Entry Database : PDB / ID : 8a8q Structure visualization Downloads & linksTitle Crystal structure of Protein Scalloped in complex with YAP peptide ComponentsIsoform 7 of Transcriptional coactivator YAP1 Protein scalloped DetailsKeywords TRANSCRIPTION / ComplexFunction / homology Function and homology informationFunction Domain/homology Component
: / Transcriptional activation by YKI / : / imaginal disc-derived leg morphogenesis / somatic muscle development / compound eye morphogenesis / regulation of heart morphogenesis / wing disc development / enterocyte differentiation / regulation of keratinocyte proliferation ... : / Transcriptional activation by YKI / : / imaginal disc-derived leg morphogenesis / somatic muscle development / compound eye morphogenesis / regulation of heart morphogenesis / wing disc development / enterocyte differentiation / regulation of keratinocyte proliferation / imaginal disc-derived wing morphogenesis / regulation of metanephric nephron tubule epithelial cell differentiation / cardiac muscle tissue regeneration / glandular epithelial cell differentiation / TEAD-YAP complex / lateral mesoderm development / RUNX3 regulates YAP1-mediated transcription / bud elongation involved in lung branching / polarized epithelial cell differentiation / sensory organ development / notochord development / negative regulation of cilium assembly / lung epithelial cell differentiation / YAP1- and WWTR1 (TAZ)-stimulated gene expression / heart process / trophectodermal cell differentiation / paraxial mesoderm development / regulation of stem cell proliferation / hippo signaling / tissue homeostasis / EGR2 and SOX10-mediated initiation of Schwann cell myelination / intestinal epithelial cell development / negative regulation of epithelial cell apoptotic process / Formation of axial mesoderm / negative regulation of stem cell differentiation / embryonic heart tube morphogenesis / female germ cell nucleus / proline-rich region binding / Signaling by Hippo / cardiac muscle cell development / negative regulation of epithelial cell differentiation / negative regulation of neuroblast proliferation / organ growth / interleukin-6-mediated signaling pathway / positive regulation of stem cell population maintenance / positive regulation of Notch signaling pathway / negative regulation of fat cell differentiation / RUNX2 regulates osteoblast differentiation / Zygotic genome activation (ZGA) / somatic stem cell population maintenance / regulation of neurogenesis / canonical Wnt signaling pathway / vasculogenesis / embryonic organ development / positive regulation of osteoblast differentiation / cellular response to retinoic acid / extrinsic apoptotic signaling pathway / Nuclear signaling by ERBB4 / keratinocyte differentiation / positive regulation of cardiac muscle cell proliferation / transcription corepressor binding / epithelial cell proliferation / stem cell proliferation / positive regulation of epithelial cell proliferation / response to progesterone / negative regulation of extrinsic apoptotic signaling pathway / wound healing / cell morphogenesis / cellular response to gamma radiation / transcription coactivator binding / positive regulation of protein localization to nucleus / RNA polymerase II transcription regulator complex / transcription corepressor activity / cell-cell junction / positive regulation of canonical Wnt signaling pathway / cell junction / RUNX1 regulates transcription of genes involved in differentiation of HSCs / positive regulation of cell growth / protein-containing complex assembly / DNA-binding transcription factor binding / transcription regulator complex / transcription coactivator activity / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / cell cycle / RNA polymerase II cis-regulatory region sequence-specific DNA binding / protein domain specific binding / negative regulation of gene expression / negative regulation of DNA-templated transcription / DNA damage response / chromatin binding / positive regulation of gene expression / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / nucleoplasm / membrane / nucleus / metal ion binding Similarity search - Function TEA/ATTS domain / Transcriptional enhancer factor, metazoa / TEA/ATTS domain superfamily / TEA/ATTS domain / TEA domain signature. / TEA domain profile. / TEA domain / YAP binding domain / YAP binding domain / WW domain ... TEA/ATTS domain / Transcriptional enhancer factor, metazoa / TEA/ATTS domain superfamily / TEA/ATTS domain / TEA domain signature. / TEA domain profile. / TEA domain / YAP binding domain / YAP binding domain / WW domain / WW/rsp5/WWP domain signature. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain Similarity search - Domain/homologyBiological species Drosophila melanogaster (fruit fly)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.465 Å DetailsAuthors Scheufler, C. / Villard, F. Funding support 1items Details Hide detailsOrganization Grant number Country Not funded
CitationJournal : Protein Sci. / Year : 2023Title : N-terminal beta-strand in YAP is critical for stronger binding to scalloped relative to TEAD transcription factor.Authors : Fedir, B. / Yannick, M. / Marco, M. / Patrizia, F. / Catherine, Z. / Frederic, V. / Dirk, E. / Joerg, K. / Clemens, S. / Camilo, V.V. / Patrick, C. History Deposition Jun 23, 2022 Deposition site : PDBE / Processing site : PDBERevision 1.0 Dec 28, 2022 Provider : repository / Type : Initial releaseRevision 1.1 Jan 11, 2023 Group : Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.title ... _citation.journal_volume / _citation.title / _citation.year / _citation_author.name Revision 1.2 May 1, 2024 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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