登録情報 | データベース: PDB / ID: 8a8r |
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タイトル | Crystal structure of TEAD4 in complex with YAP peptide |
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要素 | - Isoform 7 of Transcriptional coactivator YAP1
- Transcriptional enhancer factor TEF-3
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キーワード | TRANSCRIPTION / Complex |
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機能・相同性 | 機能・相同性情報
trophectodermal cell fate commitment / enterocyte differentiation / regulation of keratinocyte proliferation / regulation of metanephric nephron tubule epithelial cell differentiation / cardiac muscle tissue regeneration / glandular epithelial cell differentiation / TEAD-YAP complex / lateral mesoderm development / RUNX3 regulates YAP1-mediated transcription / bud elongation involved in lung branching ...trophectodermal cell fate commitment / enterocyte differentiation / regulation of keratinocyte proliferation / regulation of metanephric nephron tubule epithelial cell differentiation / cardiac muscle tissue regeneration / glandular epithelial cell differentiation / TEAD-YAP complex / lateral mesoderm development / RUNX3 regulates YAP1-mediated transcription / bud elongation involved in lung branching / polarized epithelial cell differentiation / notochord development / negative regulation of cilium assembly / lung epithelial cell differentiation / YAP1- and WWTR1 (TAZ)-stimulated gene expression / heart process / trophectodermal cell differentiation / paraxial mesoderm development / regulation of stem cell proliferation / tissue homeostasis / hippo signaling / EGR2 and SOX10-mediated initiation of Schwann cell myelination / intestinal epithelial cell development / negative regulation of epithelial cell apoptotic process / negative regulation of stem cell differentiation / Formation of axial mesoderm / embryonic heart tube morphogenesis / female germ cell nucleus / Differentiation of keratinocytes in interfollicular epidermis in mammalian skin / proline-rich region binding / Signaling by Hippo / cell fate specification / muscle organ development / negative regulation of epithelial cell differentiation / organ growth / interleukin-6-mediated signaling pathway / positive regulation of Notch signaling pathway / negative regulation of fat cell differentiation / positive regulation of stem cell population maintenance / RUNX2 regulates osteoblast differentiation / Zygotic genome activation (ZGA) / somatic stem cell population maintenance / regulation of neurogenesis / canonical Wnt signaling pathway / vasculogenesis / embryonic organ development / positive regulation of osteoblast differentiation / cellular response to retinoic acid / extrinsic apoptotic signaling pathway / Nuclear signaling by ERBB4 / positive regulation of epithelial cell proliferation / keratinocyte differentiation / positive regulation of cardiac muscle cell proliferation / transcription coregulator activity / epithelial cell proliferation / embryo implantation / skeletal system development / response to progesterone / negative regulation of extrinsic apoptotic signaling pathway / wound healing / cell morphogenesis / cellular response to gamma radiation / positive regulation of protein localization to nucleus / positive regulation of canonical Wnt signaling pathway / transcription corepressor activity / cell junction / cell-cell junction / RUNX1 regulates transcription of genes involved in differentiation of HSCs / positive regulation of cell growth / DNA-binding transcription activator activity, RNA polymerase II-specific / DNA-binding transcription factor binding / transcription regulator complex / protein-containing complex assembly / transcription coactivator activity / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of gene expression / chromatin binding / DNA-templated transcription / DNA damage response / regulation of transcription by RNA polymerase II / positive regulation of gene expression / positive regulation of DNA-templated transcription / chromatin / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / nucleoplasm / membrane / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Transcriptional enhancer factor TEF-3 (TEAD4) / : / : / TEA/ATTS domain / Transcriptional enhancer factor, metazoa / TEA/ATTS domain superfamily / TEA/ATTS domain / TEA domain signature. / TEA domain profile. / TEA domain ...Transcriptional enhancer factor TEF-3 (TEAD4) / : / : / TEA/ATTS domain / Transcriptional enhancer factor, metazoa / TEA/ATTS domain superfamily / TEA/ATTS domain / TEA domain signature. / TEA domain profile. / TEA domain / YAP binding domain / YAP binding domain / WW domain / WW/rsp5/WWP domain signature. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain類似検索 - ドメイン・相同性 MYRISTIC ACID / Transcriptional coactivator YAP1 / Transcriptional enhancer factor TEF-3類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.696 Å |
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データ登録者 | Scheufler, C. / Kallen, J. |
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資金援助 | 1件 |
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引用 | ジャーナル: Protein Sci. / 年: 2023 タイトル: N-terminal beta-strand in YAP is critical for stronger binding to scalloped relative to TEAD transcription factor. 著者: Fedir, B. / Yannick, M. / Marco, M. / Patrizia, F. / Catherine, Z. / Frederic, V. / Dirk, E. / Joerg, K. / Clemens, S. / Camilo, V.V. / Patrick, C. |
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履歴 | 登録 | 2022年6月23日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2022年12月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年1月11日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.title ..._citation.journal_volume / _citation.title / _citation.year / _citation_author.name |
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改定 1.2 | 2024年5月1日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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