登録情報 | データベース: PDB / ID: 7xy8 |
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タイトル | Crystal structure of antibody Fab fragment in complex with CD147(EMMPIRIN) |
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要素 | - Isoform 2 of Basigin
- heavy chain
- light chain
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キーワード | PROTEIN BINDING / cd147 / complex / antibody |
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機能・相同性 | 機能・相同性情報
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) / Proton-coupled monocarboxylate transport / positive regulation of matrix metallopeptidase secretion / acrosomal membrane / dendrite self-avoidance / response to mercury ion / cell-cell adhesion mediator activity / endothelial tube morphogenesis / neural retina development / Pyruvate metabolism ...Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) / Proton-coupled monocarboxylate transport / positive regulation of matrix metallopeptidase secretion / acrosomal membrane / dendrite self-avoidance / response to mercury ion / cell-cell adhesion mediator activity / endothelial tube morphogenesis / neural retina development / Pyruvate metabolism / photoreceptor cell maintenance / Basigin interactions / Aspirin ADME / odontogenesis of dentin-containing tooth / homophilic cell adhesion via plasma membrane adhesion molecules / D-mannose binding / decidualization / photoreceptor outer segment / positive regulation of vascular endothelial growth factor production / Integrin cell surface interactions / response to cAMP / embryo implantation / Degradation of the extracellular matrix / photoreceptor inner segment / positive regulation of endothelial cell migration / neutrophil chemotaxis / protein localization to plasma membrane / axon guidance / sarcolemma / response to peptide hormone / positive regulation of interleukin-6 production / melanosome / virus receptor activity / signaling receptor activity / basolateral plasma membrane / angiogenesis / positive regulation of viral entry into host cell / cell surface receptor signaling pathway / endosome / cadherin binding / axon / Golgi membrane / intracellular membrane-bounded organelle / focal adhesion / endoplasmic reticulum membrane / mitochondrion / extracellular exosome / membrane / plasma membrane類似検索 - 分子機能 Immunoglobulin domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) synthetic construct (人工物) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.3 Å |
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データ登録者 | Nakamura, K. / Amano, M. / Yoneda, K. / Suzuki, M. / Fukuchi, K. |
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資金援助 | 1件 |
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引用 | ジャーナル: J Oncol / 年: 2022 タイトル: Novel Antibody Exerts Antitumor Effect through Downregulation of CD147 and Activation of Multiple Stress Signals. 著者: Fukuchi, K. / Nanai, K. / Yuita, H. / Maru, C. / Tsukada, J. / Ishigami, M. / Nagai, Y. / Nakano, Y. / Yoshimura, C. / Yoneda, K. / Amano, M. / Nakamura, K. / Oda, Y. / Nishigohri, H. / ...著者: Fukuchi, K. / Nanai, K. / Yuita, H. / Maru, C. / Tsukada, J. / Ishigami, M. / Nagai, Y. / Nakano, Y. / Yoshimura, C. / Yoneda, K. / Amano, M. / Nakamura, K. / Oda, Y. / Nishigohri, H. / Yamamoto, S. / Ohnishi-Totoki, Y. / Inaki, K. / Komori, H. / Nakano, R. / Kanari, Y. / Nishida, A. / Matsui, Y. / Funo, S. / Takahashi, S. / Ohtsuka, T. / Agatsuma, T. |
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履歴 | 登録 | 2022年6月1日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2022年11月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月29日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _citation.country / _citation.journal_id_ISSN ..._citation.country / _citation.journal_id_ISSN / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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改定 1.2 | 2024年5月1日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title |
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