登録情報 | データベース: PDB / ID: 7zry |
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タイトル | Structure of the 2a splicing variant of the full-length human LSD1 bound to CoREST (delta305) |
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要素 | - Isoform of Lysine-specific histone demethylase 1A
- REST corepressor 1
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キーワード | FLAVOPROTEIN / demethylase / histone / splicing / epigenetics |
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機能・相同性 | 機能・相同性情報
positive regulation of megakaryocyte differentiation / DNA repair complex / histone deacetylase complex / transcription repressor complex / erythrocyte differentiation / Regulation of PTEN gene transcription / HDACs deacetylate histones / transcription corepressor activity / chromatin organization / Factors involved in megakaryocyte development and platelet production ...positive regulation of megakaryocyte differentiation / DNA repair complex / histone deacetylase complex / transcription repressor complex / erythrocyte differentiation / Regulation of PTEN gene transcription / HDACs deacetylate histones / transcription corepressor activity / chromatin organization / Factors involved in megakaryocyte development and platelet production / transcription regulator complex / Potential therapeutics for SARS / negative regulation of gene expression / negative regulation of DNA-templated transcription / chromatin binding / regulation of transcription by RNA polymerase II / enzyme binding / nucleoplasm / nucleus類似検索 - 分子機能 : / : / Helical region in REST corepressor / ELM2 domain / ELM2 domain / ELM2 domain profile. / ELM2 / SANT domain profile. / SANT domain / Myb-like DNA-binding domain ...: / : / Helical region in REST corepressor / ELM2 domain / ELM2 domain / ELM2 domain profile. / ELM2 / SANT domain profile. / SANT domain / Myb-like DNA-binding domain / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain / Homeobox-like domain superfamily類似検索 - ドメイン・相同性 FLAVIN-ADENINE DINUCLEOTIDE / REST corepressor 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.7 Å |
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データ登録者 | Caroli, J. / Mattevi, A. |
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資金援助 | サウジアラビア, 1件 組織 | 認可番号 | 国 |
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Other government | OSR-2019-CRG8-4012.2 | サウジアラビア |
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引用 | ジャーナル: Iscience / 年: 2022 タイトル: Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism. 著者: Astro, V. / Ramirez-Calderon, G. / Pennucci, R. / Caroli, J. / Saera-Vila, A. / Cardona-Londono, K. / Forastieri, C. / Fiacco, E. / Maksoud, F. / Alowaysi, M. / Sogne, E. / Falqui, A. / ...著者: Astro, V. / Ramirez-Calderon, G. / Pennucci, R. / Caroli, J. / Saera-Vila, A. / Cardona-Londono, K. / Forastieri, C. / Fiacco, E. / Maksoud, F. / Alowaysi, M. / Sogne, E. / Falqui, A. / Gonzalez, F. / Montserrat, N. / Battaglioli, E. / Mattevi, A. / Adamo, A. |
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履歴 | 登録 | 2022年5月6日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2022年8月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月31日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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