- PDB-8ag2: Crystal structure of the BPTF bromodomain in complex with BI-7190 -
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基本情報
登録情報
データベース: PDB / ID: 8ag2
タイトル
Crystal structure of the BPTF bromodomain in complex with BI-7190
要素
Nucleosome-remodeling factor subunit BPTF
キーワード
PROTEIN BINDING / Bromodomain / Inhibitor / Complex
機能・相同性
機能・相同性情報
NURF complex / endoderm development / anterior/posterior pattern specification / ATPase complex / embryonic placenta development / methylated histone binding / cellular response to nerve growth factor stimulus / brain development / cell body / sequence-specific DNA binding ...NURF complex / endoderm development / anterior/posterior pattern specification / ATPase complex / embryonic placenta development / methylated histone binding / cellular response to nerve growth factor stimulus / brain development / cell body / sequence-specific DNA binding / chromatin remodeling / RNA polymerase II cis-regulatory region sequence-specific DNA binding / dendrite / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / perinuclear region of cytoplasm / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / extracellular exosome / nucleoplasm / nucleus / metal ion binding / cytoplasm 類似検索 - 分子機能
解像度: 1.025→38.78 Å / Cor.coef. Fo:Fc: 0.972 / Cor.coef. Fo:Fc free: 0.97 / SU R Cruickshank DPI: 0.029 / 交差検証法: THROUGHOUT / SU R Blow DPI: 0.03 / SU Rfree Blow DPI: 0.031 / SU Rfree Cruickshank DPI: 0.029