登録情報 | データベース: PDB / ID: 7x9g |
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タイトル | Crystal structure of human EDA and EDAR |
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要素 | - Ectodysplasin-A, secreted form
- Tumor necrosis factor receptor superfamily member EDAR
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キーワード | MEMBRANE PROTEIN / ligand-receptor complex |
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機能・相同性 | 機能・相同性情報
trachea gland development / animal organ development / salivary gland cavitation / regulation of non-canonical NF-kappaB signal transduction / TNFs bind their physiological receptors / death receptor agonist activity / collagen trimer / tumor necrosis factor receptor binding / death receptor binding / pigmentation ...trachea gland development / animal organ development / salivary gland cavitation / regulation of non-canonical NF-kappaB signal transduction / TNFs bind their physiological receptors / death receptor agonist activity / collagen trimer / tumor necrosis factor receptor binding / death receptor binding / pigmentation / odontogenesis of dentin-containing tooth / hair follicle placode formation / epidermis development / hair follicle development / canonical Wnt signaling pathway / lipid droplet / cell-matrix adhesion / cytokine activity / positive regulation of JNK cascade / positive regulation of non-canonical NF-kappaB signal transduction / cytokine-mediated signaling pathway / apical part of cell / transmembrane signaling receptor activity / positive regulation of canonical Wnt signaling pathway / signaling receptor activity / gene expression / cell differentiation / cytoskeleton / positive regulation of canonical NF-kappaB signal transduction / immune response / receptor ligand activity / signaling receptor binding / intracellular membrane-bounded organelle / apoptotic process / endoplasmic reticulum membrane / positive regulation of gene expression / extracellular space / membrane / plasma membrane類似検索 - 分子機能 Tumor necrosis factor receptor EDAR, N-terminal / : / : / TNF(Tumour Necrosis Factor) family / Tumour necrosis factor domain / Tumor necrosis factor (TNF) homology domain (THD) profile. / Tumour necrosis factor-like domain superfamily / Death-like domain superfamily類似検索 - ドメイン・相同性 Ectodysplasin-A / Tumor necrosis factor receptor superfamily member EDAR類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.8 Å |
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データ登録者 | Yu, K. / Wan, F. / Huang, C. / Wu, J. / Lei, M. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | | 中国 |
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引用 | ジャーナル: Nat Commun / 年: 2023 タイトル: Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants. 著者: Yu, K. / Huang, C. / Wan, F. / Jiang, C. / Chen, J. / Li, X. / Wang, F. / Wu, J. / Lei, M. / Wu, Y. |
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履歴 | 登録 | 2022年3月15日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2023年2月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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改定 1.2 | 2024年11月20日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature |
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