Entry Database : PDB / ID : 7yxw Structure visualization Downloads & linksTitle Structure of the p22phox A200G mutant in complex with p47phox peptide ComponentsCytochrome b-245 light chain Neutrophil cytosol factor 1 DetailsKeywords OXIDOREDUCTASE / NADPH oxidase complex / oxidoreductase activatorFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of glomerular filtration by angiotensin / smooth muscle hypertrophy / regulation of respiratory burst involved in inflammatory response / neutrophil-mediated killing of gram-positive bacterium / superoxide-generating NADPH oxidase activator activity / cellular response to L-glutamine / neutrophil-mediated killing of fungus / phagolysosome / positive regulation of toll-like receptor 2 signaling pathway / positive regulation of defense response to bacterium ... negative regulation of glomerular filtration by angiotensin / smooth muscle hypertrophy / regulation of respiratory burst involved in inflammatory response / neutrophil-mediated killing of gram-positive bacterium / superoxide-generating NADPH oxidase activator activity / cellular response to L-glutamine / neutrophil-mediated killing of fungus / phagolysosome / positive regulation of toll-like receptor 2 signaling pathway / positive regulation of defense response to bacterium / mucus secretion / perinuclear endoplasmic reticulum / superoxide-generating NAD(P)H oxidase activity / leukotriene metabolic process / response to yeast / Cross-presentation of particulate exogenous antigens (phagosomes) / NADPH oxidase complex / cytochrome complex assembly / cellular response to testosterone stimulus / respiratory burst / WNT5:FZD7-mediated leishmania damping / respiratory burst involved in defense response / phosphatidylinositol-3,4-bisphosphate binding / ROS and RNS production in phagocytes / regulation of release of sequestered calcium ion into cytosol / hydrogen peroxide biosynthetic process / protein targeting to membrane / superoxide anion generation / positive regulation of mucus secretion / superoxide metabolic process / response to aldosterone / Detoxification of Reactive Oxygen Species / positive regulation of reactive oxygen species biosynthetic process / tertiary granule membrane / cellular response to angiotensin / RHO GTPases Activate NADPH Oxidases / RAC2 GTPase cycle / RAC3 GTPase cycle / cellular defense response / specific granule membrane / stress fiber / positive regulation of phagocytosis / positive regulation of endothelial cell proliferation / RAC1 GTPase cycle / phosphatidylinositol binding / response to interleukin-1 / secretory granule / positive regulation of superoxide anion generation / epithelial cell proliferation / response to activity / response to nutrient levels / positive regulation of smooth muscle cell proliferation / cellular response to glucose stimulus / establishment of localization in cell / cellular response to gamma radiation / SH3 domain binding / positive regulation of interleukin-6 production / VEGFA-VEGFR2 Pathway / cytoplasmic side of plasma membrane / cellular response to mechanical stimulus / phagocytic vesicle membrane / positive regulation of tumor necrosis factor production / cellular response to tumor necrosis factor / positive regulation of cell growth / response to hypoxia / electron transfer activity / endosome / apical plasma membrane / inflammatory response / response to xenobiotic stimulus / protein heterodimerization activity / innate immune response / focal adhesion / neuronal cell body / heme binding / dendrite / Neutrophil degranulation / endoplasmic reticulum membrane / metal ion binding / membrane / plasma membrane / cytosol / cytoplasm Similarity search - Function Cytochrome b558 alpha-subunit / Cytochrome Cytochrome b558 alpha-subunit / Neutrophil cytosol factor 1 / Neutrophil cytosol factor 1, C-terminal / Neutrophil cytosol factor 1, PBR/AIR / Neutrophil cytosol factor 1, PX domain / Neutrophil cytosol factor 1, first SH3 domain / Neutrophil cytosol factor 1, second SH3 domain / NADPH oxidase subunit p47Phox, C terminal domain / Neutrophil cytosol factor 1, PBR/AIR ... Cytochrome b558 alpha-subunit / Cytochrome Cytochrome b558 alpha-subunit / Neutrophil cytosol factor 1 / Neutrophil cytosol factor 1, C-terminal / Neutrophil cytosol factor 1, PBR/AIR / Neutrophil cytosol factor 1, PX domain / Neutrophil cytosol factor 1, first SH3 domain / Neutrophil cytosol factor 1, second SH3 domain / NADPH oxidase subunit p47Phox, C terminal domain / Neutrophil cytosol factor 1, PBR/AIR / : / PhoX homologous domain, present in p47phox and p40phox. / PX domain profile. / PX domain / Phox homology / PX domain superfamily / SH3 domain / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.5 Å DetailsAuthors Cukier, C.D. / Vuillard, L.M. / Komjati, B. / Szlavik, Z. Funding support 1items Details Hide detailsOrganization Grant number Country Not funded
CitationJournal : Acs Med.Chem.Lett. / Year : 2022Title : Targeting NOX2 via p47/phox-p22/phox Inhibition with Novel Triproline MimeticsAuthors: Garsi, J.B. / Komjati, B. / Cullia, G. / Fejes, I. / Sipos, M. / Sipos, Z. / Fordos, E. / Markacz, P. / Balazs, B. / Lancelot, N. / Berger, S. / Raimbaud, E. / Brown, D. / Vuillard, L.M. / ... Authors : Garsi, J.B. / Komjati, B. / Cullia, G. / Fejes, I. / Sipos, M. / Sipos, Z. / Fordos, E. / Markacz, P. / Balazs, B. / Lancelot, N. / Berger, S. / Raimbaud, E. / Brown, D. / Vuillard, L.M. / Haberkorn, L. / Cukier, C. / Szlavik, Z. / Hanessian, S. History Deposition Feb 16, 2022 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 30, 2022 Provider : repository / Type : Initial releaseRevision 1.1 Jun 22, 2022 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _citation.year Revision 1.2 Jan 31, 2024 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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