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Yorodumi- PDB-7y9n: an engineered 5-helix bundle derived from SARS-CoV-2 S2 in comple... -
+Open data
-Basic information
Entry | Database: PDB / ID: 7y9n | ||||||
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Title | an engineered 5-helix bundle derived from SARS-CoV-2 S2 in complex with HR2P | ||||||
Components |
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Keywords | VIRUS PROTEIN/INHIBITOR / 5HB / VIRUS PROTEIN-INHIBITOR complex | ||||||
Function / homology | Function and homology information Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell ...Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / receptor-mediated endocytosis of virus by host cell / membrane fusion / Attachment and Entry / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / receptor ligand activity / symbiont-mediated suppression of host innate immune response / host cell surface receptor binding / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / virion membrane / identical protein binding / membrane / plasma membrane Similarity search - Function | ||||||
Biological species | Severe acute respiratory syndrome coronavirus 2 | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.885 Å | ||||||
Authors | Lu, G.W. / Lin, X. / Guo, L.Y. / Lin, S. | ||||||
Funding support | China, 1items
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Citation | Journal: Emerg Microbes Infect / Year: 2022 Title: An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry. Authors: Lin, X. / Guo, L. / Lin, S. / Chen, Z. / Yang, F. / Yang, J. / Wang, L. / Wen, A. / Duan, Y. / Zhang, X. / Dai, Y. / Yin, K. / Yuan, X. / Yu, C. / He, B. / Cao, Y. / Dong, H. / Li, J. / Zhao, Q. / Lu, G. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7y9n.cif.gz | 106 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7y9n.ent.gz | 79.1 KB | Display | PDB format |
PDBx/mmJSON format | 7y9n.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7y9n_validation.pdf.gz | 436 KB | Display | wwPDB validaton report |
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Full document | 7y9n_full_validation.pdf.gz | 438.4 KB | Display | |
Data in XML | 7y9n_validation.xml.gz | 10.9 KB | Display | |
Data in CIF | 7y9n_validation.cif.gz | 14.7 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/y9/7y9n ftp://data.pdbj.org/pub/pdb/validation_reports/y9/7y9n | HTTPS FTP |
-Related structure data
Related structure data | 6lxtS S: Starting model for refinement |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Components on special symmetry positions |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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