24522681X-RAY DIFFRACTION97
4.25-4.350.29041090.23422609X-RAY DIFFRACTION97
4.35-4.470.28881980.22562563X-RAY DIFFRACTION96
4.47-4.60.25871330.2162462X-RAY DIFFRACTION91
4.6-4.750.24131710.21022518X-RAY DIFFRACTION93
4.75-4.920.2791310.21252580X-RAY DIFFRACTION96
4.92-5.120.27161570.21222679X-RAY DIFFRACTION98
5.12-5.350.26381660.21432617X-RAY DIFFRACTION97
5.35-5.630.29151630.22132594X-RAY DIFFRACTION96
5.63-5.980.30861610.22662589X-RAY DIFFRACTION96
5.98-6.450.26411360.23322631X-RAY DIFFRACTION96
6.45-7.090.2904960.2522629X-RAY DIFFRACTION94
7.1-8.120.28391420.21882601X-RAY DIFFRACTION94
8.12-10.230.2345830.18532533X-RAY DIFFRACTION91
10.23-95.420.24951310.21972529X-RAY DIFFRACTION90
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
11.45741.47470.54062.76680.55493.18540.2780.288-0.3248-0.4366-0.21520.56350.2962-1.18761.56240.7269-0.1012-0.10180.9663-0.73011.0787-1.237728.208222.7826
22.3555-0.4643-0.04642.24880.87921.7339-0.70250.02420.0721-0.0337-0.08090.5694-0.0806-0.4574-0.25620.4306-0.10420.27220.5626-0.24440.72247.805425.823625.7336
32.1160.4183-0.88770.107-0.04981.2003-0.18680.4813-0.7622-0.2537-0.6326-0.45540.1401-0.026-0.29130.1406-0.28080.25651.3683-0.1350.74529.283339.76125.5874
40.81680.0102-0.27610.97410.10190.0909-1.09360.7245-0.4962-0.30870.94360.61320.28140.32820.12130.7139-0.47310.47851.0578-0.35221.3858-9.503916.550334.4069
52.88742.12833.93553.92631.96926.93860.73820.191-0.1606-0.23440.8228-0.50010.02490.04040.39030.284-0.01930.16090.64280.19411.0754-14.976622.850963.603
65.6831.38860.10311.05560.48964.4153-0.56910.84330.2647-0.25790.2650.3655-0.2679-0.57110.03480.6275-0.0491-0.0190.5766-0.05060.6789-19.57623.956249.9661
73.06482.09930.90391.45660.85183.175-0.7080.3769-0.7559-0.2147-0.1506-0.82440.111-0.1765-1.47441.1526-0.48880.26010.8382-0.52191.2232-5.428916.546440.7105
81.71281.08351.36292.65020.35454.83280.1291-0.55870.56070.34660.02910.3716-0.3029-0.75470.56260.7053-0.18670.2578-0.3629-0.28170.684-23.096525.805659.404
91.0819-0.3739-0.3962.6005-0.48292.4818-1.07731.0799-0.2710.41250.0156-0.66360.6661-0.9368-0.40860.6324-0.2527-0.03810.9501-0.25770.8686-24.329115.353753.216
103.6493-0.8182-0.66930.3635-0.05194.0685-0.8068-1.1085-0.66670.62330.98590.34140.26390.04970.07520.531-0.01960.04720.4474-0.06130.659812.568337.729547.9209
115.6846-1.8649-2.60024.4081-0.91063.0138-0.2614-0.7527-0.3011.2028-0.2745-0.44250.66360.6926-0.95310.38260.05650.19790.8399-0.26340.722419.196737.54440.6815
122.28050.493-1.25330.6360.20873.5867-0.1410.41890.2084-0.0076-0.0157-0.7197-0.6463-0.40820.08990.3653-0.2928-0.09780.2547-0.02850.738912.846545.520135.2669
131.54180.183-1.16120.62150.61263.10320.28440.23070.8153-0.72910.1196-0.4740.3819-0.48-0.02110.6445-0.21590.13660.1972-0.16050.706716.332345.211943.9291
143.70930.5174-0.9111.48732.45286.73820.5455-0.0386-0.4620.3024-0.5193-0.48580.6493-0.54180.77530.41280.04270.05470.1447-0.22450.890115.451233.961234.9042
151.20460.86770.40651.07470.81061.01170.32060.0213-0.35181.0461-0.15680.13420.224-0.2494-0.15320.46810.167-0.02270.3944-0.00690.7718-4.596229.496458.3947
161.3181-0.5651-0.51631.57360.02980.77410.3038-0.2504-0.88040.4312-0.5401-0.4582-0.0652-0.04630.19560.52210.11150.18920.47240.12511.14581.011422.128254.5647
171.1268-0.58091.0388.3820.80361.5385-0.33980.151-0.684-0.5747-0.8754-0.19520.45310.2769-0.42050.3332-0.17210.09480.57220.2680.7565-9.034234.045252.9794
180.0735-0.42030.14853.1918-0.54380.59920.071-0.5532-0.32790.2074-0.8437-0.30980.00240.36670.16210.44860.0055-0.10950.74560.1881.1235-2.091819.416461.4673
194.53040.1204-1.66061.08061.10764.2162-0.7917-0.76010.53580.32840.67910.1211-0.1140.4965-0.02580.91120.06130.19860.3416-0.31950.630425.085839.797121.8537
206.0128-1.00181.9730.5358-0.18132.7588-0.46761.1086-0.1415-0.2921-0.70440.26840.448-0.0441-2.02080.3818-0.12170.52221.0124-0.53131.278437.524437.952119.0651
215.44541.97372.30374.2594-0.56255.65080.82930.2018-0.28690.86380.13460.3548-0.51-0.29261.71620.6671-0.31570.28961.1934-0.24091.001235.863245.058425.2209
220.88270.04470.19931.0305-0.24481.4698-0.03780.42030.00820.1846-0.1260.3147-0.2919-0.07650.79281.3847-0.3453-0.19220.8869-0.92141.31139.298145.365130.9414
237.067-1.1144.18038.17232.94745.9633-0.0627-0.11121.9184-0.7857-0.61710.8605-1.03670.44740.03220.5816-0.36560.15491.3936-0.07080.83640.949145.101716.7673
240.3154-0.75890.30391.6843-0.65370.5724-0.22340.9502-1.48210.6948-0.2255-0.3265-0.95540.77610.49460.7662-0.1890.14831.20370.07761.006545.448637.565822.7605
252.66931.4826-1.42159.7504-1.22242.8908-0.4904-0.41720.3953-0.34530.16122.402-0.7646-0.32840.24190.7604-0.1262-0.0490.8438-0.19410.782829.350447.664725.7959
261.97061.0483-0.40730.584-0.14390.2937-0.14190.4366-0.09880.02690.06810.1192-0.0283-0.0438-0.41530.0209-0.49470.44860.32-0.27821.314628.638140.969927.73
271.1592-0.43451.64710.5867-0.48752.3519-0.21230.1762-0.2723-0.30590.1045-0.91860.09060.8397-0.06390.1766-0.20370.05911.3047-0.03841.255845.515928.670228.0892
281.7066-0.42751.18371.7284-0.76782.7254-0.1859-1.20080.47050.3266-0.28050.5268-0.4439-1.71850.25190.44760.1269-0.09990.5124-0.31950.7146-26.374567.74871.0274
290.11660.0195-0.19210.6617-0.19241.3158-0.4942-0.4177-0.0682-0.05620.11410.5538-0.1529-1.1603-1.07320.44630.2695-0.22321.056-0.30240.8888-31.148469.195664.8898
303.4003-0.88432.97123.35241.07284.1577-0.4132-0.87740.06190.1530.37780.6626-0.3189-0.65890.0690.4880.067-0.06180.92350.09981.0354-50.949972.602241.0189
313.2561-0.5855-0.13560.7175-1.1122.4719-0.70580.4320.2276-1.00670.04610.0452-0.28530.46460.54680.4834-0.0468-0.04180.44090.17250.5474-19.326356.910747.0708
323.12850.2444-0.91270.794-1.88345.3569-0.0402-0.46870.927-0.8143-0.65940.1124-0.48840.8487-0.32140.4523-0.0085-0.05040.399-0.04320.5947-12.831157.474754.4037
330.52280.7722-0.7921.122-1.14192.24170.28020.6992-0.61420.1847-0.49690.59140.27640.02220.08430.4639-0.26440.05350.7808-0.21150.5903-24.350854.170459.315
341.86110.1115-0.10591.9672-1.12655.525-0.09710.0613-0.2166-0.1959-0.20.04620.57020.37160.28510.3550.14020.03140.4998-0.10810.6402-15.330148.403154.5472
350.88330.98410.46282.6685-3.2079.21220.69630.72521.18970.1033-0.61510.028-1.16971.73740.65650.49290.072-0.02030.7484-0.11480.696-16.640461.094660.0853
360.22770.4743-0.60973.1392-1.3711.99570.34470.91510.438-0.49050.7617-0.2417-0.0342-0.5432-0.46750.7805-0.05550.13390.75360.12470.864-30.629153.000740.252
372.8909-0.8766-0.31123.97631.53063.61310.68591.11661.0882-1.2759-0.72490.3144-0.67140.25240.13940.66730.0456-0.2230.95960.35940.8889-40.605372.093534.1776
382.3364-1.6454-0.5091.7987-0.0612.18270.1121.19320.68220.02780.36460.00790.2978-0.14090.07940.4867-0.0785-0.15760.79320.00871.0476-34.468768.35240.7275
392.5325-0.78591.82816.9261-1.71244.5994-0.91650.78470.786-1.1530.5016-0.39180.00991.27620.6770.51150.0043-0.0891.08560.0821.1146-35.463577.520635.5559
405.5828-1.08160.60843.00852.07381.80030.2490.33910.247-0.663-0.8704-0.6494-0.28631.0821-0.23550.289-0.10590.2270.8680.16721.2621-32.67370.559129.3505
410.8073-0.43160.13971.3233-0.03291.5562-0.3140.0037-0.0359-0.66260.13950.02030.17150.7076-0.05810.5617-0.0367-0.04990.7174-0.60810.646-6.840455.642473.3293
420.3310.6534-0.38791.58480.07742.82610.3234-0.25020.36740.24630.0352-0.3309-0.54461.02090.57530.96060.0056-0.60191.0407-0.561.398815.186966.805172.8188
433.5107-0.10371.05260.73080.51892.27780.03290.68810.78830.95170.42860.5608-0.30270.43330.03870.68360.34630.10070.6353-0.12250.79751.226951.700275.0531
442.0860.36430.88825.5653-1.67491.1897-0.12050.2026-1.15530.10411.4604-0.08440.67660.4969-0.09990.40990.2079-0.1141.1681-0.28140.75547.962650.775564.57
451.0378-0.1513-0.26550.4653-0.42360.5655-0.371.1181-0.6878-2.0153-1.2633-0.61590.13730.0167-0.19481.53860.47850.11380.77140.20071.170513.53843.998372.9403
460.88560.2637-0.97641.92340.17773.2409-0.1386-1.2822-0.35650.319-0.0149-0.54350.33241.73890.38970.51420.07170.04621.1180.00870.762210.376756.547976.6806
472.0372-1.74690.4011.54550.12129.01350.05420.0931-0.28210.70010.40031.011.4347-0.6080.35030.56280.3365-0.1170.6926-0.25950.7254-1.871247.945569.5829
484.3435-1.194-2.28663.7785-2.29613.6822-0.1065-0.64560.485-0.0123-0.2248-0.64830.17250.8528-0.54320.37480.388-0.31660.3789-0.11811.08065.477761.497367.497
493.48150.27510.76633.05331.31922.4045-0.14180.3485-0.1645-0.52250.1548-0.07010.0051.261-0.0510.8172-0.06070.05391.02870.090.503311.6112-7.210936.1929
501.75130.7226-0.64972.0915-0.40740.1536-0.41630.8451-0.497-0.30830.4718-0.2070.44070.92810.09230.5661-0.1890.08431.22130.00760.734717.3469-5.06141.0844
512.47721.6974-2.08392.2828-0.82463.667-0.02660.3570.26720.0794-0.10220.08810.5074-1.219-0.02040.4392-0.1564-0.0650.9850.06860.691733.539414.2957.2702
522.9254-0.2522-1.14713.8891-0.11921.8518-0.06531.2196-0.11920.02320.3359-0.56660.2605-0.1086-0.16710.3309-0.10310.03410.8660.06650.587636.88213.479456.0735
533.1257-0.21110.92432.41760.15762.6712-0.0642-0.18540.01410.08610.09360.1080.1420.1625-0.02040.5496-0.03310.05830.5360.03660.5630.248-9.719357.7385
543.0698-0.22910.86741.58042.13753.1115-0.07120.95470.12760.3259-0.01840.50910.13520.3260.23060.71340.00480.07020.95190.21660.58287.4099-6.994357.436
551.0731.5260.84663.9066-0.35092.3291-0.07410.10890.74230.29250.05330.6361-0.1049-1.02860.02770.5072-0.09870.03610.99940.17570.804319.997515.961360.7794
562.03460.39220.311.6068-1.29942.561-0.4010.7373-0.7908-0.62710.75481.29170.4939-0.9851-0.22531.1419-0.248-0.2021.3252-0.05051.0756-17.6651-16.161339.0709
572.18910.3697-1.02622.37341.31541.4477-0.8754-0.1655-2.4493-0.1830.3241-0.47210.8686-0.8487-0.61831.5417-0.26910.1771.05010.09491.1981-13.5239-26.053139.102
587.4414-0.88640.21332.7582-1.54525.9920.8205-0.2956-0.66410.84290.9481.28080.4822-0.123-0.21650.8221-0.13910.08180.9579-0.10311.1473-19.0495-22.055847.0588
596.56522.20671.31994.914-1.72974.59410.6111-0.5708-0.09331.2464-0.93890.8439-0.1705-0.5993-0.34771.018-0.54130.18432.19550.27831.0052-22.503-18.764851.8854
600.12430.006-0.10963.2222-2.53542.10180.1298-0.0536-1.07330.16050.3585-0.25771.18981.27490.15841.3658-0.3810.03591.5604-0.30161.0947-28.7795-27.708647.3673
610.85370.9067-0.07324.1009-1.19960.4069-0.03020.55320.272-0.92490.590.7990.91080.20030.62031.1113-0.1905-0.25231.3759-0.48280.9776-20.6495-27.517236.2943
622.78370.86180.58912.33960.57724.2816-0.54780.1206-0.63980.7533-0.00751.451.0012-1.1945-0.2590.6653-0.10740.03270.7858-0.14150.8617-24.6602-18.00942.4826
631.9062-0.7963-3.26231.04632.45657.2103-0.003-0.6802-0.7340.8371-0.0621-0.03070.88321.10760.14980.7648-0.1452-0.40510.47230.27531.3303-9.4155-23.514249.8344
640.82580.9122-0.94064.2547-1.55431.13980.30560.20631.29170.78880.06941.0749-0.4315-0.38430.90520.6699-0.15640.33150.1578-0.00541.4195-28.5392-7.07139.5794
652.8516-1.25531.78884.4591-1.37523.05890.0324-1.28740.05841.5812-0.0947-0.4894-0.79371.21280.16240.7017-00.01311.2538-0.06980.456-14.0275104.436359.8711
662.25410.27140.32423.26551.78813.2879-0.6034-0.33420.1126-0.5020.06260.5833-0.48810.616-0.00490.59340.1062-0.02820.63170.13520.6552-24.7986108.657857.0823
673.66480.72970.22134.09290.56893.32380.0855-0.74940.26950.1874-0.19940.8041.1114-1.0602-0.18610.7026-0.0571-0.14610.79180.18230.5902-24.600599.863660.4055
680.8759-0.92280.82734.9663-4.5624.31460.64660.1683-0.01520.302-0.6126-0.12160.10070.85960.05260.717-0.04940.04440.69530.10150.5152-18.426296.240157.4793
690.836-0.3075-1.43563.20961.74223.7199-0.3549-0.19120.77910.79940.3894-0.3888-0.08250.02270.10450.63660.10150.08730.5866-0.07060.7135-24.4222112.303150.9436
701.9098-1.8718-0.29631.76460.24870.0601-0.4548-1.4605-0.16610.21340.734-0.20480.05540.6876-0.34040.58810.19110.00721.316-0.0060.4781-5.99688.094557.4027
712.75060.1543-1.69552.570.10429.7262-0.28991.07880.4597-0.6004-0.2374-0.15350.4110.4602-0.34150.6506-0.09010.06710.87440.21380.5291-0.394475.867230.1235
722.3687-0.5811-1.07182.9882-0.06944.2587-0.430.27590.62780.293-0.1139-0.6157-0.4019-0.30260.67630.53930.03150.00411.11240.01020.68292.438483.435743.012
731.737-2.8359-0.09994.95561.51645.0489-0.3730.4942-0.1843-0.0673-0.6611-1.917-1.62461.14180.07670.8808-0.0879-0.22571.0090.22890.9817.527886.883935.9721
742.40460.07760.38922.74-0.11684.87350.2346-0.35580.2093-0.08640.2751-0.2663-0.02270.47030.1810.52410.0494-0.05420.6525-0.00760.56531.84781.826438.5741
751.9798-0.6622-0.37971.31611.32957.1026-0.328-0.2694-0.38740.5381-0.33960.20631.09250.6427-0.01040.3886-0.0891-0.01970.99960.15410.978.572575.745643.1558
762.5072-0.18410.2163.57610.70861.46080.1975-0.33270.0537-0.0119-0.40810.2214-0.1579-0.13010.16840.53020.0542-0.09370.85390.0740.6654-31.9345104.642537.6869
773.68910.4309-1.78511.80161.79832.90750.3849-0.1406-0.2955-0.0838-0.23920.2389-0.1842-0.68050.26260.51690.1397-0.03930.82950.18970.5198-24.7767101.865137.9565
782.14140.0902-0.31432.2276-0.01495.5753-0.23010.5011-0.5506-1.0405-0.4162-0.70590.67850.14760.33760.4659-0.1698-0.00140.76970.20940.7098-6.872577.217632.7989
792.4481-0.53170.84532.1239-0.25422.42250.0527-0.0976-0.6590.20150.04710.3399-0.1645-0.8395-0.02440.49460.02610.03460.84630.12230.6402-13.474578.981134.5754
801.81390.2843-0.12140.88820.19071.70710.1944-0.84370.82820.0838-0.06190.339-0.2876-0.61410.15460.90190.41080.04441.92410.15670.7987-48.9311115.224554.6565
813.19751.1803-1.12032.1298-2.0752.0198-0.53-0.1517-0.2726-1.4807-0.71360.4325-0.2242-1.17060.07030.97590.1482-0.13942.14780.13420.9619-54.7966113.716643.8298
821.58071.18761.72211.08490.7653.22510.34140.6699-0.4526-0.97610.2237-0.07690.31271.0241-0.86131.35020.42290.30170.9137-0.55451.6388-60.627122.348248.8665
831.093-0.83230.57786.0292-2.04630.79510.5921.17620.6476-0.70380.14440.6702-0.1117-0.22860.14650.90420.6061-0.0112.0862-0.23411.0931-53.0767120.551659.1044
840.494-0.55480.1431.20660.71711.57910.06820.1538-0.9436-0.1072-0.44780.8104-0.7604-1.3589-0.28480.91110.5077-0.18241.669-0.25751.268-58.038110.798951.1268
850.0029-0.0104-0.01130.09730.06820.0460.1841-0.21620.5514-0.12520.750.4576-1.14420.07160.22431.66070.65320.12861.6451-0.14910.7815-38.4867125.555242.2296
861.092-0.82940.30540.8221-0.57860.63450.39370.16590.0028-0.14310.08751.14570.1096-0.89790.08240.68070.16680.06250.85030.03231.2003-52.724106.74852.6471
873.2629-0.4023-0.551.1059-0.96653.13020.060.6468-0.1106-0.26440.3025-0.162-0.48280.3862-0.31270.8106-0.1164-0.02890.7376-0.15740.5123-5.566377.696482.2089
881.63641.0064-0.36851.29470.42052.428-0.20590.1941-0.289-0.67320.6508-0.308-0.4832-0.586-0.18771.2727-0.05690.16640.7639-0.01090.5085-5.231679.956479.4518
891.49820.0002-0.19531.2926-0.52910.2189-0.22930.13220.42850.72260.3891-0.3804-0.73510.3176-0.22470.9994-0.2476-0.00010.8941-0.04780.6626-0.39483.278184.8443
900.67010.3299-0.11531.6235-0.7760.36520.2809-0.103-0.16330.89090.1678-0.15420.72880.05720.27281.5711-0.10880.15050.4062-0.42630.9017.1678114.7163102.5146
911.3732-0.2462-1.15493.2113-2.06533.0348-0.00640.17110.7214-0.45550.0225-0.45340.63071.07190.09110.8434-0.24820.06590.7609-0.26850.82789.7148104.366190.6163
921.02150.13620.12650.78470.1260.7084-0.0243-0.5110.39820.3107-0.2744-0.4953-0.46731.96770.17531.2141-0.36190.14191.1449-0.25220.712916.2431112.565100.0994
932.1183-0.26471.03510.6202-1.10562.2149-1.0534-0.04410.7018-0.70990.2588-0.0766-0.89141.54490.36770.9816-0.24450.14561.42-0.04441.154314.4365115.253288.2481
942.33781.451-0.73932.04280.39661.75670.16390.48621.26580.4078-0.71220.6070.01680.61910.43120.92720.1697-0.00390.6913-0.06530.6169-11.45684.2228107.0519
950.38810.0511-0.32891.69821.93543.2367-0.4564-0.0729-0.3496-0.05470.35590.1239-0.09510.89030.08630.6937-0.10590.09150.7053-0.14650.6815-13.362674.674101.3952
963.136-0.24091.19811.7394-0.10027.5078-0.15750.1744-1.15150.3029-0.1883-0.3320.7578-0.68450.58060.9278-0.04070.13270.1564-0.20340.7775-8.874670.3348107.9715
970.64870.67930.28553.3262-0.40871.1972-0.6454-0.0823-0.3589-0.56780.3478-0.2616-0.77880.64770.27930.7082-0.13050.06260.5026-0.13460.5872-10.724977.7496106.4787
982.22711.340.11884.13332.64822.0121-0.13120.5918-0.2043-0.30230.22680.2919-0.8375-0.34080.91670.78970.05710.09970.4488-0.09360.7242-8.803582.5437101.1494
993.16520.5417-1.65830.1317-0.42531.55280.39831.01870.74030.3212-0.0910.5335-0.559-0.5023-0.13981.10840.1217-0.0150.6086-0.18640.7491-3.0197107.385799.9588
1002.4244-0.05241.82342.04850.31821.89590.1117-0.01490.8360.1199-0.1855-0.7911-0.7360.8355-0.4011.0505-0.00660.18220.9729-0.23140.49641.3216106.211598.4806
1012.31670.7821-0.32931.41041.33352.2920.83420.42930.28450.0288-0.4157-0.2855-0.1403-0.5261.61251.13020.23720.17450.5911-0.14921.0529-9.0236108.349105.3399
1020.8445-0.48051.29672.7927-1.81322.4127-0.3045-0.96-0.6609-0.21030.11480.49940.6625-0.1453-0.02840.46610.0319-0.14621.2038-0.17820.7539-18.194660.705391.2963
1031.6022-0.08011.13951.16420.22480.8777-0.2066-0.13230.48290.144-0.19591.50170.1445-1.1145-0.06060.289-0.330.03081.7325-0.4160.9215-42.634559.818487.7496
1045.37074.8382-2.52115.7238-0.02344.8499-0.656-0.3624-0.85450.4422-0.7277-1.05760.7886-0.1619-4.3811.2752-0.180.17140.2791-0.24920.0571-21.148152.656890.6839
1056.7483-0.0272-1.17691.31890.64246.53470.7392-0.50661.14160.6910.7158-0.3275-0.4031-0.55170.87741.0381-0.30720.41220.8324-0.1640.9112-27.094855.712598.5432
1067.07275.56783.37016.5298-1.53049.7434-0.0535-1.40780.58830.5797-0.0351.42160.3974-2.14310.44051.0864-0.455-0.09431.78680.23270.8664-30.98758.0989103.3204
1072.755-2.7122-1.91472.83711.24883.8474-0.1381-0.91610.49722.60760.17670.59070.58760.13210.20492.2962-0.23960.00210.5306-0.37931.5668-32.754146.3767103.0297
1081.09850.6-0.69350.868-1.31712.4158-1.142-0.6448-0.19341.04570.6142-0.21110.97220.05190.81591.1184-0.14180.28250.8426-0.23370.7699-28.27649.838689.1316
1092.73311.7126-1.53132.9640.61512.1947-0.54220.7859-0.431-0.39010.41310.50250.7742-0.62740.1160.5976-0.62340.22461.2117-0.19071.5792-44.559557.947995.5481
1108.97870.6647-2.16028.7142-1.84894.9006-0.9169-0.3359-0.5364-0.2675-1.11970.78730.6181-0.5067-5.52561.1972-0.16570.04481.1634-0.39240.4734-26.294859.035297.0487
1110.5267-0.2621-0.48470.13250.24250.44380.26470.2178-0.11370.88660.3838-1.30751.31080.58550.03941.3164-0.0655-0.4110.5521-0.16021.1422-11.939153.2339104.3353
1121.7622-3.1371-0.69665.87170.78083.1697-0.4252-0.42210.40051.18040.39330.35010.28180.0224-0.20010.5623-0.28620.07791.0702-0.19490.8862-22.048262.698996.6439
1133.00792.2493-0.07683.25121.77362.1209-0.03570.5377-0.07490.3382-0.10271.67550.0049-0.5194-0.16780.4546-0.28790.0021.09090.45221.2074-42.017764.905590.6171
1140.8625-0.29450.38252.3524-0.15280.1493-0.4134-0.36110.40990.60670.5872-0.01290.1375-0.3643-0.24340.73210.02630.13350.6653-0.27870.708631.12620.154713.4234
1152.62360.5227-0.08592.4307-0.48183.95520.1218-1.03060.41610.42740.08790.53450.62260.4201-0.21710.8768-0.09370.07210.8479-0.08210.556522.740317.045614.8191
1161.9208-0.1776-0.18171.3086-0.8564.92650.1487-0.6431-0.02030.3175-0.3030.7142-0.16470.3149-0.18560.76130.1055-0.03911.0785-0.20790.521427.433711.010913.6272
1170.7985-0.8002-0.79882.6308-0.29081.39020.18870.10470.00210.0187-0.19430.8359-0.0394-0.893-0.08420.60920.0140.04880.4506-0.26510.747428.319826.45513.6794
1182.8202-0.45680.61541.4793-1.09780.8266-0.18220.8134-0.1093-0.33990.3708-0.4961.14010.577-0.07550.92380.18330.15620.5427-0.27270.837135.9516-0.703916.9212
1190.287-0.31950.05630.4802-0.10230.02050.42130.0764-0.467-0.04091.4573-0.3961-0.85230.6133-0.17711.007-0.0835-0.06991.1321-0.26660.989339.5788-19.6668-6.7101
1201.6169-0.15290.82411.58930.24595.5142-0.2710.5667-0.07190.08650.0733-0.71480.04081.53290.4181.2280.2917-0.10990.752-0.19341.093843.631-10.92385.1435
1210.1841-0.39360.02460.8217-0.04390.2765-0.1606-0.5285-0.08241.3729-1.1804-0.78531.5030.44760.53411.37240.31940.13661.29490.17761.195550.332-10.9489-1.3063
1221.8263-0.07750.39620.00110.00371.61410.8868-0.45410.10970.3958-0.58780.02560.3976-0.16481.70791.49150.0931-0.30270.7547-0.46040.749431.333-3.550511.5306
1230.2407-0.3594-0.11370.52810.09080.28570.03920.3277-0.5348-0.92180.1996-0.71190.29220.1525-0.64391.8580.5335-0.00070.3172-0.82760.828748.6568-17.8419-4.2406
1240.1402-0.28170.20610.4356-0.31730.2254-0.35890.27220.423-0.3538-0.3506-0.57010.37261.1661-0.08341.27320.3009-0.01251.0565-0.12941.072346.4678-20.17827.6397
1252.0431-0.84040.81512.67430.24780.60990.5756-0.7687-0.85030.4235-0.76450.09480.21760.6329-0.22371.219-0.0354-0.14440.7998-0.17930.536621.230710.7709-11.1939
1260.8335-0.12751.55312.1752-0.26215.0162-0.2541-0.230.31610.0089-0.00290.15030.1701-0.59990.27540.5561-0.04020.03060.5531-0.19160.546421.007720.8619-9.5844
1272.7726-2.7955-2.08833.22540.91854.5352-0.2972-0.6355-0.23850.3951-0.18821.2181.0218-0.21630.42170.54610.03110.06971.2391-0.27850.740219.116418.46890.2728
1283.1854-0.18780.2312.5165-0.16471.6822-0.18180.1732-0.6549-0.92530.3760.31581.4892-0.7096-0.26071.3309-0.3408-0.11960.7907-0.11390.708829.6085-9.9091-6.689
1295.2964-2.2538-1.85541.10670.2312.9317-0.25190.5169-1.0939-0.13240.1049-0.0436-1.1663-0.7981-0.0820.5833-0.06050.14940.8281-0.04090.690314.336334.65533.7991
1304.41583.36513.26632.89632.01293.2180.3046-0.76590.0910.2321-2.04752.18730.0374-2.05381.13830.85390.0060.11281.8408-0.19211.2264-10.111434.83487.342
1310.72791.0977-0.29761.7081-0.72941.879-0.04650.0860.31950.0493-0.44570.35410.3249-0.5046-0.62570.82760.4138-0.51691.1128-0.61720.97782.264638.7056.6946
1320.96120.30260.18181.74530.63040.2623-0.03480.155-0.2557-0.3617-1.11580.0174-0.56241.1155-0.11730.57740.1604-0.08441.18310.02440.819218.244445.74122.6473
1334.33520.469-3.35510.62380.24163.2560.8142-0.1798-0.4655-0.09150.6749-0.3258-0.25750.46440.51321.00210.2728-0.44191.2929-0.2270.8425.342339.4542-3.5648
1346.0516-1.0881-2.43543.8643-2.96094.14170.44211.8944-0.1796-1.4909-0.6141-0.22180.7747-0.1767-0.37951.00710.3147-0.04251.9418-0.05970.86741.804637.099-8.5621
1350.3207-0.7174-0.3862.10290.4190.88550.39860.07160.0941-0.3953-0.04860.33790.09240.19411.55520.69450.5108-0.06960.4798-0.54741.5265-1.254546.7481-0.91
1362.5535-0.9228-1.26071.4944-1.05892.5949-2.2756-0.71571.6661-1.75550.314-0.0036-0.13570.97120.62351.01740.0605-0.13990.9097-0.14680.88095.646844.59737.8638
1370.9585-0.77390.50290.7015-0.32450.3449-1.28930.18610.5482-0.39160.63080.1181-0.6757-0.10710.46361.32780.0276-0.20070.9519-0.26621.003-12.01836.684-0.1963
1382.39920.40030.94453.4781-1.63094.1654-1.21490.10510.1722-0.2834-0.39980.1562-0.3519-0.2298-3.06011.24520.295-0.23211.404-0.54170.6516.223336.1862-2.1215
1390.4805-0.9182-0.17532.94991.22870.7298-0.7739-0.021-1.0589-0.706-0.33061.2853-0.3836-0.5540.17840.98420.17630.28711.4651-0.09371.163520.361642.3803-9.3816
1401.97470.27831.7973.7376-0.0572.8754-0.7916-0.01860.26750.55220.23210.1174-0.20630.8995-0.13690.27960.1065-0.10531.0818-0.24760.74610.477132.7072-1.6741
1410.5417-0.9144-0.27151.60750.10291.9523-0.7418-0.2996-0.4495-0.53240.79441.24820.384-0.41350.34920.6481-0.1631-0.06581.3611-0.1641.2329-9.374529.84944.5058
1422.6439-2.5460.09152.7381-0.58840.73620.03490.2475-0.0505-0.2246-0.11210.3978-0.1762-0.22920.02970.8571-0.1254-0.10390.8039-0.2210.581-10.0355-6.078421.7759
1430.55520.19350.03422.40780.19941.3199-0.20160.230.0284-0.50690.09670.2278-0.0507-0.4133-0.00490.93570.1092-0.14251.2301-0.12620.6953-23.85449.6413-3.098
1441.41120.4046-0.55941.90140.96042.1470.06851.0529-0.622-0.2639-0.0604-0.15610.46370.51720.04081.14560.1499-0.14451.544-0.46360.8136-2.0962-21.0824.1853
1451.5081-0.28271.33030.4416-1.43764.35210.05860.9112-0.4554-0.3892-0.50290.04740.42150.95690.11181.05950.1003-0.04911.4309-0.40540.7645-7.6958-16.0332.7328
1462.79850.27151.17061.30511.63952.20590.57850.05030.2899-0.6139-0.38580.2714-0.25010.5384-0.27341.0786-0.19320.0011.5758-0.27750.7627-11.25365.8378-10.8949
1475.924-2.16674.27840.9752-2.28876.0289-0.99830.78030.02060.93330.3036-0.37720.90891.4305-0.65471.061-0.1060.04620.9399-0.54090.70363.0182-26.086823.7939
1482.28531.0281.08942.2509-1.08312.104-0.10670.8143-0.14370.5245-0.1414-0.20230.31480.60910.04511.13280.58360.10550.766-0.34281.022813.8192-30.851325.7332
1494.9335-1.21391.82634.92980.55046.07480.70110.38060.7930.23780.3277-0.22620.15120.4248-0.46910.8550.2388-0.06281.0347-0.49591.490515.9106-34.930715.362
1500.0168-0.0158-0.01360.01080.01570.02760.4496-0.1550.30440.4552-0.6186-0.94110.2287-0.498-0.18511.4837-0.0076-0.29192.1837-0.0161.684514.7164-46.310822.7445
1515.28380.981-4.38950.9837-1.37784.17890.41760.0795-1.01960.6686-0.6246-0.5281.2044-0.29820.43141.36460.1975-0.07291.4942-0.20140.918619.8849-38.423826.5295
1520.1583-0.28020.36360.5023-0.65240.8550.2846-1.21560.5287-0.48481.0892-0.00090.0654-0.3317-0.58271.21540.33630.4081.6503-0.09031.150311.4495-32.039532.9909
1533.70960.3707-0.81411.60041.24911.3103-1.0285-0.9656-1.52490.24821.0187-1.4530.27221.0316-0.1751.44910.5835-0.07282.18640.14641.329429.3471-30.513821.8752
1547.49735.0004-0.73448.45470.39691.11060.94050.41810.67650.8144-1.13631.17591.24630.78660.5821.3762-0.0775-0.08641.3090.04190.654511.1469-30.792420.0558
1553.448-2.62580.69872.024-0.60273.02160.43770.6258-2.08210.194-0.3769-0.02850.5122-0.7355-0.78180.58030.4612-0.3631.0847-0.11591.085311.4229-28.917319.3446
1562.40271.00670.62172.955-1.52461.5804-0.06860.98720.0803-0.6456-0.71170.46920.1912-0.43210.27380.7598-0.02590.15071.4478-0.09760.6404-46.1731103.510972.6424
1570.95840.7035-0.62881.9983-0.23842.13410.1390.54070.0295-0.4062-0.0786-0.14770.0962-0.45930.34720.7703-0.01080.03851.6487-0.13320.6146-37.803599.979773.068
1583.10521.8042-0.32485.0839-0.87171.80430.1742-1.7332-0.5848-1.0411-0.6327-0.66880.4851-0.46050.350.7890.14130.07881.4241-0.02450.6352-42.505195.867277.7125
1590.3989-0.8182-0.172.576-1.50974.07550.4840.04290.12791.0965-0.2807-0.032-0.3081-0.73650.31580.6907-0.1043-0.03471.4905-0.08390.7916-42.9942114.312876.8881
1601.10681.4779-0.40014.20750.08580.2913-0.8705-0.3552-0.0543-0.60980.10751.10060.7699-0.97660.20760.88390.09770.18321.4393-0.24230.8619-51.020484.485282.0653
1612.8071.10162.82532.73271.39122.89780.9957-0.4752-0.68411.5497-0.41590.0151-0.026-0.0716-0.40441.178-0.05210.11651.34840.06540.6953-53.981982.7819112.3859
1620.7266-0.77390.08011.39041.1182.68850.18750.7782-0.50450.18030.11160.543-0.275-0.97230.00320.9384-0.27360.30031.8713-0.29690.7004-58.411383.032197.7517
1638.0475-2.0042-1.59082.8223-0.29661.11850.4645-0.1429-0.26951.07370.77750.4961-0.2997-0.72811.19331.34520.42240.32111.5022-0.24950.6064-64.992586.8737103.1226
1642.6168-0.45131.45322.6448-1.41061.28540.01170.27890.38330.24320.37650.19550.9415-0.355-0.42521.0961-0.14840.10081.149-0.2410.6744-57.655883.5611102.349
1652.0249-0.2235-0.29271.9016-0.00871.9053-0.25512.126-0.6895-0.96120.62470.17890.9411-1.8031-0.05750.8656-0.19310.26081.46050.24310.8976-61.473174.0249101.2493
1661.4240.2181-0.25082.0904-1.59112.2805-0.1891-0.91130.52740.36670.22650.1059-0.49950.45470.20650.8073-0.13250.01911.2365-0.31590.7892-34.2655115.248491.0458
1672.05420.7803-1.07670.6045-1.27272.098-0.1038-0.39520.26520.12890.0392-0.0978-0.2482-0.2737-0.00410.730.0137-0.06021.4499-0.15720.6798-40.1532107.448795.7769
1682.99050.69540.74050.4876-0.25913.0701-0.0277-0.0186-0.9922-0.00580.02240.09290.2849-0.09160.21030.87950.0390.1381.306-0.27040.8577-45.704389.6659103.7378
1694.94211.9506-0.62456.24350.20654.51380.77420.9215-0.463-0.5483-0.9759-1.48941.33130.5609-0.02141.44440.13-0.19131.6409-0.43241.104-39.072785.5033110.225
1702.25661.0891-1.67671.1116-0.49263.3822-0.25390.1587-0.1377-0.36110.0006-0.2659-0.72750.21760.11810.73170.04290.13261.0989-0.22020.7794-28.9391120.51871.7869
1710.3509-0.05480.64051.9666-2.30783.64040.30350.2359-0.6474-0.0459-0.50450.5428-1.21221.22810.20961.2156-0.23750.15990.6697-0.10431.2902-4.557118.820268.3775
1720.88580.486-0.20180.5323-0.02922.15570.167-0.69661.01791.0106-0.14040.6663-0.3038-0.24160.18061.3324-0.29890.0850.9089-0.30571.1813-23.2432127.562470.3686
1734.6491.3709-2.80972.3370.94443.36460.7051-1.34370.041-0.149-0.6498-1.2479-0.17861.02380.52251.2233-0.4450.17661.7767-0.17491.5174-15.8989129.129980.2272
1740.1872-0.11950.49080.0732-0.3211.3541-0.03530.17410.92470.6328-0.2479-1.6568-1.0116-0.3675-0.16361.5313-0.43260.09761.84220.03571.8233-14.2078139.082973.0787
1752.4986-2.96161.48216.2215-2.99951.9488-0.60480.23821.83510.6808-0.7174-0.1123-0.9147-0.98020.540.939-0.1621-0.06711.08070.10470.9497-18.7339128.077863.759
1760.0708-0.0655-0.02220.09310.0620.073-1.3370.71571.24021.3020.8054-1.37210.42631.76971.08711.4939-0.1818-0.12961.31140.21961.4039-2.4944124.712773.6379
1773.6989-1.844-0.41034.3924-0.93451.51410.2323-0.18940.180.3629-0.65820.7393-0.6197-0.2218-0.32261.36620.40930.02120.7585-0.30170.2224-20.8023125.042775.5574
178-0.00030.0043-0.00290.1429-0.15790.16990.99260.74510.2066-0.00590.35540.1477-1.3318-1.1855-0.54082.54280.5199-0.42691.4406-0.47331.8946-35.3686133.917578.4338
1790.4541-0.03690.78970.88060.34531.5702-0.39350.05170.808-0.2661-0.726-0.4466-1.35590.13150.25390.7372-0.2075-0.07010.6769-0.01170.8775-25.0793121.881677.3434
1802.8306-2.08561.65412.80050.09212.34420.0368-0.305-0.8352-0.8957-0.1414-1.55760.9165-0.1019-0.15891.0888-0.0170.04610.87710.20181.2662-5.1387116.30573.6634
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection details
1X-RAY DIFFRACTION1chain 'C' and (resid 1 through 25 )
2X-RAY DIFFRACTION2chain 'C' and (resid 26 through 90 )
3X-RAY DIFFRACTION3chain 'C' and (resid 91 through 101 )
4X-RAY DIFFRACTION4chain 'C' and (resid 102 through 113 )
5X-RAY DIFFRACTION5chain 'C' and (resid 114 through 128 )
6X-RAY DIFFRACTION6chain 'C' and (resid 129 through 163 )
7X-RAY DIFFRACTION7chain 'C' and (resid 164 through 174 )
8X-RAY DIFFRACTION8chain 'C' and (resid 175 through 197 )
9X-RAY DIFFRACTION9chain 'C' and (resid 198 through 213 )
10X-RAY DIFFRACTION10chain 'B' and (resid 1 through 16 )
11X-RAY DIFFRACTION11chain 'B' and (resid 17 through 39 )
12X-RAY DIFFRACTION12chain 'B' and (resid 40 through 67 )
13X-RAY DIFFRACTION13chain 'B' and (resid 68 through 91 )
14X-RAY DIFFRACTION14chain 'B' and (resid 92 through 111 )
15X-RAY DIFFRACTION15chain 'B' and (resid 112 through 150 )
16X-RAY DIFFRACTION16chain 'B' and (resid 151 through 170 )
17X-RAY DIFFRACTION17chain 'B' and (resid 171 through 180 )
18X-RAY DIFFRACTION18chain 'B' and (resid 181 through 220 )
19X-RAY DIFFRACTION19chain 'A' and (resid 30 through 40 )
20X-RAY DIFFRACTION20chain 'A' and (resid 41 through 62 )
21X-RAY DIFFRACTION21chain 'A' and (resid 63 through 70 )
22X-RAY DIFFRACTION22chain 'A' and (resid 71 through 82 )
23X-RAY DIFFRACTION23chain 'A' and (resid 83 through 104 )
24X-RAY DIFFRACTION24chain 'A' and (resid 105 through 118 )
25X-RAY DIFFRACTION25chain 'A' and (resid 119 through 133 )
26X-RAY DIFFRACTION26chain 'A' and (resid 134 through 139 )
27X-RAY DIFFRACTION27chain 'A' and (resid 140 through 146 )
28X-RAY DIFFRACTION28chain 'D' and (resid 1 through 75 )
29X-RAY DIFFRACTION29chain 'D' and (resid 76 through 113 )
30X-RAY DIFFRACTION30chain 'D' and (resid 114 through 213 )
31X-RAY DIFFRACTION31chain 'E' and (resid 1 through 16 )
32X-RAY DIFFRACTION32chain 'E' and (resid 17 through 39 )
33X-RAY DIFFRACTION33chain 'E' and (resid 40 through 51 )
34X-RAY DIFFRACTION34chain 'E' and (resid 52 through 91 )
35X-RAY DIFFRACTION35chain 'E' and (resid 92 through 111 )
36X-RAY DIFFRACTION36chain 'E' and (resid 112 through 124 )
37X-RAY DIFFRACTION37chain 'E' and (resid 125 through 150 )
38X-RAY DIFFRACTION38chain 'E' and (resid 151 through 180 )
39X-RAY DIFFRACTION39chain 'E' and (resid 181 through 205 )
40X-RAY DIFFRACTION40chain 'E' and (resid 206 through 220 )
41X-RAY DIFFRACTION41chain 'F' and (resid 30 through 40 )
42X-RAY DIFFRACTION42chain 'F' and (resid 41 through 49 )
43X-RAY DIFFRACTION43chain 'F' and (resid 50 through 70 )
44X-RAY DIFFRACTION44chain 'F' and (resid 71 through 82 )
45X-RAY DIFFRACTION45chain 'F' and (resid 83 through 94 )
46X-RAY DIFFRACTION46chain 'F' and (resid 95 through 118 )
47X-RAY DIFFRACTION47chain 'F' and (resid 119 through 133 )
48X-RAY DIFFRACTION48chain 'F' and (resid 134 through 146 )
49X-RAY DIFFRACTION49chain 'G' and (resid 1 through 90 )
50X-RAY DIFFRACTION50chain 'G' and (resid 91 through 113 )
51X-RAY DIFFRACTION51chain 'G' and (resid 114 through 150 )
52X-RAY DIFFRACTION52chain 'G' and (resid 151 through 213 )
53X-RAY DIFFRACTION53chain 'H' and (resid 1 through 83 )
54X-RAY DIFFRACTION54chain 'H' and (resid 84 through 124 )
55X-RAY DIFFRACTION55chain 'H' and (resid 125 through 216 )
56X-RAY DIFFRACTION56chain 'I' and (resid 30 through 49 )
57X-RAY DIFFRACTION57chain 'I' and (resid 50 through 62 )
58X-RAY DIFFRACTION58chain 'I' and (resid 63 through 70 )
59X-RAY DIFFRACTION59chain 'I' and (resid 71 through 82 )
60X-RAY DIFFRACTION60chain 'I' and (resid 83 through 94 )
61X-RAY DIFFRACTION61chain 'I' and (resid 95 through 104 )
62X-RAY DIFFRACTION62chain 'I' and (resid 105 through 127 )
63X-RAY DIFFRACTION63chain 'I' and (resid 128 through 139 )
64X-RAY DIFFRACTION64chain 'I' and (resid 140 through 146 )
65X-RAY DIFFRACTION65chain 'J' and (resid 1 through 25 )
66X-RAY DIFFRACTION66chain 'J' and (resid 26 through 38 )
67X-RAY DIFFRACTION67chain 'J' and (resid 39 through 75 )
68X-RAY DIFFRACTION68chain 'J' and (resid 76 through 90 )
69X-RAY DIFFRACTION69chain 'J' and (resid 91 through 101 )
70X-RAY DIFFRACTION70chain 'J' and (resid 102 through 113 )
71X-RAY DIFFRACTION71chain 'J' and (resid 114 through 128 )
72X-RAY DIFFRACTION72chain 'J' and (resid 129 through 150 )
73X-RAY DIFFRACTION73chain 'J' and (resid 151 through 163 )
74X-RAY DIFFRACTION74chain 'J' and (resid 164 through 197 )
75X-RAY DIFFRACTION75chain 'J' and (resid 198 through 213 )
76X-RAY DIFFRACTION76chain 'K' and (resid 1 through 83 )
77X-RAY DIFFRACTION77chain 'K' and (resid 84 through 124 )
78X-RAY DIFFRACTION78chain 'K' and (resid 125 through 150 )
79X-RAY DIFFRACTION79chain 'K' and (resid 151 through 218 )
80X-RAY DIFFRACTION80chain 'L' and (resid 30 through 70 )
81X-RAY DIFFRACTION81chain 'L' and (resid 71 through 82 )
82X-RAY DIFFRACTION82chain 'L' and (resid 83 through 94 )
83X-RAY DIFFRACTION83chain 'L' and (resid 95 through 110 )
84X-RAY DIFFRACTION84chain 'L' and (resid 111 through 127 )
85X-RAY DIFFRACTION85chain 'L' and (resid 128 through 133 )
86X-RAY DIFFRACTION86chain 'L' and (resid 134 through 146 )
87X-RAY DIFFRACTION87chain 'M' and (resid 1 through 61 )
88X-RAY DIFFRACTION88chain 'M' and (resid 62 through 90 )
89X-RAY DIFFRACTION89chain 'M' and (resid 91 through 113 )
90X-RAY DIFFRACTION90chain 'M' and (resid 114 through 128 )
91X-RAY DIFFRACTION91chain 'M' and (resid 129 through 174 )
92X-RAY DIFFRACTION92chain 'M' and (resid 175 through 197 )
93X-RAY DIFFRACTION93chain 'M' and (resid 198 through 213 )
94X-RAY DIFFRACTION94chain 'N' and (resid 1 through 17 )
95X-RAY DIFFRACTION95chain 'N' and (resid 18 through 60 )
96X-RAY DIFFRACTION96chain 'N' and (resid 61 through 73 )
97X-RAY DIFFRACTION97chain 'N' and (resid 74 through 99 )
98X-RAY DIFFRACTION98chain 'N' and (resid 100 through 124 )
99X-RAY DIFFRACTION99chain 'N' and (resid 125 through 170 )
100X-RAY DIFFRACTION100chain 'N' and (resid 171 through 195 )
101X-RAY DIFFRACTION101chain 'N' and (resid 196 through 215 )
102X-RAY DIFFRACTION102chain 'O' and (resid 30 through 40 )
103X-RAY DIFFRACTION103chain 'O' and (resid 41 through 49 )
104X-RAY DIFFRACTION104chain 'O' and (resid 50 through 62 )
105X-RAY DIFFRACTION105chain 'O' and (resid 63 through 70 )
106X-RAY DIFFRACTION106chain 'O' and (resid 71 through 82 )
107X-RAY DIFFRACTION107chain 'O' and (resid 83 through 94 )
108X-RAY DIFFRACTION108chain 'O' and (resid 95 through 110 )
109X-RAY DIFFRACTION109chain 'O' and (resid 111 through 118 )
110X-RAY DIFFRACTION110chain 'O' and (resid 119 through 127 )
111X-RAY DIFFRACTION111chain 'O' and (resid 128 through 133 )
112X-RAY DIFFRACTION112chain 'O' and (resid 134 through 139 )
113X-RAY DIFFRACTION113chain 'O' and (resid 140 through 146 )
114X-RAY DIFFRACTION114chain 'P' and (resid 1 through 38 )
115X-RAY DIFFRACTION115chain 'P' and (resid 39 through 75 )
116X-RAY DIFFRACTION116chain 'P' and (resid 76 through 90 )
117X-RAY DIFFRACTION117chain 'P' and (resid 91 through 101 )
118X-RAY DIFFRACTION118chain 'P' and (resid 102 through 113 )
119X-RAY DIFFRACTION119chain 'P' and (resid 114 through 128 )
120X-RAY DIFFRACTION120chain 'P' and (resid 129 through 150 )
121X-RAY DIFFRACTION121chain 'P' and (resid 151 through 163 )
122X-RAY DIFFRACTION122chain 'P' and (resid 164 through 174 )
123X-RAY DIFFRACTION123chain 'P' and (resid 175 through 197 )
124X-RAY DIFFRACTION124chain 'P' and (resid 198 through 213 )
125X-RAY DIFFRACTION125chain 'Q' and (resid 1 through 16 )
126X-RAY DIFFRACTION126chain 'Q' and (resid 17 through 91 )
127X-RAY DIFFRACTION127chain 'Q' and (resid 92 through 111 )
128X-RAY DIFFRACTION128chain 'Q' and (resid 112 through 216 )
129X-RAY DIFFRACTION129chain 'R' and (resid 30 through 40 )
130X-RAY DIFFRACTION130chain 'R' and (resid 41 through 49 )
131X-RAY DIFFRACTION131chain 'R' and (resid 50 through 55 )
132X-RAY DIFFRACTION132chain 'R' and (resid 56 through 62 )
133X-RAY DIFFRACTION133chain 'R' and (resid 63 through 70 )
134X-RAY DIFFRACTION134chain 'R' and (resid 71 through 82 )
135X-RAY DIFFRACTION135chain 'R' and (resid 83 through 99 )
136X-RAY DIFFRACTION136chain 'R' and (resid 100 through 110 )
137X-RAY DIFFRACTION137chain 'R' and (resid 111 through 118 )
138X-RAY DIFFRACTION138chain 'R' and (resid 119 through 127 )
139X-RAY DIFFRACTION139chain 'R' and (resid 128 through 133 )
140X-RAY DIFFRACTION140chain 'R' and (resid 134 through 139 )
141X-RAY DIFFRACTION141chain 'R' and (resid 140 through 146 )
142X-RAY DIFFRACTION142chain 'V' and (resid 1 through 90 )
143X-RAY DIFFRACTION143chain 'V' and (resid 91 through 213 )
144X-RAY DIFFRACTION144chain 'W' and (resid 1 through 83 )
145X-RAY DIFFRACTION145chain 'W' and (resid 84 through 124 )
146X-RAY DIFFRACTION146chain 'W' and (resid 125 through 217 )
147X-RAY DIFFRACTION147chain 'X' and (resid 30 through 40 )
148X-RAY DIFFRACTION148chain 'X' and (resid 41 through 70 )
149X-RAY DIFFRACTION149chain 'X' and (resid 71 through 82 )
150X-RAY DIFFRACTION150chain 'X' and (resid 83 through 90 )
151X-RAY DIFFRACTION151chain 'X' and (resid 91 through 99 )
152X-RAY DIFFRACTION152chain 'X' and (resid 100 through 110 )
153X-RAY DIFFRACTION153chain 'X' and (resid 111 through 118 )
154X-RAY DIFFRACTION154chain 'X' and (resid 119 through 127 )
155X-RAY DIFFRACTION155chain 'X' and (resid 128 through 146 )
156X-RAY DIFFRACTION156chain 'S' and (resid 1 through 38 )
157X-RAY DIFFRACTION157chain 'S' and (resid 39 through 75 )
158X-RAY DIFFRACTION158chain 'S' and (resid 76 through 90 )
159X-RAY DIFFRACTION159chain 'S' and (resid 91 through 101 )
160X-RAY DIFFRACTION160chain 'S' and (resid 102 through 113 )
161X-RAY DIFFRACTION161chain 'S' and (resid 114 through 128 )
162X-RAY DIFFRACTION162chain 'S' and (resid 129 through 150 )
163X-RAY DIFFRACTION163chain 'S' and (resid 151 through 163 )
164X-RAY DIFFRACTION164chain 'S' and (resid 164 through 197 )
165X-RAY DIFFRACTION165chain 'S' and (resid 198 through 213 )
166X-RAY DIFFRACTION166chain 'T' and (resid 1 through 77 )
167X-RAY DIFFRACTION167chain 'T' and (resid 78 through 139 )
168X-RAY DIFFRACTION168chain 'T' and (resid 140 through 190 )
169X-RAY DIFFRACTION169chain 'T' and (resid 191 through 218 )
170X-RAY DIFFRACTION170chain 'Y' and (resid 30 through 40 )
171X-RAY DIFFRACTION171chain 'Y' and (resid 41 through 49 )
172X-RAY DIFFRACTION172chain 'Y' and (resid 50 through 70 )
173X-RAY DIFFRACTION173chain 'Y' and (resid 71 through 82 )
174X-RAY DIFFRACTION174chain 'Y' and (resid 83 through 94 )
175X-RAY DIFFRACTION175chain 'Y' and (resid 95 through 110 )
176X-RAY DIFFRACTION176chain 'Y' and (resid 111 through 118 )
177X-RAY DIFFRACTION177chain 'Y' and (resid 119 through 127 )
178X-RAY DIFFRACTION178chain 'Y' and (resid 128 through 133 )
179X-RAY DIFFRACTION179chain 'Y' and (resid 134 through 139 )
180X-RAY DIFFRACTION180chain 'Y' and (resid 140 through 146 )

+
About Yorodumi

-
News

-
Feb 9, 2022. New format data for meta-information of EMDB entries

New format data for meta-information of EMDB entries

  • Version 3 of the EMDB header file is now the official format.
  • The previous official version 1.9 will be removed from the archive.

Related info.:EMDB header

External links:wwPDB to switch to version 3 of the EMDB data model

-
Aug 12, 2020. Covid-19 info

Covid-19 info

URL: https://pdbj.org/emnavi/covid19.php

New page: Covid-19 featured information page in EM Navigator.

Related info.:Covid-19 info / Mar 5, 2020. Novel coronavirus structure data

+
Mar 5, 2020. Novel coronavirus structure data

Novel coronavirus structure data

Related info.:Yorodumi Speices / Aug 12, 2020. Covid-19 info

External links:COVID-19 featured content - PDBj / Molecule of the Month (242)：Coronavirus Proteases

+
Jan 31, 2019. EMDB accession codes are about to change! (news from PDBe EMDB page)

EMDB accession codes are about to change! (news from PDBe EMDB page)

  • The allocation of 4 digits for EMDB accession codes will soon come to an end. Whilst these codes will remain in use, new EMDB accession codes will include an additional digit and will expand incrementally as the available range of codes is exhausted. The current 4-digit format prefixed with “EMD-” (i.e. EMD-XXXX) will advance to a 5-digit format (i.e. EMD-XXXXX), and so on. It is currently estimated that the 4-digit codes will be depleted around Spring 2019, at which point the 5-digit format will come into force.
  • The EM Navigator/Yorodumi systems omit the EMD- prefix.

Related info.:Q: What is EMD? / ID/Accession-code notation in Yorodumi/EM Navigator

External links:EMDB Accession Codes are Changing Soon! / Contact to PDBj

+
Jul 12, 2017. Major update of PDB

Major update of PDB

  • wwPDB released updated PDB data conforming to the new PDBx/mmCIF dictionary.
  • This is a major update changing the version number from 4 to 5, and with Remediation, in which all the entries are updated.
  • In this update, many items about electron microscopy experimental information are reorganized (e.g. em_software).
  • Now, EM Navigator and Yorodumi are based on the updated data.

External links:wwPDB Remediation / Enriched Model Files Conforming to OneDep Data Standards Now Available in the PDB FTP Archive

-
Yorodumi

Thousand views of thousand structures

  • Yorodumi is a browser for structure data from EMDB, PDB, SASBDB, etc.
  • This page is also the successor to EM Navigator detail page, and also detail information page/front-end page for Omokage search.
  • The word "yorodu" (or yorozu) is an old Japanese word meaning "ten thousand". "mi" (miru) is to see.

Related info.:EMDB / PDB / SASBDB / Comparison of 3 databanks / Yorodumi Search / Aug 31, 2016. New EM Navigator & Yorodumi / Yorodumi Papers / Jmol/JSmol / Function and homology information / Changes in new EM Navigator and Yorodumi

Read more