登録情報 | データベース: PDB / ID: 7xgk |
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タイトル | Human renin in complex with compound1 |
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要素 | Renin |
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キーワード | HYDROLASE/INHIBITOR / HYDROLASE-INHIBITOR COMPLEX |
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機能・相同性 | 機能・相同性情報
renin / juxtaglomerular apparatus development / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / amyloid-beta metabolic process / angiotensin maturation ...renin / juxtaglomerular apparatus development / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / amyloid-beta metabolic process / angiotensin maturation / Metabolism of Angiotensinogen to Angiotensins / cell maturation / response to cAMP / insulin-like growth factor receptor binding / hormone-mediated signaling pathway / kidney development / regulation of blood pressure / male gonad development / cellular response to xenobiotic stimulus / apical part of cell / peptidase activity / response to lipopolysaccharide / aspartic-type endopeptidase activity / signaling receptor binding / proteolysis / extracellular space / extracellular region / plasma membrane類似検索 - 分子機能 Renin-like domain / Aspartic peptidase, N-terminal / A1 Propeptide / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 2.4 Å |
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データ登録者 | Kashima, A. |
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資金援助 | 1件 |
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引用 | ジャーナル: Acs Med.Chem.Lett. / 年: 2022 タイトル: Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors. 著者: Iijima, D. / Sugama, H. / Awai, N. / Takahashi, Y. / Togashi, Y. / Takebe, T. / Xie, J. / Shen, J. / Ke, Y. / Akatsuka, H. / Kawaguchi, T. / Takedomi, K. / Kashima, A. / Nishio, M. / Inui, Y. ...著者: Iijima, D. / Sugama, H. / Awai, N. / Takahashi, Y. / Togashi, Y. / Takebe, T. / Xie, J. / Shen, J. / Ke, Y. / Akatsuka, H. / Kawaguchi, T. / Takedomi, K. / Kashima, A. / Nishio, M. / Inui, Y. / Yoneda, H. / Xia, G. / Iijima, T. |
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履歴 | 登録 | 2022年4月5日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2022年8月31日 | Provider: repository / タイプ: Initial release |
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