登録情報 | データベース: PDB / ID: 7x9q |
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タイトル | Crystal structure of human STING complexed with compound BSP16 |
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要素 | Stimulator of interferon genes protein |
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キーワード | IMMUNE SYSTEM / STING agonists |
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機能・相同性 | 機能・相同性情報
STING complex / STAT6-mediated induction of chemokines / protein localization to endoplasmic reticulum / serine/threonine protein kinase complex / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway ...STING complex / STAT6-mediated induction of chemokines / protein localization to endoplasmic reticulum / serine/threonine protein kinase complex / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway / cGAS/STING signaling pathway / reticulophagy / pattern recognition receptor signaling pathway / cytoplasmic pattern recognition receptor signaling pathway / cellular response to exogenous dsRNA / autophagosome membrane / antiviral innate immune response / positive regulation of macroautophagy / cellular response to organic cyclic compound / autophagosome assembly / autophagosome / positive regulation of type I interferon production / cellular response to interferon-beta / signaling adaptor activity / positive regulation of defense response to virus by host / activation of innate immune response / Regulation of innate immune responses to cytosolic DNA / positive regulation of interferon-beta production / endoplasmic reticulum-Golgi intermediate compartment membrane / secretory granule membrane / cytoplasmic vesicle membrane / positive regulation of DNA-binding transcription factor activity / peroxisome / SARS-CoV-1 activates/modulates innate immune responses / positive regulation of protein binding / protein complex oligomerization / regulation of inflammatory response / defense response to virus / RNA polymerase II-specific DNA-binding transcription factor binding / mitochondrial outer membrane / endosome / Golgi membrane / innate immune response / ubiquitin protein ligase binding / Neutrophil degranulation / endoplasmic reticulum membrane / protein kinase binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / perinuclear region of cytoplasm / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / plasma membrane / cytosol類似検索 - 分子機能 : / Stimulator of interferon genes protein / Stimulator of interferon genes protein, C-terminal domain superfamily / Transmembrane protein 173類似検索 - ドメイン・相同性 Chem-A9X / Stimulator of interferon genes protein類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.4 Å |
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データ登録者 | Pan, L. / Guan, X. / Feng, X. / Li, Z. / Bian, J. |
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資金援助 | 中国, 5件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | 31860245 | 中国 | National Natural Science Foundation of China (NSFC) | 31960203 | 中国 | National Natural Science Foundation of China (NSFC) | 82073702 | 中国 | National Natural Science Foundation of China (NSFC) | 32070387 | 中国 | National Natural Science Foundation of China (NSFC) | 81872746 | 中国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2022 タイトル: Discovery of Selenium-Containing STING Agonists as Orally Available Antitumor Agents. 著者: Feng, X. / Pan, L. / Qian, Z. / Liu, D. / Guan, X. / Feng, L. / Song, B. / Xu, X. / Tan, N. / Ma, Y. / Li, Z. / Wang, Z. / Bian, J. |
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履歴 | 登録 | 2022年3月15日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2022年9月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年12月7日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.2 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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