Entry | Database: PDB / ID: 7zvd |
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Title | K89 acetylated glucose-6-phosphate dehydrogenase (G6PD) in a complex with structural NADP+ |
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Components | Glucose-6-phosphate 1-dehydrogenase |
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Keywords | OXIDOREDUCTASE / Lysine acetylation / metabolic regulation / post-translational modification / genetic code expansion |
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Function / homology | Function and homology information
negative regulation of protein glutathionylation / pentose biosynthetic process / ribose phosphate biosynthetic process / glucose-6-phosphate dehydrogenase (NADP+) / positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel / glucose-6-phosphate dehydrogenase activity / response to iron(III) ion / Pentose phosphate pathway / pentose-phosphate shunt, oxidative branch / NADPH regeneration ...negative regulation of protein glutathionylation / pentose biosynthetic process / ribose phosphate biosynthetic process / glucose-6-phosphate dehydrogenase (NADP+) / positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel / glucose-6-phosphate dehydrogenase activity / response to iron(III) ion / Pentose phosphate pathway / pentose-phosphate shunt, oxidative branch / NADPH regeneration / negative regulation of cell growth involved in cardiac muscle cell development / glucose 6-phosphate metabolic process / NADP metabolic process / pentose-phosphate shunt / D-glucose binding / NFE2L2 regulates pentose phosphate pathway genes / response to food / erythrocyte maturation / cholesterol biosynthetic process / centriolar satellite / negative regulation of reactive oxygen species metabolic process / regulation of neuron apoptotic process / substantia nigra development / glutathione metabolic process / lipid metabolic process / TP53 Regulates Metabolic Genes / response to organic cyclic compound / cytoplasmic side of plasma membrane / glucose metabolic process / NADP binding / cellular response to oxidative stress / response to ethanol / intracellular membrane-bounded organelle / protein homodimerization activity / extracellular exosome / identical protein binding / membrane / cytoplasm / cytosolSimilarity search - Function Glucose-6-phosphate dehydrogenase, active site / Glucose-6-phosphate dehydrogenase active site. / Glucose-6-phosphate dehydrogenase / Glucose-6-phosphate dehydrogenase, NAD-binding / Glucose-6-phosphate dehydrogenase, C-terminal / Glucose-6-phosphate dehydrogenase, NAD binding domain / Glucose-6-phosphate dehydrogenase, C-terminal domain / NAD(P)-binding domain superfamilySimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.46 Å |
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Authors | Wu, F. / Muskat, N.H. / Nudelman, H. / Shahar, A. / Arbely, E. |
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Funding support | European Union, Israel, 2items Organization | Grant number | Country |
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European Research Council (ERC) | 678461 | European Union | Israel Science Foundation | 1769/20 | Israel |
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Citation | Journal: Nat Commun / Year: 2023 Title: Acetylation-dependent coupling between G6PD activity and apoptotic signaling. Authors: Wu, F. / Muskat, N.H. / Dvilansky, I. / Koren, O. / Shahar, A. / Gazit, R. / Elia, N. / Arbely, E. |
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History | Deposition | May 15, 2022 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Aug 23, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 15, 2023 | Group: Data collection / Category: chem_comp_atom / chem_comp_bond / Item: _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2 |
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Revision 1.2 | Feb 7, 2024 | Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.3 | Feb 28, 2024 | Group: Source and taxonomy / Category: entity_src_gen Item: _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id / _entity_src_gen.pdbx_gene_src_scientific_name |
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