PDB-7x8x: structural insights into Mycobacterium tuberculosis ClpP1P2 inhib...

Basic information

• Entry: Database: PDB / ID: 7x8x
• Title: structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease

Components

• 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide
• ATP-dependent Clp protease proteolytic subunit 1
• ATP-dependent Clp protease proteolytic subunit 2

• Keywords: HYDROLASE/HYDROLASE INHIBITOR / antimicrobial agents / HYDROLASE-HYDROLASE INHIBITOR complex

Function / homology

Function:

endopeptidase Clp / ATP-dependent peptidase activity / serine-type endopeptidase activity / proteolysis / cytoplasm

Domain/homology:

ClpP, Ser active site / Endopeptidase Clp serine active site. / ClpP, histidine active site / Endopeptidase Clp histidine active site. / ATP-dependent Clp protease proteolytic subunit / Clp protease proteolytic subunit /Translocation-enhancing protein TepA / Clp protease / ClpP/crotonase-like domain superfamily

Component:

Chem-AI4 / ATP-dependent Clp protease proteolytic subunit 2 / ATP-dependent Clp protease proteolytic subunit 1

• Biological species: Mycobacterium tuberculosis CDC1551 (bacteria); Mycobacterium tuberculosis (bacteria); synthetic construct (others)
• Method: X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.24 Å
• Authors: Bao, R. / Luo, Y.F. / Zhu, Y.B. / Yang, Y. / Zhou, Y.Z.

Funding support

China, 1items

Organization	Grant number	Country
National Natural Science Foundation of China (NSFC)	81473253	China

• Citation: Journal: J.Med.Chem. / Year: 2023; Title: Discovery and Mechanistic Study of Novel Mycobacterium tuberculosis ClpP1P2 Inhibitors; Authors: Yang, Y. / Zhao, N. / Xu, X. / Zhou, Y. / Luo, B. / Zhang, J. / Sui, J. / Huang, J. / Qiu, Z. / Zhang, X. / Zeng, J. / Bai, L. / Bao, R. / Luo, Y.

History

Deposition	Mar 15, 2022	Deposition site: PDBJ / Processing site: PDBJ
Revision 1.0	Apr 12, 2023	Provider: repository / Type: Initial release
Revision 1.1	Apr 26, 2023	Group: Derived calculations / Category: pdbx_struct_assembly / pdbx_struct_assembly_gen
Revision 1.2	Nov 29, 2023	Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
Revision 1.3	Apr 24, 2024	Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _citation.year

Assembly

Deposited unit

A: ATP-dependent Clp protease proteolytic subunit 2

O: ATP-dependent Clp protease proteolytic subunit 2

B: ATP-dependent Clp protease proteolytic subunit 1

P: ATP-dependent Clp protease proteolytic subunit 1

C: ATP-dependent Clp protease proteolytic subunit 2

Q: ATP-dependent Clp protease proteolytic subunit 2

D: ATP-dependent Clp protease proteolytic subunit 1

R: ATP-dependent Clp protease proteolytic subunit 1

F: ATP-dependent Clp protease proteolytic subunit 2

S: ATP-dependent Clp protease proteolytic subunit 2

H: ATP-dependent Clp protease proteolytic subunit 2

T: ATP-dependent Clp protease proteolytic subunit 2

I: ATP-dependent Clp protease proteolytic subunit 1

U: ATP-dependent Clp protease proteolytic subunit 1

J: ATP-dependent Clp protease proteolytic subunit 2

V: ATP-dependent Clp protease proteolytic subunit 2

K: ATP-dependent Clp protease proteolytic subunit 1

W: ATP-dependent Clp protease proteolytic subunit 1

L: ATP-dependent Clp protease proteolytic subunit 2

X: ATP-dependent Clp protease proteolytic subunit 2

M: ATP-dependent Clp protease proteolytic subunit 1

Y: ATP-dependent Clp protease proteolytic subunit 1

N: ATP-dependent Clp protease proteolytic subunit 1

Z: ATP-dependent Clp protease proteolytic subunit 1

E: ATP-dependent Clp protease proteolytic subunit 2

a: ATP-dependent Clp protease proteolytic subunit 2

G: ATP-dependent Clp protease proteolytic subunit 1

b: ATP-dependent Clp protease proteolytic subunit 1

c: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

e: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

f: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

g: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

h: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

i: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

j: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

k: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

l: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

m: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

n: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

o: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

p: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

q: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

r: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

s: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

t: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

u: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

v: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

w: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

x: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

y: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

z: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

0: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

1: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

2: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

3: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

4: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

hetero molecules

Summary:

• 592 kDa, 56 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	591,966	70
Polymers	583,795	56
Non-polymers	8,171	14
Water	0	0

1

A: ATP-dependent Clp protease proteolytic subunit 2

B: ATP-dependent Clp protease proteolytic subunit 1

C: ATP-dependent Clp protease proteolytic subunit 2

D: ATP-dependent Clp protease proteolytic subunit 1

F: ATP-dependent Clp protease proteolytic subunit 2

H: ATP-dependent Clp protease proteolytic subunit 2

I: ATP-dependent Clp protease proteolytic subunit 1

J: ATP-dependent Clp protease proteolytic subunit 2

K: ATP-dependent Clp protease proteolytic subunit 1

L: ATP-dependent Clp protease proteolytic subunit 2

M: ATP-dependent Clp protease proteolytic subunit 1

N: ATP-dependent Clp protease proteolytic subunit 1

E: ATP-dependent Clp protease proteolytic subunit 2

G: ATP-dependent Clp protease proteolytic subunit 1

c: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

e: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

f: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

g: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

h: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

i: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

j: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

k: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

l: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

m: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

n: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

o: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

p: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

q: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

hetero molecules

Summary:

• defined by author
• Evidence: gel filtration
• 296 kDa, 28 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	295,983	35
Polymers	291,898	28
Non-polymers	4,086	7
Water	0

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

2

O: ATP-dependent Clp protease proteolytic subunit 2

P: ATP-dependent Clp protease proteolytic subunit 1

Q: ATP-dependent Clp protease proteolytic subunit 2

R: ATP-dependent Clp protease proteolytic subunit 1

S: ATP-dependent Clp protease proteolytic subunit 2

T: ATP-dependent Clp protease proteolytic subunit 2

U: ATP-dependent Clp protease proteolytic subunit 1

V: ATP-dependent Clp protease proteolytic subunit 2

W: ATP-dependent Clp protease proteolytic subunit 1

X: ATP-dependent Clp protease proteolytic subunit 2

Y: ATP-dependent Clp protease proteolytic subunit 1

Z: ATP-dependent Clp protease proteolytic subunit 1

a: ATP-dependent Clp protease proteolytic subunit 2

b: ATP-dependent Clp protease proteolytic subunit 1

r: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

s: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

t: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

u: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

v: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

w: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

x: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

y: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

z: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

0: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

1: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

2: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

3: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

4: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

hetero molecules

Summary:

• defined by author
• 296 kDa, 28 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	295,983	35
Polymers	291,898	28
Non-polymers	4,086	7
Water	0

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Unit cell

Length a, b, c (Å)	207.510, 182.500, 188.700
Angle α, β, γ (deg.)	90.000, 95.020, 90.000
Int Tables number	5
Space group name H-M	C121
Space group name Hall	C2y
Symmetry operation	#1: x,y,z #2: -x,y,-z #3: x+1/2,y+1/2,z #4: -x+1/2,y+1/2,-z

Noncrystallographic symmetry (NCS)

NCS domain:

ID	Ens-ID	Details
d_1	ens_1	(chain "A" and ((resid 15 and (name N or name...
d_2	ens_1	(chain "C" and ((resid 15 and (name N or name...
d_3	ens_1	(chain "E" and ((resid 15 and (name N or name...
d_4	ens_1	(chain "F" and ((resid 15 and (name N or name...
d_5	ens_1	(chain "H" and ((resid 15 and (name N or name...
d_6	ens_1	(chain "J" and ((resid 15 and (name N or name...
d_7	ens_1	(chain "L" and ((resid 15 and (name N or name...
d_8	ens_1	(chain "O" and ((resid 15 and (name N or name...
d_9	ens_1	(chain "Q" and ((resid 15 and (name N or name...
d_10	ens_1	(chain "S" and ((resid 15 and (name N or name...
d_11	ens_1	(chain "T" and ((resid 15 and (name N or name...
d_12	ens_1	(chain "V" and ((resid 15 and (name N or name...
d_13	ens_1	(chain "X" and ((resid 15 and (name N or name...
d_14	ens_1	(chain "a" and ((resid 15 and (name N or name...
d_1	ens_2	(chain "B" and ((resid 17 and (name N or name...
d_2	ens_2	(chain "D" and ((resid 17 and (name N or name...
d_3	ens_2	(chain "G" and ((resid 17 and (name N or name...
d_4	ens_2	(chain "I" and ((resid 17 and (name N or name...
d_5	ens_2	(chain "K" and ((resid 17 and (name N or name...
d_6	ens_2	(chain "M" and ((resid 17 and (name N or name...
d_7	ens_2	(chain "N" and ((resid 17 and (name N or name...
d_8	ens_2	(chain "P" and ((resid 17 and (name N or name...
d_9	ens_2	(chain "R" and ((resid 17 and (name N or name...
d_10	ens_2	(chain "U" and ((resid 17 and (name N or name...
d_11	ens_2	(chain "W" and ((resid 17 and (name N or name...
d_12	ens_2	(chain "Y" and ((resid 17 and (name N or name...
d_13	ens_2	(chain "Z" and ((resid 17 and (name N or name...
d_14	ens_2	(chain "b" and ((resid 17 and (name N or name...

NCS domain segments:

Component-ID: 1

Dom-ID	Ens-ID	Beg auth comp-ID	Beg label comp-ID	End auth comp-ID	End label comp-ID	Auth asym-ID	Label asym-ID	Auth seq-ID	Label seq-ID
d_1	ens_1	ILE	ILE	ARG	ARG	A	A	15 - 207	2 - 194
d_2	ens_1	ILE	ILE	ARG	ARG	C	E	15 - 207	2 - 194
d_3	ens_1	ILE	ILE	ARG	ARG	E	Y	15 - 207	2 - 194
d_4	ens_1	ILE	ILE	ARG	ARG	F	I	15 - 207	2 - 194
d_5	ens_1	ILE	ILE	ARG	ARG	H	K	15 - 207	2 - 194
d_6	ens_1	ILE	ILE	ARG	ARG	J	O	15 - 207	2 - 194
d_7	ens_1	ILE	ILE	ARG	ARG	L	S	15 - 207	2 - 194
d_8	ens_1	ILE	ILE	ARG	ARG	O	B	15 - 207	2 - 194
d_9	ens_1	ILE	ILE	ARG	ARG	Q	F	15 - 207	2 - 194
d_10	ens_1	ILE	ILE	ARG	ARG	S	J	15 - 207	2 - 194
d_11	ens_1	ILE	ILE	ARG	ARG	T	L	15 - 207	2 - 194
d_12	ens_1	ILE	ILE	ARG	ARG	V	P	15 - 207	2 - 194
d_13	ens_1	ILE	ILE	ARG	ARG	X	T	15 - 207	2 - 194
d_14	ens_1	ILE	ILE	ARG	ARG	a	Z	15 - 207	2 - 194
d_1	ens_2	THR	THR	THR	THR	B	C	17 - 191	2 - 176
d_2	ens_2	THR	THR	THR	THR	D	G	17 - 191	2 - 176
d_3	ens_2	THR	THR	THR	THR	G	AA	17 - 191	2 - 176
d_4	ens_2	THR	THR	THR	THR	I	M	17 - 191	2 - 176
d_5	ens_2	THR	THR	THR	THR	K	Q	17 - 191	2 - 176
d_6	ens_2	THR	THR	THR	THR	M	U	17 - 191	2 - 176
d_7	ens_2	THR	THR	THR	THR	N	W	17 - 191	2 - 176
d_8	ens_2	THR	THR	THR	THR	P	D	17 - 191	2 - 176
d_9	ens_2	THR	THR	THR	THR	R	H	17 - 191	2 - 176
d_10	ens_2	THR	THR	THR	THR	U	N	17 - 191	2 - 176
d_11	ens_2	THR	THR	THR	THR	W	R	17 - 191	2 - 176
d_12	ens_2	THR	THR	THR	THR	Y	V	17 - 191	2 - 176
d_13	ens_2	THR	THR	THR	THR	Z	X	17 - 191	2 - 176
d_14	ens_2	THR	THR	THR	THR	b	BA	17 - 191	2 - 176

NCS ensembles :

ID
ens_1
ens_2

NCS oper:

ID	Code	Matrix	Vector
1	given	(0.952691406108, -0.202521983741, 0.226636119869), (0.17810068318, -0.232255054224, -0.956210090115), (0.246290948633, 0.951337183069, -0.185198090521)	-22.1540198577, 90.016615621, 114.613896475
2	given	(0.93285609393, 0.0636209987293, 0.35458690971), (-0.103814175021, -0.895052214049, 0.433709754549), (0.344966846352, -0.441399935033, -0.828350150764)	-34.1404942303, -43.786176049, 174.72976777
3	given	(0.984592050774, -0.162734698397, 0.063999308515), (0.151836279105, 0.614054586197, -0.77452095486), (0.0867423650847, 0.772304592184, 0.629302295397)	-6.51540616241, 73.6089693119, 36.4720150495
4	given	(0.929068811798, -0.0962992456312, 0.357152065983), (0.0691546211714, -0.903278247982, -0.423445445238), (0.363385169367, 0.418108672492, -0.832548110725)	-34.5042346136, 38.2018596556, 176.168357273
5	given	(0.987315217743, 0.139393299205, 0.0760142680742), (-0.147180864891, 0.6239512309, 0.767478113348), (0.059552110156, -0.768930666312, 0.636552571734)	-7.25087997491, -74.0714231088, 33.9784934596
6	given	(0.957870328377, 0.167151002827, 0.233548659316), (-0.195568682276, -0.215910040687, 0.95662727582), (0.210326709021, -0.961999686374, -0.174124320209)	-22.4673283057, -93.0639841066, 111.625725466
7	given	(0.999727245031, -0.00624559674559, -0.0225039566193), (0.00606638086207, 0.99994941207, -0.00802323654825), (0.0225529280908, 0.00788453059886, 0.999714559068)	10.2829148418, -3.88767707785, -94.1159349247
8	given	(0.946015035794, -0.224207323093, 0.234065435987), (0.182143403953, -0.229597023178, -0.956090470272), (0.268103212306, 0.947109435715, -0.17636435108)	-14.667871314, 85.3902311599, 19.4603026755
9	given	(0.981316662927, -0.185048009784, 0.0526767608715), (0.157133808084, 0.612832554714, -0.774432196025), (0.111025102648, 0.7682405183, 0.630460095981)	2.69703781954, 68.8908231037, -58.0158000127
10	given	(0.920686686385, -0.102175258638, 0.376691175947), (0.0751898826203, -0.900616314174, -0.42806160327), (0.38299152349, 0.422433984387, -0.821502904298)	-28.1384221459, 34.0676967744, 80.9133556118
11	given	(0.986224358625, 0.15525981267, 0.0570605382476), (-0.143349081947, 0.630085069276, 0.763180087646), (0.0825382042467, -0.760846368227, 0.643661594936)	2.77347151102, -78.2957117852, -60.883396127
12	given	(0.952447137713, 0.194493086604, 0.234556792964), (-0.191272757008, -0.217593667581, 0.957114271263), (0.237190181687, -0.956465072594, -0.170045236978)	-14.2386804721, -97.9242871099, 16.9306844084
13	given	(0.924950712871, 0.0783309832718, 0.371927998164), (-0.0979175204759, -0.89639757526, 0.432300296382), (0.36725786301, -0.436274734689, -0.821453600594)	-27.5358350216, -48.3657537564, 79.8196217183
14	given	(0.957501216617, -0.195574216513, 0.211995627341), (0.166107073037, -0.226972142371, -0.959631224416), (0.235796226568, 0.954062038037, -0.184839841792)	-20.4188435678, 91.0956709493, 114.974364663
15	given	(0.933381065347, 0.0746331928978, 0.351040842879), (-0.0894016834997, -0.898949918904, 0.428831414765), (0.347573194937, -0.431646765098, -0.832390499911)	-33.4778004858, -43.7290538613, 175.248253307
16	given	(0.933402147344, -0.0970989040725, 0.345444979933), (0.0641095724169, -0.902077831343, -0.426785132033), (0.353058626941, 0.420508488652, -0.835776415625)	-33.1976970195, 38.9822237482, 176.93093314
17	given	(0.987624283499, 0.138763861261, 0.0730949071522), (-0.145048246071, 0.630838638405, 0.76223593369), (0.0596597096484, -0.763405005946, 0.643159012952)	-6.8131157072, -73.388945019, 33.4348163908
18	given	(0.987080618875, -0.149239290761, 0.0583051107021), (0.139778870068, 0.62421095808, -0.768649820982), (0.0783180651147, 0.766869163486, 0.637007038242)	-5.65487156309, 73.5307677123, 35.7440849796
19	given	(0.960090005889, 0.170258781265, 0.221898913911), (-0.183074725092, -0.217242882289, 0.958795689981), (0.211449345293, -0.961154242303, -0.177402640562)	-20.9472331527, -93.8123324748, 112.149687518
20	given	(0.999626077379, -0.0073918598938, -0.0263261434894), (0.00726704108451, 0.999961911655, -0.00483377205176), (0.026360871336, 0.00464065142871, 0.999641720226)	10.6925895725, -4.41583301534, -94.2756970329
21	given	(0.948840078619, -0.222037513786, 0.224503558276), (0.172248308076, -0.23192118977, -0.957362565646), (0.264637536211, 0.947054330124, -0.181810533856)	-13.519292164, 85.8717999083, 20.1156834475
22	given	(0.921554027809, -0.103550087669, 0.374186521902), (0.0692988889369, -0.904429584954, -0.420956992877), (0.382015494217, 0.413865322543, -0.826304820859)	-27.8525687844, 33.4239071702, 81.328742585
23	given	(0.986350679237, 0.156205133099, 0.0520796885808), (-0.140314041877, 0.631859745655, 0.762276348494), (0.0861644196942, -0.759179305708, 0.645153062896)	3.41017351356, -78.2904012175, -61.1561061395
24	given	(0.983566435528, -0.174211835881, 0.0474057289983), (0.146518843866, 0.616765765839, -0.773390081706), (0.105495475235, 0.767626358542, 0.632155422643)	3.48783854212, 69.0997821274, -58.0573020089
25	given	(0.955202008684, 0.195382169977, 0.222294692382), (-0.179526573424, -0.214613460649, 0.960057952388), (0.235285639257, -0.956957088987, -0.169922917219)	-12.8389142622, -98.6943786154, 17.0658456196
26	given	(0.923561505931, 0.0899230442544, 0.372757281451), (-0.0847809749246, -0.900167938141, 0.427211738409), (0.37396033353, -0.426159042208, -0.82373669318)	-27.3888660138, -48.2743797941, 79.9617896571

Components

#1: Protein

A O C Q F S H T J V L X E a
ATP-dependent Clp protease proteolytic subunit 2 / Endopeptidase Clp 2

Details:

Mass: 21706.742 Da / Num. of mol.: 14
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Mycobacterium tuberculosis CDC1551 (bacteria)
Strain: CDC 155 / Gene: clpP2
Production host: Escherichia coli 'BL21-Gold(DE3)pLysS AG' (bacteria)
References: UniProt: P9WPC2, endopeptidase Clp

#2: Protein

B P D R I U K W M Y N Z G b
ATP-dependent Clp protease proteolytic subunit 1 / Endopeptidase Clp 1

Details:

Mass: 19296.033 Da / Num. of mol.: 14
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Mycobacterium tuberculosis (bacteria) / Gene: clpP1
Production host: Escherichia coli 'BL21-Gold(DE3)pLysS AG' (bacteria)
References: UniProt: P9WPC4, endopeptidase Clp

#3: Protein/peptide

c e f g h i j k l m n o p q r s t u v ...
4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide

Details:

Mass: 348.437 Da / Num. of mol.: 28 / Source method: obtained synthetically / Source: (synth.) synthetic construct (others)

#4: Chemical

B-201 R-201 F-301 I-201 U-201 V-301 K-201 W-201 M-201 Y-201 N-301 Z-201 G-201 b-201
ChemComp-AI4 / 4-[1-[3-[4-[(4-fluoranyl-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-quinazolin-7-yl]oxypropyl]piperidin-4-yl]benzamide

Details:

Mass: 583.653 Da / Num. of mol.: 14 / Source method: obtained synthetically / Formula: C₃₃H₃₄FN₅O₄ / Feature type: SUBJECT OF INVESTIGATION

• Has ligand of interest: Y

Experimental details

Experiment

• Experiment: Method: X-RAY DIFFRACTION / Number of used crystals: 1

Sample preparation

• Crystal: Density Matthews: 3.08 ų/Da / Density % sol: 60.11 %
• Crystal grow: Temperature: 291 K / Method: vapor diffusion, hanging drop / pH: 6.5 / Details: 1.5M ammonium sulphate and 0.1M Mes

Data collection

• Diffraction: Mean temperature: 100 K / Serial crystal experiment: N
• Diffraction source: Source: SYNCHROTRON / Site: SSRF / Beamline: BL19U1 / Wavelength: 0.979 Å
• Detector: Type: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Apr 10, 2020
• Radiation: Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
• Radiation wavelength: Wavelength: 0.979 Å / Relative weight: 1
• Reflection: Resolution: 3.24→33.31 Å / Num. obs: 110784 / % possible obs: 99.59 % / Redundancy: 2 % / B_iso Wilson estimate: 97.92 Ų / CC_1/2: 0.998 / Net I/σ(I): 9.99
• Reflection shell: Resolution: 3.24→3.356 Å / Num. unique obs: 11044 / CC_1/2: 0.7

Processing

Software

Name	Version	Classification
PHENIX	1.19.2_4158	refinement
PHENIX	1.19.2_4158	refinement
XDS		data reduction
XDS		data scaling
PHENIX		phasing

Refinement

Method to determine structure: MOLECULAR REPLACEMENT
Starting model: 6IW7

6iw7

Resolution: 3.24→33.31 Å / SU ML: 0.4331 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 28.0443
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2

	Rfactor	Num. reflection	% reflection
Rfree	0.2536	5552	5.02 %
Rwork	0.1786	105061	-
obs	0.1824	110613	99.7 %

• Solvent computation: Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
• Displacement parameters: B_iso mean: 95.85 Ų

Refinement step

Cycle: LAST / Resolution: 3.24→33.31 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	39494	0	1302	0	40796

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.0228	41470
X-RAY DIFFRACTION	f_angle_d	2.2698	56144
X-RAY DIFFRACTION	f_chiral_restr	0.097	6364
X-RAY DIFFRACTION	f_plane_restr	0.0151	7214
X-RAY DIFFRACTION	f_dihedral_angle_d	11.3664	6004

Refine LS restraints NCS

Ens-ID	Dom-ID	Asym-ID	Auth asym-ID	Refine-ID	Type	Rms dev position (Å)
ens_1	d_2	A	A	X-RAY DIFFRACTION	Torsion NCS	0.644644921019
ens_1	d_3	A	A	X-RAY DIFFRACTION	Torsion NCS	0.548004342847
ens_1	d_4	A	A	X-RAY DIFFRACTION	Torsion NCS	0.538626883351
ens_1	d_5	A	A	X-RAY DIFFRACTION	Torsion NCS	0.562772594044
ens_1	d_6	A	A	X-RAY DIFFRACTION	Torsion NCS	0.565581632308
ens_1	d_7	A	A	X-RAY DIFFRACTION	Torsion NCS	0.654691205017
ens_1	d_8	A	A	X-RAY DIFFRACTION	Torsion NCS	0.314087133749
ens_1	d_9	A	A	X-RAY DIFFRACTION	Torsion NCS	0.623501476516
ens_1	d_10	A	A	X-RAY DIFFRACTION	Torsion NCS	0.69122741883
ens_1	d_11	A	A	X-RAY DIFFRACTION	Torsion NCS	0.543701378112
ens_1	d_12	A	A	X-RAY DIFFRACTION	Torsion NCS	0.558983765131
ens_1	d_13	A	A	X-RAY DIFFRACTION	Torsion NCS	0.529202067588
ens_1	d_14	A	A	X-RAY DIFFRACTION	Torsion NCS	0.497137374845
ens_2	d_2	C	B	X-RAY DIFFRACTION	Torsion NCS	0.549224786462
ens_2	d_3	C	B	X-RAY DIFFRACTION	Torsion NCS	0.626205762123
ens_2	d_4	C	B	X-RAY DIFFRACTION	Torsion NCS	0.67164209645
ens_2	d_5	C	B	X-RAY DIFFRACTION	Torsion NCS	0.733594728967
ens_2	d_6	C	B	X-RAY DIFFRACTION	Torsion NCS	0.636408136444
ens_2	d_7	C	B	X-RAY DIFFRACTION	Torsion NCS	0.707996427142
ens_2	d_8	C	B	X-RAY DIFFRACTION	Torsion NCS	0.326031927601
ens_2	d_9	C	B	X-RAY DIFFRACTION	Torsion NCS	0.532211284082
ens_2	d_10	C	B	X-RAY DIFFRACTION	Torsion NCS	0.632557762171
ens_2	d_11	C	B	X-RAY DIFFRACTION	Torsion NCS	0.764224463223
ens_2	d_12	C	B	X-RAY DIFFRACTION	Torsion NCS	0.624739063074
ens_2	d_13	C	B	X-RAY DIFFRACTION	Torsion NCS	0.695026174636
ens_2	d_14	C	B	X-RAY DIFFRACTION	Torsion NCS	0.653548904593

LS refinement shell

Resolution (Å)	Rfactor Rfree	Num. reflection Rfree	Rfactor Rwork	Num. reflection Rwork	Refine-ID	% reflection obs (%)
3.24-3.28	0.3244	165	0.2647	3519	X-RAY DIFFRACTION	99.95
3.28-3.32	0.3281	194	0.2511	3488	X-RAY DIFFRACTION	99.95
3.32-3.36	0.3207	160	0.2539	3518	X-RAY DIFFRACTION	100
3.36-3.4	0.3809	193	0.2617	3468	X-RAY DIFFRACTION	99.97
3.4-3.44	0.3098	192	0.2482	3547	X-RAY DIFFRACTION	99.95
3.44-3.49	0.3318	205	0.2471	3449	X-RAY DIFFRACTION	100
3.49-3.54	0.3254	201	0.2357	3518	X-RAY DIFFRACTION	100
3.54-3.59	0.3177	176	0.2167	3458	X-RAY DIFFRACTION	99.97
3.59-3.65	0.291	187	0.2169	3541	X-RAY DIFFRACTION	99.97
3.65-3.71	0.3036	199	0.2003	3472	X-RAY DIFFRACTION	99.97
3.71-3.77	0.2724	162	0.1881	3526	X-RAY DIFFRACTION	100
3.77-3.84	0.2625	175	0.1862	3534	X-RAY DIFFRACTION	99.97
3.84-3.91	0.264	167	0.1921	3482	X-RAY DIFFRACTION	99.81
3.91-3.99	0.243	195	0.1827	3465	X-RAY DIFFRACTION	99.84
3.99-4.08	0.2454	167	0.1682	3525	X-RAY DIFFRACTION	99.97
4.08-4.18	0.2328	205	0.1584	3493	X-RAY DIFFRACTION	99.95
4.18-4.28	0.2438	181	0.1671	3527	X-RAY DIFFRACTION	99.89
4.28-4.4	0.2363	180	0.1582	3472	X-RAY DIFFRACTION	99.7
4.4-4.52	0.2165	188	0.1456	3512	X-RAY DIFFRACTION	99.65
4.52-4.67	0.2051	172	0.1555	3485	X-RAY DIFFRACTION	99.65
4.67-4.84	0.2018	190	0.1426	3526	X-RAY DIFFRACTION	99.89
4.84-5.03	0.2362	178	0.1626	3507	X-RAY DIFFRACTION	99.92
5.03-5.26	0.2843	179	0.1689	3530	X-RAY DIFFRACTION	99.89
5.26-5.53	0.2378	195	0.1778	3517	X-RAY DIFFRACTION	99.81
5.53-5.88	0.2851	185	0.1836	3495	X-RAY DIFFRACTION	99.78
5.88-6.33	0.2803	201	0.1947	3516	X-RAY DIFFRACTION	99.79
6.33-6.96	0.2651	194	0.196	3503	X-RAY DIFFRACTION	99.73
6.96-7.96	0.2357	186	0.17	3533	X-RAY DIFFRACTION	99.89
7.96-9.98	0.2363	188	0.1467	3522	X-RAY DIFFRACTION	99.36
9.98-33.31	0.2145	192	0.1606	3413	X-RAY DIFFRACTION	94.87

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°2)	L12 (°2)	L13 (°2)	L22 (°2)	L23 (°2)	L33 (°2)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å2)	T12 (Å2)	T13 (Å2)	T22 (Å2)	T23 (Å2)	T33 (Å2)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	5.4450686776	-1.4875255688	1.98623941919	1.32499703239	0.0235534349217	1.78150523136	-0.526957302128	-0.486428230732	1.08612167255	-0.341796113127	0.382924519703	0.730383769115	0.16992482185	-0.47112835376	0.357785512702	0.798591367733	0.0865657441909	-0.140036918695	0.966054813038	0.102156117199	1.00937177964	3.212	-18.226	93.4
2	1.40897332754	-1.38800562944	-0.567635153496	3.7911619477	-0.186896535221	4.73058608142	0.172372397497	-0.324946447148	0.495926233463	-0.276989187088	0.0007487805659	-0.0430220605874	0.168374813147	-0.452074887843	-0.105040031862	0.628049983234	-0.00850519264178	0.00909531803397	0.806920911047	0.218916755326	1.13087690189	13.567	-26.082	110.242
3	0.949841073732	-0.215511137536	-0.884440922843	3.31738146944	0.478704729992	1.03598461645	0.00451200836691	0.0263014767508	-0.0975976118431	0.0361146040539	-0.22821019293	-0.195912066712	-0.371800855599	-0.0892008719858	0.0610632956553	0.678990646568	0.0136263073361	-0.141736353992	0.594704942435	0.112790697832	0.80912361475	17.936	-35.355	105.414
4	2.01704835051	2.80413984754	1.5390854468	2.39377434533	2.3004246446	4.28832832387	-0.269296981656	-0.30437600086	0.0965905582488	-0.248885060445	-0.147585548551	0.475473828711	-0.785624709366	0.168968868795	0.340755088015	0.960460625279	0.0356919920146	-0.111819390979	0.726235348078	0.110273108913	0.833920506701	32.481	-29.575	122.323
5	1.99898315923	1.13847943738	0.0872529731687	3.94491435779	-0.999117941907	5.4208118432	0.339392158553	-0.174156990126	-1.14050583482	0.219324848583	0.281473419754	0.287037260797	0.968855118959	0.629247576159	-0.526635025977	0.693613383423	0.115226242912	-0.108558389307	0.61017150158	0.0541120012129	1.01090009895	25.232	-42.433	105.304
6	3.72494765763	-0.30268928136	-0.657583934436	5.34312550307	-3.20752241684	4.35669353721	-0.996801440806	1.43271597719	1.10644394002	1.4182141844	-0.345054740451	-0.338066424748	0.901640229349	0.382454718417	0.253019236412	1.23467555283	0.029708444566	0.000201941161281	0.857031002872	-0.178346512191	0.638932634615	76.78	-3.466	126.596
7	3.8656389652	0.642804396805	-1.77760080779	4.02132460512	0.0872903530107	2.09592758812	0.00350217100536	0.0752331071693	0.0239654596976	0.14992348942	0.0826848573417	-0.610066251474	0.178107038833	0.274519765551	-0.115161093969	0.820853506578	0.109458910429	-0.101366090928	0.941490156504	-0.0950027562005	0.744834317348	70.706	-13.413	130.962
8	2.83523314099	1.99318721741	0.659066255385	3.57482990181	1.79871055477	1.12400413611	0.176072634464	-0.752641965422	-0.303979094898	-0.0425505039512	0.0523023136012	-0.0028433935576	0.0872259546063	0.171727553272	-0.185998793853	0.805329399677	0.184661316357	-0.141890083575	0.9799926153	-0.007883349232	0.662906616309	65.289	-16.282	138.18
9	6.50347587038	3.90974441185	3.90541801813	7.79237511189	4.40473841048	5.16211831744	0.303107220074	-1.27989469561	0.222048892523	0.00614299127715	-1.05681719611	0.323267576516	-0.48315565681	-1.57166803617	0.45539251508	0.721439809922	0.196791067389	0.0643381391923	0.616123780416	0.126832769425	0.499552663931	50.051	-13.824	134.444
10	2.78567032141	0.789255135391	3.17667550866	3.2892827136	0.894174734732	4.62976318379	-0.089774671897	-0.715145247507	-0.36378059537	0.55923845196	-0.0539877086139	-0.278561487097	0.13600654223	0.544826700731	0.208334771059	1.02062122078	0.153401622494	-0.00211424226855	1.05861753151	0.113814618325	0.592499278584	50.017	-27.356	133.814
11	8.50384992881	-1.87557600225	4.13396714486	6.65058275463	0.466471635544	2.73900998952	-0.276999010709	-0.490259654093	0.206321425742	1.93172444971	-1.37654571516	0.207546201428	1.34396970402	-1.40544206176	1.52464933919	1.38161268546	-0.219106133842	-0.32280699913	1.08394510902	0.0184507440327	0.969746047171	48.915	-21.223	147.007
12	4.03798270557	0.16631494997	1.97563107694	2.7923952622	-0.853289567304	4.34866372694	0.691517421517	-0.48111587574	0.129063896266	1.14759126067	-0.40117676478	-0.0214055214382	-0.329588617265	-0.488135200656	-0.289819139421	1.24700285778	0.143995665944	-0.084752324812	1.03366984065	-0.0337180490982	0.634393622488	56.805	-9.594	146.707
13	2.81794984375	0.113177830781	-1.26191145087	3.43480253553	2.64488265818	3.00898070788	0.746066166804	-0.356175142351	-0.0815602069548	-0.276713901409	-0.781279744675	0.616024957034	-0.504864813824	-1.11454235278	0.654726682477	0.74486223031	0.0725120333632	-0.00848063508638	0.876776285791	0.0484360148172	1.18849512868	5.7	5.536	81.199
14	4.88176151688	2.77560875462	-2.1354715217	5.75824168049	0.30124058643	2.9157673442	0.132850060636	-0.167710425905	-0.333452692945	-0.259788006618	0.0490088960938	0.387218082525	0.336346038811	0.136460104454	-0.165175367427	0.609026541706	-0.0308282578698	-0.164774353041	0.697338558283	0.135118111203	0.70337375624	22.765	-3.971	70.135
15	2.10468365021	-1.67401903735	2.35803093622	4.16128841913	-0.845372478461	1.44170439077	0.202589901508	-0.0649508900879	0.206806097935	-0.678474049623	-0.142859500794	-0.138429239154	0.228592147639	0.0672000835153	-0.127116981133	0.856669349248	0.0621387985701	0.0242174853079	0.710131416584	-0.0204927800053	0.720216911655	42.639	-11.728	69.018
16	1.2270172323	-0.0976699229134	0.404848262517	3.19195236233	1.99499640077	2.42585783637	-0.462674693482	0.534343625089	0.803925207963	-0.777297822473	0.45486849404	0.475143463647	-1.37907624597	-0.188577972438	-0.180945836076	1.14611185883	-0.0109807303278	-0.119152274071	0.659758445227	0.194600577963	0.75455415067	28.2	9.506	61.277
17	4.22427037115	-0.779305948464	-1.61758317532	4.15819505369	2.55136703925	8.17921508251	0.815420662322	-0.729416779781	1.91556475915	-0.353248036431	0.413438359438	-0.484251210676	-1.47586478812	0.849551294619	-1.30714219546	1.24257294031	-0.258204006679	-0.0135100859799	0.691394309051	0.269926136593	1.44089453411	80.885	-17.288	105.816
18	2.69531183082	-0.192620464052	0.545843882817	5.59061925483	-1.52317913232	5.12066167464	0.000606253664095	0.503972024859	0.174530780755	0.5533432759	-0.461518195332	0.239370127191	-0.464470559883	0.705415730181	0.557995866041	0.741964199433	-0.0324261141436	-0.105231808917	0.907786555852	-0.114371872188	0.926312844025	77.421	-17.218	94.717
19	2.45270474526	-0.344516674905	-1.21451259121	2.26362292489	-0.791579309898	4.14356231806	0.491235240015	0.329920604821	-0.323492700932	0.68654578519	-0.182755091367	-0.142160889906	-0.557932336013	0.776886273309	-0.479133558067	0.768641521156	0.0116660900011	-0.142491295436	0.728340094156	-0.104785039099	0.809974249163	75.916	-22.67	89.987
20	5.32084808296	-0.314359145573	0.110641067493	3.99557024602	0.341755911487	3.10875718103	0.539232947395	1.14016330134	0.0681386131444	-0.0590184896317	-0.0490381217482	-0.531239340452	0.0895768733866	0.121405406888	-0.647784825825	0.594352390234	0.120125404372	-0.00381395580031	0.684217135348	-0.019549188448	0.928988395937	74.954	-28.596	90.391
21	3.13899331475	-1.82939299528	-0.347680196636	3.76439549737	-2.04757469257	2.91304015254	0.0427646774967	0.0232228100208	-0.708936872261	0.149286295692	0.406416151096	0.295965827394	0.0573817516304	0.201576983353	-0.226077230212	0.56117930045	-0.0611137108327	-0.0340056606405	0.553109610921	-0.263440050214	0.725445847388	62.415	-28.456	90.092
22	4.21505232318	-3.69394862067	1.54589486464	6.43288258	-1.1564976919	2.73977011316	0.496964543942	0.734754461216	-0.413390463072	-0.631221472921	-0.134263972584	-0.66158199242	0.0429860992975	0.623284130956	-0.544664942219	0.72365840168	-0.0214229109798	-0.0828437953041	0.84318888059	-0.325920031456	0.807664885455	61.304	-22.843	76.001
23	3.16289943722	-2.44867414561	-4.00216186417	4.36951316952	0.986018221078	6.92325647343	-0.205098148328	1.18233775442	-0.633377195114	-0.429206974865	0.214909720068	0.761831048077	1.49793888482	0.240075912665	0.337962904347	0.852115839626	-0.0971771758612	-0.135123163492	1.00773623901	-0.288466311902	0.958492829834	59.596	-35.823	80.838
24	5.80670615434	-3.07395309599	-0.227343764095	2.61256796608	2.98053886311	9.33370132011	0.804068602238	-0.0508737809577	-0.901222809198	0.433037075607	-0.383987273681	-2.30002024891	0.691480265356	-1.55381377581	-0.0980361814341	0.958189637742	0.0321630529457	-0.0798855708835	0.489291897376	0.0916238424569	1.48623041269	64.262	-39.524	91.473
25	6.31436189989	0.471190257869	-2.12350183598	4.01610520412	1.84640515532	1.99746333995	0.409527728235	0.833239442586	0.992224694727	0.897891601685	-1.0552953591	-0.334048233087	0.187098184078	0.25820752954	-0.28642836763	0.79567093523	0.075218527343	0.0814092092821	0.783961790186	-0.290256816409	1.00453635701	74.685	-38.848	93.824
26	2.83405830012	0.321896273186	-0.178639239576	6.28690779698	0.46609394669	1.09140991916	0.319571121548	-0.353401336678	-0.302638672986	-0.191585211763	0.10328598963	0.242788400503	-0.126477503948	-0.205281796803	-0.395226086596	0.546721667311	0.01530535874	-0.0492263333438	0.69133548017	0.12765584836	0.845412341091	14.178	-20.604	85.203
27	1.34559533988	-0.129531001091	-1.99529665348	2.93782138628	0.0912608818835	2.39007185915	0.0228827240369	-0.272028670828	0.273366787143	-0.264984798249	0.148637211429	0.0641316320685	0.451217640084	-0.225731208507	-0.0920209303387	0.6874119502	-0.0298761291475	-0.2180678034	0.694326604655	-0.0308765479182	0.896494326786	23.631	-27.093	77.026
28	1.62114519585	1.30083916194	3.55949978791	3.26146083904	-1.46985549799	6.02977588148	-0.273643721869	-0.25960821579	0.530025974416	0.00633360351611	-0.0573327137001	-0.081630355336	-0.189004273182	-0.680089575515	0.401371697017	0.780017792205	0.0568312758535	-0.147398379151	0.774379407324	-0.015180987425	0.810355373849	38.079	-34.386	93.392
29	2.93655549246	-0.714486934665	-0.0259312658747	3.64876634785	1.36255018194	2.25884036123	0.606447377163	0.277102080292	-0.419686754349	-0.742015682405	-0.299991530099	-0.00904031401511	0.326289580295	0.501431262798	-0.307705690899	0.78255284351	0.0826211385207	-0.0940836496591	0.646040817719	-0.0389016360104	0.675248620031	31.374	-29.27	71.446
30	6.40988560787	1.83253829683	-2.03464676837	2.98791468991	-0.611105832994	3.6561503847	-0.64238438406	-1.24133268827	1.29729827542	0.299425988656	0.563521597469	0.556095465718	1.09473968438	-1.31144982544	0.0677779145952	0.726366300169	0.0567331622303	0.0358006691374	1.26337265618	-0.0813914076592	1.06027081832	3.557	15.298	91.884
31	6.97906327818	-0.0813791616643	2.38658796677	4.04607898891	2.04237565876	5.54476635095	-0.245203480211	-0.463046837501	-1.00653232719	0.167949624464	0.692704891539	-0.461633059494	-0.348009272466	0.156812432669	-0.550210154052	0.761639178893	0.0147141388529	-0.102678055193	0.686062685291	0.05716115039	0.979743546787	18.629	13.224	80.693
32	3.03872707085	1.2801827857	0.0977687610952	1.84567530263	0.429934207898	4.69749132148	0.20390613909	0.93666304511	0.407553985129	0.216417906894	-0.171702178694	0.460391630781	-0.395540505695	0.37425395108	-0.0850684029113	0.792518086473	0.0953733714745	-0.161139505897	0.608858292576	0.233041595119	1.02114648283	16.979	20.897	79.93
33	2.82098927174	-0.0642561761081	0.285172801387	4.04962674828	-0.393567956813	3.14482455163	-0.0069497426576	-0.0390041422894	-0.311553689594	-0.464647088138	-0.0374799153392	0.582808525404	-0.297546986117	0.289078991052	-0.0297398299721	0.613220798254	-0.00557172890073	-0.177564384646	0.542635196635	0.126366300931	0.829304413301	23.978	23.509	78.014
34	2.71861267449	-4.40355694164	0.516936022351	5.51639281914	-0.219608816985	0.885420307941	-0.295850397202	0.0807622210072	-0.192654245766	-0.10902905679	0.318677771108	0.373953442028	-0.266463653679	0.100023057894	0.00471022856364	0.776698592642	-0.0418039876068	0.010002624586	0.673620938323	0.00776465781781	0.74059000205	42.198	15.42	73.753
35	4.38238166311	-1.93864664214	-1.38947762757	4.49704357628	-1.37290625746	3.57010126489	0.605852167308	-0.235104823932	0.877281290299	-0.356106387576	-0.12533943874	-0.111225028736	-0.552094119997	0.196263767317	-0.507765997971	0.803424582508	-0.0527070755699	-0.0625188184775	0.465992871074	-0.0746496519434	0.86337315143	29.834	33.866	80.591
36	2.17955568782	0.434735422802	0.181128635309	2.21761943655	-0.411108292345	4.45499883755	-0.109612989408	0.149254512568	0.276892500911	0.374834712558	0.0189469388787	-0.291492431905	0.00991755926296	0.0507619585535	0.0603952416963	0.63243879391	0.0321520720082	0.0577573385242	0.722302290178	-0.1597265248	0.789186216566	77.975	-2.221	83.124
37	2.96620992271	-2.30544831607	-0.243703608994	4.01613532705	0.0773592642116	1.18120323182	0.221758598195	0.201787192959	0.202393391286	-0.54621262001	0.0513598466477	-0.0551734715541	-0.0801151161981	0.253010874916	-0.297269833636	0.763709114193	-0.0829628902916	0.0524762517762	0.788482163393	-0.040843050282	0.589708121714	64.647	0.61	70.259
38	1.80063507033	0.603566232404	0.977458033342	3.38129020443	1.50022838165	6.16672633222	0.0241494738537	0.580859756903	-0.0329634270513	-0.0792985519259	-0.146711285072	0.00046128201629	1.36014845388	-0.71199263592	-0.0638736588752	0.730782338646	0.0581235670977	0.0444840867159	0.87019988564	0.0498242202285	1.11085595849	1.63	-14.264	107.167
39	4.12697690838	0.916023698544	1.35605144773	3.53818608944	0.0203211716399	4.23565410633	0.0144177403706	-0.322101733203	0.414644697798	-0.143321085697	-0.271335414781	0.362982552027	0.0495749227481	-0.259424412233	0.19309763574	0.733019209971	0.113586009412	0.188270644556	1.16651170502	0.106272586581	0.786916305181	10.617	-6.333	121.455
40	3.15313970145	-0.805459313838	1.69158469971	4.15212848382	-0.463618499861	2.98469429772	0.0966644200971	-0.164964452314	0.356597249044	0.3083418603	0.121647128732	0.337041921812	0.0794865684772	-0.256844007842	-0.147620476759	0.681452508371	0.0527316925192	0.0830206119171	1.18129497768	0.308718407856	0.830601499067	12.369	-13.764	128.746
41	2.69865550742	3.02381671629	-1.27869824786	2.9895369263	1.31443528311	2.99939198632	-0.324715715663	0.163829962491	0.167956443389	-0.344143146137	0.619950318761	0.040374941972	-0.18241173464	-0.0524571932368	-0.286764429726	0.859872775071	0.12839455742	0.0123772885549	1.0374688642	0.0688803540502	0.614716090986	30.058	-3.466	136.506
42	5.47683026914	2.86885542097	1.7187459927	4.94290130226	-0.258780689943	2.0771035304	1.11868233224	-0.311540425059	-0.421826146429	1.42035579035	-0.839447816043	-0.489367688296	0.555192537891	0.390548454182	-0.28065627121	1.03267221571	-0.00530098352762	-0.123320102257	1.12461346226	0.28051484804	0.715172931885	24.34	-21.075	138.642
43	7.11384687879	0.757433056359	0.0900114011629	6.54825293092	1.2140622594	5.74379829272	-0.671701674595	-0.984401289883	-0.668948025337	-0.20474394481	0.0932617135261	0.187403424857	1.01287931066	-0.323365576231	0.36554514057	0.749626893552	-0.0507129876417	0.164397890434	0.888167029343	0.260249963072	0.918125436875	9.977	-28.324	127.718
44	1.25951290501	0.113482105381	-1.26633513718	2.63820019083	-0.836735553369	4.87411879109	0.0133039592511	0.616234678591	0.488670349044	-0.0833622554436	0.0505400301033	-0.80464612475	-0.299965806225	-0.37568385392	-0.0708928224956	0.904768113311	0.125670480624	-0.0958164609908	0.682976693493	-0.140129038866	1.04417924455	73.137	9.928	126.158
45	4.74780108562	-2.06437210057	4.71405287825	7.62201116638	-1.1519019318	4.86421624525	1.04209172053	2.66328041238	-1.08329729586	0.410075045487	-0.48513778849	0.591460577594	1.27511431324	3.40296409109	-0.366918984142	0.820232210469	0.0467836701018	0.0441650719435	1.44427457046	-0.108582033064	0.688660220789	71.715	2.245	132.183
46	2.02089329637	-0.244540350592	1.0756671808	2.0771047399	-0.66022535364	1.36164074878	0.645806415113	-0.528097746551	-0.081986583327	0.263615752094	-0.616851936552	-0.200241457904	0.251042502805	0.0562531937589	0.0319971160634	1.18224399449	0.119964420499	-0.244316483717	1.05102346949	-0.204167328901	0.747107550414	68.569	9.398	137.585
47	2.73325050767	0.919561751708	1.84497373705	1.83876948636	0.22801380739	2.29532386583	-0.386411766884	-0.260864454361	0.0374852915519	0.369955224291	0.212330799651	-0.676341195351	-0.222300416984	-0.490721813137	0.190848841784	0.931172323853	0.0200568571509	-0.22571292998	0.965545635692	-0.116777643283	0.710776333811	62.351	18.557	136.427
48	2.95298002766	0.952132818844	-0.24288226839	1.72255795441	-0.318209071398	2.67629920668	0.557888915652	0.39942660723	-0.394807289187	-0.690105514177	-0.695812427156	0.143951623749	-0.521177096352	0.0350517857123	-0.128542553785	0.988714985974	0.398572921194	0.0656159802221	0.892610628899	-0.129625122359	0.669116096523	43.848	3.972	133.907
49	5.05384032456	3.29476816249	1.01339378419	5.520877457	0.366541442539	1.81608643401	0.403352296581	-0.877614971136	0.00594811037407	0.545272313118	-0.272040475913	-0.618993698479	0.144693846189	-0.448312009915	-0.308583759401	1.13862074536	0.176814200218	-0.060651777332	0.957033965402	-0.0751472174353	0.536819240829	48.647	4.106	143.287
50	7.86591730576	0.369677385085	4.46150083311	1.76934210469	2.04230012799	5.72330785871	-0.12407457895	-0.679919824646	0.549248918958	0.321286587832	0.641049598609	-0.541794354837	1.4868822327	-0.180171249593	-0.185187516258	1.15135970141	-0.291051921761	0.104042207227	1.52738460456	-0.338103351886	0.920615750702	49.536	18.311	147.709
51	1.77316883766	0.713861775686	-0.10773360268	3.08292775795	-1.28476996867	2.24456084598	-0.182823560882	-0.795238027598	0.286791396151	0.507176832471	0.32208970185	-0.313990035961	-0.47130362851	-0.117590638976	-0.252115276053	1.1389142524	0.171017015503	-0.220594359479	1.24191983465	-0.263089617675	0.665445175317	57.217	23.695	138.743
52	7.198288029	-0.613840856649	1.84657979162	2.28542710985	1.01603668588	0.906085992113	-0.74730982785	0.240452214734	-0.763542496107	0.284741840501	0.205719552314	0.979572271912	0.0321483364591	-0.771459674789	0.660946438399	0.80015845985	0.10519283504	0.105519208603	0.999643956102	0.236499661323	0.973095762032	-0.697	-0.739	113.005
53	1.53069629024	-0.427666891274	1.89489299667	3.56147994318	0.279943603962	4.45291927305	-0.0812872629633	0.0304673359877	0.466456049164	-0.152303899121	-0.381389914975	0.258009374231	0.557137916631	0.570723201625	0.287283488623	0.746082539385	0.295479552793	0.0608274339299	1.26336448244	0.0198680192242	0.770416817169	10.04	12.823	119.68
54	1.40056905208	0.327825356395	1.69911429725	4.97149429609	-0.423096472563	5.07541713681	-0.140608651086	-0.303443495317	-0.0641159171487	1.05568447243	0.110849268866	0.295272039062	-0.690713360281	-0.270855704424	-0.0803860875687	0.618153530883	0.212296753007	0.066088331599	1.20149706632	-0.113993421346	0.707419400079	14.261	14.858	128.526
55	3.48772953749	2.57968370786	-3.38464629224	4.27410836554	0.0915340324504	2.26607895161	-0.0792034648692	-0.0327529978157	-0.333214937224	-0.000243448141902	-0.125587846411	-0.12507930839	-0.301632308856	-0.370925543591	0.306602370011	0.993427538199	0.229544239275	-0.0774376513491	1.01550462011	-0.0343389628791	0.751137723324	32.321	23.98	125.69
56	4.38838402803	2.01008782361	-0.769383857859	3.53120650242	-0.596813940305	3.82868051248	1.05441021864	0.340264635462	0.37145123775	0.570923280876	-0.626500807422	0.540843495956	-1.03262564345	-0.634077243728	-0.462644637495	1.05679002941	0.107974478634	0.116290149392	1.15864088886	-0.104498095308	0.729494783836	19.848	12.681	139.44
57	5.49451936183	-1.40953571083	2.73431039004	1.92720737188	-1.16425331594	7.0642902847	-0.100359308267	0.163397003275	1.44773773114	-0.234173301821	-0.362445156274	-1.52907069945	0.537491641592	-0.550661042969	0.6874031645	0.940790661046	0.199433905157	0.0224412497661	0.767904519632	0.0381546013893	0.856457639252	77.802	-15.423	119.293
58	4.07558429338	1.32733413207	0.560743157535	2.97147741571	0.642397681271	5.32885183633	0.643892447816	-0.274565875123	0.299576984756	0.0314004289422	0.363182644678	-0.485308346436	0.471642241688	0.0605128345736	-0.723594740407	0.714389898847	0.144984094513	-0.14524133928	0.691431840149	-0.211975577345	0.971913125247	74.005	-24.095	112.463
59	0.519164558066	-0.909519107429	-1.17742176479	4.1467616306	1.52546749781	1.42207918063	0.21373586099	-0.239050381721	0.042229388721	0.279791694386	0.174292043176	-0.723336580082	0.00228203091987	0.324073910438	-0.493445629134	0.682606917972	0.0549755337077	-0.117390423689	0.924271956711	-0.0578895752	0.985767690379	71.523	-30.937	113.367
60	3.56793801648	0.507007504682	0.7336377727	4.27492233989	0.963074239171	6.17452286768	0.677771866695	0.0575817344692	-0.252693648341	0.187295551211	-0.931029322139	-1.08744162715	0.113203707707	0.00383916568994	0.192260019643	0.784103485586	0.0121704595467	-0.162672234255	0.698490366585	0.0957146889239	0.878254855934	68.177	-32.389	118.49
61	4.79661422572	-1.99984567987	-1.44568530295	2.35335472313	-1.74875172229	3.9995260724	0.0182848593343	0.693323159506	0.652058674409	-0.589415876336	-0.0358601569553	-0.204509397996	0.475852654459	1.00708602959	0.232249048841	0.870839258578	0.205355533457	-0.262450981088	0.924915726282	0.0187199705264	0.940088387839	71.547	-37.227	123.057
62	3.6521532982	-0.48549970787	2.77605904765	0.796823736261	1.40714928713	6.14285170879	0.547221563852	-0.517725731701	-1.05273866986	0.166522586768	0.619160396088	-0.213630353001	0.302673568464	-0.698281101283	-0.941163004515	0.670181014172	0.0758290096935	-0.0719813679356	0.55162824394	0.111055484838	0.929651607314	53.685	-31.465	114.685
63	3.04259370811	-1.56665467305	0.776509591299	3.79623415495	-0.712922357575	3.90334393588	0.277714885014	-0.0119269918407	-0.398717997301	-0.801749209105	-0.423065161351	-0.156988505292	0.320499497553	0.118027622049	0.0758919149945	0.780001415753	0.164394122014	-0.137423109387	0.632379256961	-0.0398910421551	0.933447198739	55.537	-39.425	103.904
64	3.40277656086	2.05641300232	-0.876687630753	3.84024126643	2.88684364955	4.89591085255	-1.4076331487	0.265036027742	-1.42806627645	1.09330323437	2.14010269962	-0.388342388551	0.0359678034843	0.29635979982	-0.475955273758	0.9734694605	0.160814055724	-0.234153487018	0.808123297757	-0.00672974928659	0.862163970113	54.425	-45.827	117.067
65	4.6091281282	-3.26346350388	1.46828225821	4.34499537054	-1.47119470872	3.02348476704	0.37582618434	-0.569827015289	-1.0052983684	0.79662724419	-0.359493696238	0.0574408211109	0.0705612182659	-0.246910217795	-0.039759870412	0.903155765463	0.0154256666006	-0.0853763335711	0.846069040671	0.122264876001	0.940064334562	54.962	-37.581	124.423
66	2.29890688956	-1.23799900029	-0.231229754799	2.8800657529	-2.66347155041	3.83014567046	0.911767833823	0.463632114752	0.0810491162016	-0.776070634965	-0.516423994538	0.812012346706	0.0473558604904	1.15895863951	-0.954157370797	0.946391156066	0.0175625590776	-0.175859631925	0.696698421727	0.0215252391694	0.750549740349	67.993	-37.579	128.366
67	5.69555067347	-3.39093282627	-5.76430590741	9.83595535675	3.6085278379	5.83566199516	-0.88257700563	2.0011864816	-1.49033705318	1.64033626723	-0.947086205355	0.655638618357	1.96546824812	-0.748969367371	2.42095500116	1.19423163765	-0.130099631632	-0.102455273428	0.87095873301	-0.175809383927	1.32695504731	79.758	14.063	109.339
68	3.86294821216	-1.3951620182	0.217311022898	3.39822123232	0.500324186832	3.86506976599	-0.248764221429	-0.735547395181	0.457644968699	-0.390696688195	0.0757806981616	-0.00801542709486	-0.193018373139	0.57815692487	0.187616425491	0.65015589543	0.0337420149238	-0.0937741446399	0.697634114233	-0.125394751517	0.826758585656	73.664	21.908	116.962
69	1.31561500139	0.538887245404	-0.0127452949667	1.82744304816	-1.25745402268	1.65357561978	-0.614953049604	0.010212642567	0.533197077277	0.352531609614	0.138300172131	-0.0895210990375	-0.562076169706	-0.308481881164	0.460573686498	0.871008849048	-0.00371478874324	-0.222299191103	0.744704318801	-0.292842828857	0.95277355132	68.459	28.502	118.125
70	4.53340719689	1.10890725439	-1.31763599945	4.54987879688	1.24244462947	3.49919112791	0.168024875884	-0.558586078052	0.313750073666	-0.678014354782	-0.57920590491	-0.19202556743	-0.839002468802	0.213149817671	0.434990374461	0.788889743452	-0.0962443976077	-0.0386561743768	0.717656876635	-0.0522413416188	0.950021135378	69.239	35.202	109.775
71	7.35446935555	2.55539559034	-2.40014121427	5.24256090389	-1.8337553506	5.3429851925	0.596152199184	0.61284724479	1.22948205005	-0.908886973486	-0.284914560581	0.716193081323	0.150688279021	-1.34989857181	0.155407632696	1.15906572995	0.374264200385	-0.202860739823	0.842077509525	-0.0565124815127	0.683851700255	46.665	24.621	119.161
72	6.34161321041	2.69114665957	-1.91666055812	4.17341359278	-2.5218848705	2.37068303871	0.191690154334	-1.07091561376	-0.00976982964208	0.722628344756	-0.165991094175	-0.908471804368	-0.576993834261	0.571009859832	-0.0681444987176	0.903257412574	0.0151138938996	-0.187265668423	0.94431339578	-0.362074887134	0.948033235862	52.154	31.302	125.234
73	2.72303086973	0.695568543824	2.42105709264	5.00613999412	-3.53200134901	6.86054703809	0.0403056625742	-0.302559316125	0.78470734005	0.454656290962	-0.774669875963	-0.0827079949451	-1.32536083088	-1.91050671492	0.668244497254	0.657167584795	0.0956679306689	-0.119138552298	1.20265874324	-0.423451726942	1.17148669786	53.464	40.813	115.149
74	4.07211604135	4.1232161708	1.19504966356	4.21651875281	1.26268774671	2.26007529836	-0.17087126455	-0.101994226529	0.385098489005	-1.57903900908	0.0167490797752	-1.05564754493	0.00839259492179	-0.215463830942	-0.249418367295	1.19390518489	-0.157052753577	-0.0470939317845	0.575322835153	-0.255041060708	1.17264710072	61.799	39.609	106.394
75	4.69813495882	1.89565738017	2.69031732769	5.08853161349	-0.506744756629	2.28477698033	-0.0509851069231	0.177731959389	0.595228928894	-1.09248313572	-1.90981117979	-0.206232708414	-1.34306237834	2.66455796502	-0.0794418992087	0.621501975581	-0.240642769117	-0.692219218371	-0.3688574374	-1.43689438728	1.35473488709	72.319	39.022	108.311
76	8.0534573881	2.41556457522	0.668305805234	1.88584261159	0.531228255948	2.90770488808	-0.239399431295	0.702036961619	3.00876618094	-0.976210514102	0.179606944524	0.230375900321	0.528517725595	-0.275467624389	0.361262995279	0.955218874897	-0.0734187645393	-0.0238075996873	1.24466357699	0.210873771259	1.12048040996	-2.235	10.208	108.082
77	1.15994331278	0.267338089193	1.15500953168	5.93452372373	-0.0379927333356	4.28883361799	0.0408744105951	0.236627896729	0.0450797571562	0.381392606613	0.282444421495	0.184146594945	-0.0138085018843	-0.223390322407	-0.317408395613	0.692849892705	0.14897457015	-0.0205520372617	0.991742953206	0.0304464659922	0.994563097774	11.165	21.617	101.93
78	1.7868446475	0.958129915467	-0.704199298165	3.5411094415	1.23954968792	2.80722417633	-0.364196138099	0.0607745322902	0.594089878519	0.258585198981	0.112807280699	0.210336534715	-0.204023652811	0.0695647065976	-0.00240105569908	0.653369282909	0.0949826499191	0.0372756779733	0.911286461637	-0.0149194934366	0.971651629923	18.71	31.485	105.38
79	2.1356022956	-1.16255232412	-2.06250313252	1.08289706063	0.845591867356	4.46215501127	0.0660503653861	-0.179136116169	-0.485313533808	-0.238753554656	-0.176125239376	0.205319458729	-0.588430297558	-0.0983150040872	0.0893236754967	0.871511814735	0.0856604954619	0.00173538422317	0.729584865688	-0.0570498131934	0.937400106358	37.694	32.422	97.689
80	6.06614097584	-0.091279904962	-2.20411442952	3.93364270851	-0.516137097007	3.31640668695	0.0708288169743	-0.943515175013	1.06257072243	0.193811185659	0.351536301802	-0.143287225581	-0.218943159712	0.457566655029	-0.376620836632	0.925726323093	0.129720303638	-0.169732648598	0.884870259647	-0.211621633013	0.966781613595	24.759	37.601	114.511
81	2.49089070527	-1.4103623672	2.27923425045	6.89263172196	-6.07961661931	5.89651491906	0.332229972674	0.521011743743	1.076076612	0.538228348847	-1.59527210662	0.318504561708	1.19515940655	1.25372698609	0.730939072184	1.43913041715	-0.299200727836	0.117514918627	1.22465681455	-0.693934852869	1.04567863866	81.909	7.054	98.209
82	2.69762281749	-2.06247662231	0.0611141372008	4.54315936814	-0.632580474623	4.53347504629	0.110871730475	-0.743340199926	0.0790037974782	0.218954477831	0.0500845508462	-0.303423125246	0.524345901998	-0.167626304009	-0.094285677039	0.727861837723	0.0185165750218	-0.082164186037	0.95594355198	-0.17474721373	0.955688403378	76.843	17.474	98.972
83	1.08889312243	-0.631230182925	0.555214740877	2.85547115932	-0.146832745318	2.66717297252	-0.158319424822	0.122690006892	0.70922083525	0.156809605921	-0.0944030093529	-0.679978762346	-0.211163564745	0.175920529591	0.210872340948	0.635739748238	-0.141095132099	-0.021990706125	0.721282903318	-0.0541676274472	1.09056931604	75.063	22.729	91.965
84	1.72067660065	-0.397547851329	0.0977624577833	2.04169104353	0.33365412304	2.09296759501	0.392684604234	-0.143225043926	-0.391604020267	-0.74039469559	0.554939665307	-0.40116829658	-0.360895386059	0.444494814971	-0.644280951792	0.714538133804	-0.188105180883	-0.00325917687968	0.917965381879	0.0434238100544	0.986945234307	74.61	21.842	81.572
85	3.14489828159	0.488197486686	0.286296534114	1.83829088876	-0.655279181761	2.81907081996	0.570866897101	-0.60680008197	-0.301783585101	0.0263986488332	-0.715455521666	-0.403672189095	-0.195830175372	-0.0421382076361	0.183277963141	0.670226147446	-0.106465736182	-0.0696999914167	0.570523615483	-0.0263313728973	0.761092032593	56.457	31.846	93.307
86	4.69600416458	3.50508863645	3.37993094274	3.98340653081	0.0847323760723	6.81754074396	-1.29029228983	1.29839905851	0.581673444808	0.77478635699	0.753829726003	1.18958772849	-1.1256591755	0.371604511243	0.819033629169	0.889280977538	-0.0902665776435	0.0567296805332	0.818705568572	-0.0639605412224	1.15903302601	62.216	33.991	78.942
87	5.25309851774	-1.9010117808	-1.29910839745	3.7784278843	1.26784228063	1.55055405987	0.621246022796	0.343169398458	0.292112265287	-0.22752260333	-0.690677785706	0.0539588687023	-0.320264216008	0.352184488629	0.13596636784	0.804913555982	-0.114680265321	0.0882776842734	0.620115227349	0.104551751383	0.909578633278	69.353	23.174	77.001
88	7.96539881798	-1.58683853368	2.77626604735	1.67197372209	-0.444602196516	2.77633537164	-0.611013979975	1.62852368815	1.00705714183	0.317965431885	0.469987702673	0.518934590999	-0.847741207134	-0.15645117586	0.597930105689	1.00418362955	0.014681077299	-0.0506158417397	1.0432968983	0.210589697956	1.40974182391	11.475	-22.825	-0.722
89	1.24762511795	-1.15887887427	-0.360644257267	1.59410700035	-0.339970834366	2.25057462209	0.170851212917	-0.295428822139	0.858385860858	-0.221081840464	0.0163601881506	0.0921275506877	0.0378829421513	-0.0253717699095	-0.194284687138	0.88099763862	0.0271096250405	0.0292301029772	0.907655774321	-0.0137873722605	1.26740479694	20.482	-29.778	13.759
90	1.45578986623	-0.961569471914	-1.06117414822	2.59966005331	0.789694108097	3.76319118189	-0.160779856762	-0.250242060573	-0.403358522745	0.126119124185	-0.478592680971	0.32093538634	0.0918139567953	0.453369068871	0.658895786488	0.964301568452	-0.00993268880009	0.0637461040964	0.743091930604	0.174722379612	1.22717755802	24.683	-35.905	17.529
91	1.38459543776	0.0914472124973	0.58806376235	2.31561856587	-0.429851728665	4.14951542571	0.176402052826	0.20020647109	1.51568376353	-0.768439863649	-0.183291239638	-0.369041510894	0.596598320326	0.137778596134	0.0380529374332	0.891956116773	0.0268735826228	0.105754353544	0.492374459672	-0.00345917433787	1.22654235662	27.769	-42.611	9.074
92	3.00685187975	4.41048411794	1.60503400849	3.7445428741	2.8268487018	1.21554583707	-0.260965689336	-0.208036853169	0.214660118468	-0.368569389706	-0.123823921126	0.614607191303	-0.24808776035	-0.069624100751	0.302440813445	1.02376418205	0.0568989769426	0.113346840814	0.831095374873	0.0251292076089	0.971875975845	40.175	-34.284	28.674
93	1.71333083996	-1.02892339899	1.07532947562	3.3433480095	-1.09041843904	4.81314464076	-0.208602921707	0.195740598368	-0.0112139493025	-0.437447178173	-0.392678705137	0.0856441402119	0.371712652749	0.117871683319	0.860160084995	1.22110818299	0.130666217284	0.0137134140498	0.621592824609	0.0176032630532	1.11157919449	37.704	-47.597	15.806
94	1.84858330308	-0.46728980168	0.558309557553	2.21292287653	-2.35895929645	2.39619262141	-0.0206945029544	0.21855332785	0.627886622588	-0.137552911095	0.217658084597	1.51181613493	-0.344620569032	-1.02151757868	-0.490176245121	1.18457899494	-0.171029012764	0.0500728091112	0.603523029667	0.103116981353	1.40303309546	24.132	-45.798	1.671
95	2.09225482916	0.933040960527	1.77695513764	2.02503957601	-2.86439417616	9.86715506668	0.120483313298	-1.14036711631	1.70829014168	-0.943672976505	-1.09031929841	-0.582193676864	0.788452282162	0.808924574078	0.0422886646228	1.26537841871	0.168463332855	0.248780265491	0.928018353106	-0.0672219663898	1.04429235577	84.154	-7.92	34.206
96	4.34774174641	-1.2647686195	-3.02411732176	8.71876863705	-0.954848056444	4.4411197946	-0.907137001728	0.291394234689	0.114170395569	-0.30041223023	0.866710292858	-0.181205629592	0.140662963818	-0.401839786253	0.270928077114	1.10818853577	0.240642951418	0.232723869562	0.763661460016	0.0710567000485	0.539222110388	75.894	-14.32	38.192
97	7.58214339569	-1.21512935064	1.83817924411	5.00434088035	-0.965414453746	7.43475862397	-0.156482210949	-0.134104543796	0.494028147952	-1.17342806325	-0.48396369267	-0.989053727454	1.27457039119	-0.725589036531	0.725817364478	1.09980986673	0.172845105792	-0.0655135862072	0.645538232169	-0.193360974318	0.946294513148	79.982	-21.106	34.516
98	1.84928647532	-0.920906175578	1.46208168393	3.11964271137	-0.174865181283	1.15272501867	-0.00440165033497	-0.162924283833	-0.474184027911	-0.0754591183901	0.442038010494	-0.414610432669	-0.196737267133	0.452611864264	-0.411121885916	0.958894909	0.264621894957	0.151614831565	0.825402935853	-0.123004712163	0.667781114818	75.906	-21.423	42.941
99	3.08908515528	-0.69081658435	1.46152129487	3.63104870212	1.08482765135	2.10589983079	0.285161458879	0.00599750981799	0.215010374315	0.176302020994	-0.0672878559776	0.223801982467	0.525633086652	0.387430748409	-0.0968914104859	0.907765219841	0.162632266878	0.0833697686275	0.838682807176	-0.179595685126	0.711429923375	70.024	-17.519	48.114
100	3.78193969306	2.44568726767	3.21972569541	3.84231852836	3.62746346318	3.56651251402	-0.361548754358	-0.346127428738	-0.104534568381	-1.09676096215	0.140603387062	-0.0807431371469	-1.41391824595	-0.349824183599	0.555211896113	1.07454379145	0.172227897101	0.122601398622	0.74810971465	0.114206208695	0.673864122316	57.271	-18.555	41.373
101	4.22838522873	1.77854750295	5.85650040435	2.87649313829	2.35656267806	7.69983078442	0.054296823582	0.444525506385	-0.250773906932	0.512918283083	0.290789328824	0.00639909187545	0.540664157866	1.1115016981	-0.620279224881	0.993742192059	0.251335051148	0.17349445676	1.01278985188	0.0320659699661	0.716531538231	57.397	-32.061	40.674
102	5.15061199245	-2.70957411248	4.90382470535	4.03817649225	-2.24107755714	4.94335781698	-1.18472469636	0.354912871971	-1.72638468819	0.62961510825	0.564325157784	0.366926222679	0.0672801775224	-0.954540074443	0.201785159547	1.23827866954	-0.326528734161	0.216722918124	0.994752631803	-0.0175561805896	0.831413787272	55.9	-25.932	53.92
103	2.53943424782	2.47630185016	1.45182316174	7.18225120839	2.58080929716	5.39458165112	-1.04122834398	-1.67195941457	0.563377607881	1.15940796753	0.556879862984	1.6953650473	0.316618138427	0.697768904079	0.42175872676	0.833219157301	0.174797450626	0.132811885478	0.824114307411	0.00626595138291	0.953120257197	58.354	-15.318	52.736
104	8.38382363369	-2.40516818299	1.67145847872	6.14179169352	0.732182868589	9.26972848832	1.02120634459	-0.765909635073	0.244984362295	-0.816839541894	-1.08486352258	-1.62388015361	0.774637479393	0.361489021696	0.11936750989	0.977809704923	0.387851834386	0.133346947316	0.827001046478	0.0213202758281	0.662474385667	72.657	-12.6	55.849
105	2.6316643904	-1.74646187798	-1.35835113239	1.29651136336	1.44221798228	1.58359566009	-0.145348944751	0.0181584644444	0.927998242986	0.6199246021	-0.145351737156	0.374270519452	-0.377879479654	-0.591262668203	0.71511049149	1.36548061224	0.00962470700061	-0.139002982234	0.834234593348	0.0223338213025	1.17361860843	14.171	0.937	-12.949
106	2.73372948726	2.65670176367	-1.49588135363	4.88041400291	0.978535700314	1.86778035018	0.218820870913	0.0293557119086	-0.151476278025	0.010644387798	0.0440615137675	0.319407870296	0.518225241373	-0.104349118292	-0.217865039587	1.09496582025	-0.108672470422	-0.164904030302	1.0377678849	0.139404332417	0.860154601131	31.546	-8.566	-23.619
107	2.35522281583	-3.22480846596	0.773688690824	3.65431433178	-2.51595485512	0.741622524484	0.214358520729	0.157134193784	0.190614651731	-0.769913617954	0.128596021833	-0.333323345948	0.941579044089	-0.281175927164	-0.441068957815	1.31588205469	-0.104721518441	-0.00190592067675	0.826487165555	-0.0549316577556	0.67678721913	51.596	-16.334	-24.211
108	1.97600386012	-1.95527251286	1.06710615391	1.98803386802	2.07057341305	2.8455823513	0.743969264321	0.676728680415	0.696203960656	-0.926972266132	-0.707220101304	-0.236833333088	-0.613860599291	-0.296660904975	0.0528191810485	1.31685846737	-0.116711672226	-0.0291808878625	1.03950198678	0.234751835164	0.765856982283	37.17	4.873	-32.417
109	5.01584245465	-0.856439716539	-2.97215364058	3.51586180423	0.0764216545362	5.08262911231	0.386116866469	-1.1041121134	0.638323907703	0.327734812388	0.733902789446	0.472390134712	-0.91864608221	1.21479845783	-1.49511562439	1.11485014228	0.279775496171	0.311427179119	1.44534695682	0.062154267378	1.2051599461	88.886	-21.609	13.627
110	3.31449409087	2.22136809485	-1.55096900355	3.52177719265	-0.155349237806	3.91077204256	0.115630102466	-1.28103994683	0.428382077137	0.578858126101	-0.122285472396	0.0380233571812	-0.639211773314	0.259437923132	0.193705954279	1.10404853218	-0.00310494743916	0.0602963926726	0.97919345594	-0.10679868213	0.706213692509	85.665	-21.665	2.382
111	3.3515223568	-0.642825670698	-1.1185169019	1.23891766526	0.343585064975	3.03831567823	0.309093932762	0.94005784854	-0.429637926435	0.134437916989	0.0980198073626	-0.229154205939	-0.0277331368067	0.0926043284191	-0.300116846835	0.985261690457	0.01656926509	0.171081482303	0.745647525151	-0.189027256353	0.718061486194	84.384	-27.095	-2.313
112	1.53908778885	0.243710163563	-0.864557829839	1.86226232946	-0.892970924353	3.11459061577	-0.0444911384032	-0.125054341565	0.0883409493278	-0.180017259701	0.482515457063	-0.395264007973	0.423337840163	0.226892057329	-0.500930037175	0.999001430315	0.0524116350389	0.0964308693685	0.537356814254	-0.128026079159	0.670434914567	83.428	-32.999	-2.007
113	0.890373313424	0.435295909866	0.507846444228	1.8506196112	-0.867943195022	2.56096237616	0.254564885528	0.293418062173	-0.280915424464	-0.162243495489	0.135312641649	0.169656621293	0.953822846584	0.420430431625	-0.362823562359	1.0257057255	0.0329349281573	0.228586795853	0.716406309537	-0.149887006444	0.571324735783	70.946	-32.985	-2.729
114	1.82678868562	-3.37075844132	0.619393654854	4.80749283907	-2.62349080974	2.57148468705	-0.736548734482	-0.462143319583	0.185097477318	0.396134746134	0.788540291835	-0.859485355182	0.184550755558	0.0872758364793	0.0075163171962	1.14214564182	0.0692793931391	0.138286029924	0.976245513475	-0.309288454942	0.795035977741	70.161	-27.312	-16.794
115	2.29016850065	-1.43752705475	-1.96325847808	5.67894370189	-1.13960986308	5.86004381668	0.0949822978898	0.107161201808	0.702315025278	-0.510597777241	0.0333144549909	-0.124055604316	1.38596730754	-0.933405347242	-0.188924415818	0.847823372267	0.0627701482677	0.0715031291994	1.05827206658	-0.262457165227	0.86107283372	68.349	-40.394	-12.16
116	6.60030097725	0.33305780522	0.881661544575	4.04910008401	-0.502072215535	4.56047597337	0.50104899655	0.613382107428	-1.79638932261	1.55059940235	-0.0216558733223	-0.686606290884	-0.0280485349724	0.726359910772	-0.544224823918	1.28755436905	0.0842329112997	0.102300576625	0.77089048886	-0.322668743898	1.0705551893	72.678	-44.046	-1.389
117	3.10262363193	1.33955122788	0.729317137723	3.1523802747	1.85237731618	8.0003371548	0.965894849838	0.0828710086827	1.22126262535	-0.20827078748	0.482063276239	-1.16735151427	0.737026920029	1.15324780351	-1.14870173701	1.13211732539	0.0834958486956	0.369126789898	0.725416817816	-0.28577524512	0.977933927304	83.176	-43.249	1.328
118	1.06877713184	0.443272488679	-1.22850383571	6.25324381153	1.61956357674	0.991147108528	0.0429704665121	0.380595843172	-0.18063632666	-0.0714954136497	0.276648285332	0.298340227726	-0.158721467733	-0.322301254956	-0.235031335078	0.995270249274	-0.222361950359	-0.0145656417832	0.990911794469	0.208302264931	1.10792722244	22.643	-25.145	-8.777
119	1.05710414745	0.707642322443	-0.957706531332	3.1852095829	0.826910433882	3.35520964263	-0.231312957438	0.205528147041	0.449078382299	0.282694175171	0.223980481025	0.0573937629266	0.00469219958998	-0.377159952746	-0.140746448725	1.08256738307	-0.106389951183	-0.25501506987	0.841569038514	-0.0513762828292	0.967161467703	32.393	-31.598	-16.699
120	1.05068577232	-0.385316036563	3.2063612632	2.11564877581	-0.43627551665	3.70143571509	-0.145031364304	0.0701663071317	-0.079037474336	-0.354240223019	0.0889989788511	-0.149553655406	-0.618344064236	-0.0208140360582	0.140899234439	1.14590276516	-0.105797116111	-0.00467279522546	0.712334174488	0.113341270301	0.86230960735	46.506	-38.905	-0.079
121	5.13642856018	-2.56096626636	2.96364359896	2.33957141401	0.193175702682	3.47335105338	0.599733482816	0.525317510339	-0.0204988671202	-0.374574298273	-0.351972957097	0.307381152328	0.570504680291	0.478739051629	-0.11904311407	1.17185327817	-0.0556459058953	0.0494776872885	1.1097179668	-0.0149091474906	0.949142844848	40.252	-33.877	-22.209
122	3.26740550787	0.44817724208	-1.59679311931	0.458059443496	0.295801947358	1.29978040834	-0.238688711641	-0.55371397213	0.550100785519	-0.358113746805	0.271792945066	0.404435872039	0.229841219895	-0.900855645672	0.111228352578	1.00438266131	-0.121949530051	0.13080863256	1.0263735115	0.0605259014469	1.28734080612	11.826	10.684	-2.259
123	3.42497634381	-0.633755520817	-0.721937241381	4.5728812161	1.83962550253	4.53257308802	-0.749552929613	0.548507947717	-0.489631629617	-0.000590927202176	-0.0183147065245	-0.59609443	-0.522224753512	0.753007325815	0.676934693064	0.987991291647	-0.281608083665	-0.162624294383	0.953984410559	0.180753220291	1.09764973898	27.087	8.633	-13.167
124	2.81764589608	1.29732556425	0.850637533193	3.47231189639	1.98136590872	4.98185957233	-0.0236265076459	-0.027205437355	0.3873497459	0.73918313725	-0.800355618286	0.552033878758	0.162432169083	-0.0811591022487	0.813313375052	1.00923343103	-0.296096324145	0.0827912762277	0.964583167323	0.213406335449	0.945888460656	25.459	16.321	-14.137
125	1.64779572155	1.46051547613	-0.0777257619965	4.19233262886	-0.768745202322	2.79373037943	0.268143939118	0.0144874147915	-0.247826532753	-0.312492328908	-0.102562618372	0.449843825773	0.0789176556761	0.124081792018	-0.196974285832	0.941280663695	-0.017487598761	-0.0820897543109	0.740868453292	0.200181522538	1.05226271943	32.508	18.917	-15.883
126	2.67576176616	-3.17018987042	0.692806730214	2.76099159918	-0.200827093647	0.892696462147	0.132411788611	0.127892849326	-0.00403186058344	-0.0119361420699	-0.176688570342	0.0183314414954	0.0441039464061	0.0823306198544	0.25126659234	1.10776780234	-0.01891758748	0.134293153001	0.945191613004	0.0902282242631	0.748984724822	50.885	10.832	-19.617
127	4.4176028334	-0.622801293025	0.722672450115	3.32279683332	-0.897529095908	1.89652756745	0.487307531749	0.185393837469	1.2141670335	-0.263458996301	-0.0401974672576	-0.113848131622	-0.103090209141	-0.0742507736687	-0.591548005257	1.01727517804	-0.111689322245	0.143473485311	0.722797883509	0.22678657186	0.954416936873	38.295	29.314	-13.267
128	2.73511348044	0.679137090732	0.925725137936	1.90669003676	-0.0327495182773	2.34700457831	0.0978642736778	0.140599381189	0.277664964648	0.217403784534	-0.0328375136742	-0.128846423032	0.0452615850613	-0.0910611522088	-0.0152174292131	0.929504170976	-0.0259363613387	0.148961715978	0.800225887835	-0.057321523403	0.637577621739	86.467	-6.61	-9.138
129	1.59474735126	-1.95933129304	-1.06115237167	2.82165963359	1.53896477342	1.47796501194	0.236004840624	0.116414259095	-0.00680250414992	-0.696822040365	-0.345585591653	-0.0429814777003	-0.0296720161905	0.211969940386	0.0889768153977	1.05712426978	-0.074565983643	0.158292481324	0.798657497547	-0.00162280413623	0.601711204382	73.507	-3.782	-22.375
130	3.94670558017	-0.57214851401	2.10624692219	0.396103275059	1.08855846195	3.41935685524	-0.254964907001	1.10544758947	0.374280776876	-0.206233498965	-0.297742201777	0.309325314138	-0.397055558004	-0.102903399599	0.507186827697	0.965595945468	-0.0152858192351	0.0391690512287	1.063217962	0.0458242200432	1.54290143192	9.646	-18.904	13.046
131	4.25986609681	0.965682272398	0.314783789844	4.69615219985	1.0092718555	3.81597153924	-0.804331585519	-0.154310391614	-0.470747415279	0.879844827165	0.498499817861	1.37172806124	-0.346773406917	0.0640809127588	0.273202796479	1.00259298913	0.0369056368627	0.168815531211	0.750160017025	0.189948545981	1.09289757236	18.23	-11.095	27.469
132	1.83712939195	-1.43062708799	1.03482611237	2.0705044141	0.361067266952	4.70323935516	-0.03286839217	0.252757368902	0.305899008893	0.218874272871	0.127397381291	0.600630834133	-0.293087159192	-0.472447988774	-0.0158747347081	0.813179944877	0.0921333439705	0.208020643624	0.884159875043	0.32350624901	1.13334959143	19.842	-18.609	34.782
133	2.1684195957	3.75174911193	-0.723510458072	4.73173699873	-0.15191059363	1.15080839394	0.0116167844388	0.65228469887	0.464097025512	0.698034833055	0.784274908547	0.665528019839	-0.253128238206	-0.322636463951	-0.905063910221	0.985607085796	0.0641315714558	0.256685224958	0.827306357354	0.15743497328	0.951466425326	37.155	-8.326	43.12
134	4.31313694893	-0.495484110047	2.06326928175	6.01846520662	1.44877927485	7.44568390157	0.200854144808	-1.139909149	-0.609557014236	1.16627959024	0.16759460281	-0.377304540089	1.44884644202	0.523944567872	-0.603070454739	1.00337212532	0.178662638697	0.0905422807728	1.07233558947	0.114318153754	0.696939548073	31.63	-25.94	44.865
135	1.14165937424	-1.60578234205	-1.44317399769	5.03839588361	4.90634211658	8.40589622536	-0.559635283707	0.807801456294	-0.0907989705672	-0.463047145033	-0.321906518047	0.129893046075	1.03273983602	-1.40156008999	0.424698263885	1.11811346233	-0.266199116684	0.295398597557	0.987772609724	0.26096398823	1.16320556339	17.488	-33.256	33.609
136	4.56713953494	0.842447631886	-0.716137041323	2.53981504801	-0.183113424486	4.67407397954	-0.908316603264	-0.808213989911	0.368109249689	-0.127064757714	0.33506652001	-0.110962431996	-0.211224009957	0.303683946603	0.477184732389	1.1028488819	0.0953505093828	0.0373689431415	0.887877263745	-0.0744049212725	0.757962587435	80.428	5.4	33.721
137	8.34608696492	1.42299534885	1.5629748832	6.62211166373	-0.0523224359697	5.69808686116	-0.169887722588	-0.0454898334732	-0.368907814723	-0.438664251271	0.777273846565	-0.90913048475	0.828771033423	1.37812057597	-0.0649113235969	0.920010375022	0.0886867380472	0.135401432962	1.26091829568	-0.220675961393	0.862906222642	78.867	-2.271	39.634
138	2.54393849236	-0.75574675782	-1.38828107192	0.673668337387	-0.860543829312	3.23600565158	0.256080959733	-0.525263445016	0.300999405699	0.290271697604	-0.0113777159461	-0.178529661779	0.228925421773	0.217918637235	-0.213481799643	0.941691508796	0.102495359706	-0.104433225835	0.835551026806	-0.286515978986	0.801713450745	73.507	6.112	44.197
139	3.72267313698	0.975969947635	2.40050181079	1.95322432158	0.782582985931	2.76469765002	-0.285353128872	-1.0653901722	0.153352438685	-0.0460429161251	0.351210129546	-0.361764117199	-0.550867421342	-0.0267820632314	-0.0098326263054	0.906217422211	-0.0473988247718	0.272663430029	0.879494715477	-0.251713652363	0.687273617167	64.342	10.656	43.673
140	7.37484503475	6.62422052219	1.95067084638	9.98508902234	2.25730294155	1.61657742356	-0.15223857408	-0.19457142452	-0.533634373317	0.390512099099	0.0853382715255	-0.423412573325	-0.0933056292497	-0.194471649333	0.128825182964	1.09565462701	0.21386996351	0.147795803621	0.852707603328	-0.108571816513	0.589362446153	55.395	-0.631	50.232
141	5.81578966044	-2.40292794559	4.37088395923	3.55473446801	-0.647984850603	6.86609209174	-0.0373258777	0.239888796266	-0.268101953094	1.37767092782	-0.293129978357	0.574637972458	-0.642813510126	-0.780153785185	0.19529019173	1.15588318024	0.0533011064852	0.310659387782	1.09046758842	-0.302039124413	1.0043623228	56.188	13.664	54.65
142	4.53579693195	-0.143190104575	0.434126035282	4.05137083904	-1.92826356643	1.9804450819	0.437155921937	-0.0346948654348	0.910438383906	-0.330648043363	0.207735721245	0.121607497069	-0.206049175041	0.314004814312	-0.7420557443	0.864942718748	0.192243124511	-0.00577520550369	0.836007735157	-0.288712288015	0.840439076152	64.138	19.016	45.88
143	3.7809027681	-1.55946859222	0.809743992331	1.70242567564	0.905246890182	0.581970910668	0.534852366235	1.13621456711	0.102090529213	0.772480847918	-0.760507309813	1.49605565187	-0.137291513051	0.0694687467359	0.358290796369	0.945566324664	-0.055738233512	0.195821739075	1.01256873387	0.147528524856	1.40440883707	7.175	-5.43	18.859
144	1.55392583835	0.368925779222	0.918863160181	3.93827731378	0.30300487962	3.76863951316	-0.0919175803285	-1.1005165286	-0.0526282129386	-0.0194008023214	0.400161328667	0.867723097689	0.262392129856	0.145518610403	-0.184214105178	0.853069678931	0.226484828704	0.221669006171	0.916325443162	0.26926643128	1.16131183295	17.683	8.188	25.597
145	0.743253606247	-0.625594333728	0.827764479296	2.71499795716	-0.537752555806	4.0088459583	0.218554952267	0.417911929428	0.241965442579	0.528612766465	0.439113636594	0.756934371147	-0.567193844728	-0.371294856401	-0.573426143774	0.707355382314	0.270124235543	0.261217869767	1.08258539042	0.139352462069	0.948376714832	21.585	10.213	34.591
146	4.7887717657	1.47636888487	-3.73033115039	3.47516864091	-1.66678510386	2.66589079317	-0.553613975235	0.652233493616	0.278823563284	0.0207341875336	0.779836761206	0.351135396221	0.0991637698556	-0.518559034791	-0.148600841768	1.10528483888	0.171507575611	0.242259052896	0.805604871752	0.051816686187	0.897942585825	39.615	19.427	32.162
147	2.78638284286	-0.498244184541	0.972200030672	4.09674148895	0.561338295738	3.26814266891	-0.050863813855	-1.35379288999	-0.419100853139	0.621642026294	0.0156224258896	0.339183039041	0.227001493109	-0.119119300587	0.139463766401	0.95231031906	0.161842329501	0.283917695788	0.944930492453	0.128289484877	0.807924194615	26.855	7.98	45.703
148	0.172587078194	0.397750856405	0.352261463716	5.53163653067	-0.188818363892	0.97945021884	0.415491635322	0.168823144145	0.310010522643	-0.611817773728	-0.00227025741446	-0.04485257104	-1.747900677	-0.855297605756	-0.286738676209	1.40279100175	0.272379308591	0.176562716357	1.26948703154	-0.0131263457823	0.626054468203	85.399	-19.775	27.03
149	4.28635335213	0.289763131186	1.09748275996	4.28316372794	0.18125301164	4.07866877666	-0.86592456688	0.024762836448	-0.31521748212	0.678736446318	0.56062755316	0.140429212564	-0.535503815425	0.348105001704	0.678365725615	0.911039984529	0.108070787358	0.134606328404	0.864187105912	-0.138644892394	0.789071491255	81.81	-28.593	19.965
150	0.512910614547	0.560998035651	-0.482426837747	4.10104324535	2.01220434414	1.75611025804	0.205950416184	0.277215478788	-0.687762370214	-0.132154808476	-0.115638531805	-0.214563409976	-0.179244237349	0.152873563148	-0.203873572451	0.970719628434	0.16617147281	0.104527077332	0.64583607823	-0.044564294528	0.78379231206	77.901	-36.074	22.881
151	2.68551479213	-1.57045012618	-0.780720194251	1.81740082812	0.314908653695	2.55288835216	1.01037215371	-0.530442389303	-0.178837450427	-0.60513952966	-0.454447680681	-0.413098565489	-1.68928136433	0.628724075658	-0.103704918655	1.35527073534	-0.0194962849449	0.262915739907	1.00065136106	-0.00811448265603	0.736894175931	79.128	-41.779	30.391
152	4.77350054614	-1.28103052128	2.82627854764	1.19862813463	1.38473711737	9.38343060616	0.934323718711	-0.258379293457	-0.835946421388	-0.0485183952175	0.370126277621	0.0266718500131	0.881796194413	-0.73545338023	-0.956051485637	0.839106885336	0.0025493071812	0.164051622119	0.430697996983	0.0164947222923	0.918468485957	61.532	-36.104	21.543
153	3.14532816187	-0.376649673229	3.39246185208	2.32534845895	-0.434213015132	4.64559051991	-0.552425613016	0.109450239771	-0.415647549506	0.176173667912	0.268081276576	0.0455713998545	-0.68163666156	0.054897726607	0.311250361769	1.26399711048	0.0592500862687	0.148692806782	0.634096031015	-0.069796603364	0.801235418338	63.73	-43.952	10.802
154	3.36546049394	-5.35856584992	1.28220538438	9.16213049881	-1.62446023395	1.11971328492	-1.48255139124	1.09018008023	-2.33877414701	-0.384855515257	0.451089031077	1.77585019194	-0.603986741009	0.461556349444	0.823819838532	1.14907250536	0.0314660634173	-0.186707277148	0.603265100601	-0.147234298895	1.24426011242	62.333	-50.489	23.746
155	4.51931199897	0.322980041429	3.23788682591	2.35526664	0.255843111526	6.04049416081	0.748859928604	-0.87372448781	-0.0352473336049	0.144993779202	-0.351153952994	-0.144384258992	-0.0401311466106	-1.19750737362	-0.315092713869	1.09535680383	0.0907885895896	-0.00267981557087	0.723245816671	0.0747289843668	0.793353436326	62.661	-42.278	31.229
156	3.90588478248	-1.55693072284	4.64156491731	3.86824184746	-1.91973357687	4.94121029688	1.08006454947	0.421402197301	-0.66471196378	0.718676155087	-0.22967793104	-0.135356026317	1.33627041967	0.625492238115	-0.86332173968	1.03938392622	0.184506818138	0.332031862914	0.800599077762	0.139561695917	0.807593740507	75.578	-42.198	35.635
157	8.7302190292	-4.90856439252	-1.91281243602	8.58140247295	-4.82651555716	6.29765801204	-2.06369450159	0.214832607315	-2.67658583266	1.12999679859	1.68919880247	0.684258468885	-0.119257016164	0.926968624066	-0.0389125335288	1.2045524849	-0.0667454345986	0.155296882639	0.935289926833	-0.225195653941	1.03339497239	87.385	9.677	17
158	4.3228576642	-1.32514837648	-0.633069451191	4.12496945814	-0.452345652628	1.96389769868	0.0162243755632	-0.995708824435	0.871240905534	0.0161417601632	0.196954758596	-0.201667956653	0.32389347964	0.676509798274	-0.225913829673	0.939329987856	0.0342455039227	0.185280823301	0.901700410208	-0.236608426336	0.86608085282	81.098	17.453	24.469
159	1.2817573923	-0.281338252485	-0.54559881809	2.20298816239	-0.192226910712	1.86946519807	-0.0701799658536	0.142856126983	-0.0330513091335	0.654746279676	0.124781045189	-0.109385624438	-0.267982598888	0.0960116236881	0.161814859947	1.09275491854	-0.139538189171	0.0317861961142	0.712791081286	-0.143143779247	0.851369118114	75.877	23.991	25.565
160	2.68348711899	0.825265278662	0.427616546441	1.70516340527	-0.807024652437	3.19215060866	0.266274451379	-0.345787361273	0.883445364171	0.105469156844	-0.567078998872	-0.0767472177066	0.289951928738	0.451854336466	0.422269897188	0.812334537971	-0.108675289088	0.164270875903	0.738725157503	-0.186421857953	1.00684059916	76.812	30.645	17.226
161	1.67251751309	0.786519038443	0.491296409199	3.76711305012	-0.109117380608	0.539012057273	-0.0746374108928	0.271182737017	0.434765383576	-0.788373146262	0.225822250241	0.937094014764	-0.611864308594	-0.528172054493	0.426008591168	1.0702182933	0.168703148123	-0.0531035865548	0.74557558012	-0.336753015059	0.983466857048	54.076	19.996	26.055
162	4.70674474792	2.66495694237	-0.663016449559	3.03496918928	-1.37253678127	1.98169917899	0.288443478123	-0.66246337874	0.770233783557	0.773831835457	0.0821939802517	0.121155248829	-0.544387397533	0.360376938012	-0.298837756211	1.15996342027	0.134969145815	0.0902888236354	0.92023712136	-0.188989417312	1.00699889132	59.367	26.685	32.306
163	9.64607029059	4.01603647685	2.5303743209	1.86188963128	0.182886624278	7.52561488586	-0.0550695799923	-0.953454335135	0.968841045454	2.13484878255	0.531298318092	0.479410281666	-0.644821082894	0.241789175432	-0.558970082833	1.09798594507	0.0449972999217	0.297314258837	0.840569627983	-0.239160558348	1.30065151978	62.415	38.123	23.933
164	7.99318383965	3.57789431815	1.86771074079	5.36229450644	1.17016429097	3.10473777946	-0.603615190899	0.922427478457	0.73459662721	-1.66727597048	0.572628376884	-0.353842781915	-1.27316516801	0.228157199458	0.0652372035482	0.971192778164	-0.0927982719533	0.224615372119	0.646946868401	-0.0321090100301	1.08041821032	66.417	33.909	14.317
165	4.85754002447	2.36383138758	1.22912282138	3.63533167798	-0.804542569988	2.83123555504	-0.366713507375	-1.05459228231	1.91906051054	0.059118336356	-0.390912232214	1.55331605556	-0.316789035015	0.458702742059	0.0806784341778	1.06521933695	-0.208115797789	0.0171568232305	0.992875148522	-0.31451434301	1.12607344489	80.014	34.465	15.817
166	7.43368481399	-1.20459721305	2.41876614182	1.45021844973	-0.736880338946	2.37185891986	1.38251267107	-0.902587310389	0.848988193847	-0.388022832563	-0.193766673614	0.234499016263	0.448654740699	-1.34062460939	-1.23363379277	1.28352414024	-0.0975419648627	0.101999838577	1.06212461536	0.371721117857	1.53576852625	5.664	5.595	13.881
167	2.61523561559	0.46219671887	0.326840855693	4.25268442276	1.23461810798	2.70013537558	0.109572288369	0.168070986167	-0.158021234874	-0.298284968323	0.191802304998	-0.0487034954328	0.183331371609	-0.364415036267	-0.337979305459	0.904626366854	0.0905269929943	0.130909914218	0.896831709965	0.148185917252	0.89935668059	19.228	17.063	7.86
168	0.239921664782	-0.6705918639	-0.92533342747	2.77000861436	1.56198815441	2.53790457401	0.204970858669	0.226292463081	0.115450198196	-0.311771344688	0.195539250221	-0.428344754327	-0.462735804837	-0.51238258265	-0.42026465194	0.818296341443	0.10592858632	0.127870692658	0.766925537706	0.124342603738	1.05579026614	26.606	26.94	11.427
169	3.76891023276	-1.74357615821	-2.47964837801	1.83874090744	1.0496376816	2.68847310283	-0.246520361584	-0.163838822103	-0.907207477706	-0.167117650604	0.0504365432321	0.330200542498	-0.313186981176	-0.481418738343	0.190951991282	1.16126539022	0.128169503932	0.204333927176	0.904884997772	0.114027762347	0.911047378158	45.678	27.942	4.146
170	5.37311493227	0.881191247404	-1.6790579494	3.11994207782	0.587156512969	3.77065188069	0.667722905781	-0.743962024516	0.773621626345	-0.0736241120589	-0.32105599715	-0.0617974876305	-0.736825636755	0.202962411748	-0.465955906297	1.03130609304	0.0846944450656	0.193397183651	0.86610343133	-0.00590855536842	0.859132677415	32.338	33.076	20.7
171	2.0085672588	0.672071728213	-0.0396155336812	3.91386878174	-0.803978517599	1.7338147254	0.596635063432	-1.19301624573	0.514874982336	0.348471665644	0.118113712769	-0.0220240052343	0.884998516001	1.6859570432	-0.55388111256	1.12032621575	-0.343126421251	0.0957338347797	1.55680512754	-0.290211146212	0.69639071021	89.93	2.711	6.111
172	5.92064402677	-1.70790400112	-0.484303495938	5.04507664114	-0.725646975871	4.2664863421	-0.441348628416	0.53437173478	0.441868835992	0.247838382281	0.780780519995	-0.000637856252927	0.409487913841	-0.218698734828	-0.159509212963	0.958369312046	-0.0132430031356	0.0839359991874	0.741117051624	0.0659254963556	0.779006319088	84.785	13.054	6.596
173	3.16234766554	0.208526362711	1.18595103966	1.98075577387	0.22592738433	2.96593330904	0.15020500748	0.0347425284552	0.29422919024	0.314863908133	-0.337750470209	-0.106422161655	0.261447674374	0.183887272981	0.293856553485	0.911821727085	-0.0500066058734	0.128593734561	0.782706614328	-0.0672850849443	0.724936795519	83.218	18.266	-0.445
174	4.41438444097	2.27910368879	0.964694782753	6.17855278521	2.08763980522	4.74674989626	-0.99721516905	0.515220700047	-0.0740810583218	-1.03347250765	1.16845182145	-0.212849019421	-0.826686846835	0.665891606311	-0.276964151371	0.920064268846	-0.054638188362	0.113587219902	0.826084541002	0.0444167984801	0.719238495728	83.026	17.396	-10.827
175	3.52009636622	-0.32502174796	0.138319916712	3.65330649786	1.50404653358	3.38363088728	0.312880246881	0.401032860926	0.526766853728	-0.104597588557	0.000770037426178	0.0473957119064	-0.529648773422	0.298095323998	-0.183610429342	1.05398552415	-0.102666453341	0.0399000887124	0.733545343841	0.0396890049802	0.834728172542	64.552	27.352	0.261
176	8.73554185662	5.13069412119	3.15504967802	8.8548622696	-1.97733561907	3.57844392452	-0.431608978827	0.366135373183	-0.356488694095	0.0765226808464	0.0622827731029	-1.09132925936	-1.60616993969	-0.483712180153	0.597588255074	1.05393813384	0.0385165722204	0.279602354992	0.777643488926	0.0561157810927	1.33594917386	70.682	29.375	-14.019
177	3.27290055314	0.574132707476	0.134342749766	0.978216614925	-0.0930660698777	1.90194841111	0.676033028546	-0.343566665503	0.582310436193	0.239090556649	-0.251170982011	0.00874790826071	0.563242314622	-0.113420752222	-0.0834355018217	1.10356937371	-0.0233226681819	0.197827618373	0.754592167119	0.0470352084244	0.906459840733	77.93	18.666	-15.616

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	( CHAIN A AND RESID 15:39 )	A	15 - 39
2	X-RAY DIFFRACTION	2	( CHAIN A AND RESID 40:95 )	A	40 - 95
3	X-RAY DIFFRACTION	3	( CHAIN A AND RESID 96:134 )	A	96 - 134
4	X-RAY DIFFRACTION	4	( CHAIN A AND RESID 135:172 )	A	135 - 172
5	X-RAY DIFFRACTION	5	( CHAIN A AND RESID 173:208 )	A	173 - 208
6	X-RAY DIFFRACTION	6	( CHAIN B AND RESID 16:26 )	B	16 - 26
7	X-RAY DIFFRACTION	7	( CHAIN B AND RESID 27:70 )	B	27 - 70
8	X-RAY DIFFRACTION	8	( CHAIN B AND RESID 71:115 )	B	71 - 115
9	X-RAY DIFFRACTION	9	( CHAIN B AND RESID 116:132 )	B	116 - 132
10	X-RAY DIFFRACTION	10	( CHAIN B AND RESID 133:158 )	B	133 - 158
11	X-RAY DIFFRACTION	11	( CHAIN B AND RESID 159:169 )	B	159 - 169
12	X-RAY DIFFRACTION	12	( CHAIN B AND RESID 170:192 )	B	170 - 192
13	X-RAY DIFFRACTION	13	( CHAIN C AND RESID 15:38 )	C	15 - 38
14	X-RAY DIFFRACTION	14	( CHAIN C AND RESID 39:134 )	C	39 - 134
15	X-RAY DIFFRACTION	15	( CHAIN C AND RESID 135:186 )	C	135 - 186
16	X-RAY DIFFRACTION	16	( CHAIN C AND RESID 187:210 )	C	187 - 210
17	X-RAY DIFFRACTION	17	( CHAIN D AND RESID 17:26 )	D	17 - 26
18	X-RAY DIFFRACTION	18	( CHAIN D AND RESID 27:54 )	D	27 - 54
19	X-RAY DIFFRACTION	19	( CHAIN D AND RESID 55:82 )	D	55 - 82
20	X-RAY DIFFRACTION	20	( CHAIN D AND RESID 83:111 )	D	83 - 111
21	X-RAY DIFFRACTION	21	( CHAIN D AND RESID 112:132 )	D	112 - 132
22	X-RAY DIFFRACTION	22	( CHAIN D AND RESID 133:158 )	D	133 - 158
23	X-RAY DIFFRACTION	23	( CHAIN D AND RESID 159:172 )	D	159 - 172
24	X-RAY DIFFRACTION	24	( CHAIN D AND RESID 173:183 )	D	173 - 183
25	X-RAY DIFFRACTION	25	( CHAIN D AND RESID 184:191 )	D	184 - 191
26	X-RAY DIFFRACTION	26	( CHAIN F AND RESID 15:95 )	F	15 - 95
27	X-RAY DIFFRACTION	27	( CHAIN F AND RESID 96:134 )	F	96 - 134
28	X-RAY DIFFRACTION	28	( CHAIN F AND RESID 135:172 )	F	135 - 172
29	X-RAY DIFFRACTION	29	( CHAIN F AND RESID 173:210 )	F	173 - 210
30	X-RAY DIFFRACTION	30	( CHAIN H AND RESID 15:39 )	H	15 - 39
31	X-RAY DIFFRACTION	31	( CHAIN H AND RESID 40:66 )	H	40 - 66
32	X-RAY DIFFRACTION	32	( CHAIN H AND RESID 67:82 )	H	67 - 82
33	X-RAY DIFFRACTION	33	( CHAIN H AND RESID 83:134 )	H	83 - 134
34	X-RAY DIFFRACTION	34	( CHAIN H AND RESID 135:172 )	H	135 - 172
35	X-RAY DIFFRACTION	35	( CHAIN H AND RESID 173:210 )	H	173 - 210
36	X-RAY DIFFRACTION	36	( CHAIN I AND RESID 17:122 )	I	17 - 122
37	X-RAY DIFFRACTION	37	( CHAIN I AND RESID 123:191 )	I	123 - 191
38	X-RAY DIFFRACTION	38	( CHAIN J AND RESID 14:39 )	J	14 - 39
39	X-RAY DIFFRACTION	39	( CHAIN J AND RESID 40:66 )	J	40 - 66
40	X-RAY DIFFRACTION	40	( CHAIN J AND RESID 67:134 )	J	67 - 134
41	X-RAY DIFFRACTION	41	( CHAIN J AND RESID 135:172 )	J	135 - 172
42	X-RAY DIFFRACTION	42	( CHAIN J AND RESID 173:197 )	J	173 - 197
43	X-RAY DIFFRACTION	43	( CHAIN J AND RESID 198:208 )	J	198 - 208
44	X-RAY DIFFRACTION	44	( CHAIN K AND RESID 17:37 )	K	17 - 37
45	X-RAY DIFFRACTION	45	( CHAIN K AND RESID 38:54 )	K	38 - 54
46	X-RAY DIFFRACTION	46	( CHAIN K AND RESID 55:92 )	K	55 - 92
47	X-RAY DIFFRACTION	47	( CHAIN K AND RESID 93:122 )	K	93 - 122
48	X-RAY DIFFRACTION	48	( CHAIN K AND RESID 123:132 )	K	123 - 132
49	X-RAY DIFFRACTION	49	( CHAIN K AND RESID 133:158 )	K	133 - 158
50	X-RAY DIFFRACTION	50	( CHAIN K AND RESID 159:168 )	K	159 - 168
51	X-RAY DIFFRACTION	51	( CHAIN K AND RESID 169:191 )	K	169 - 191
52	X-RAY DIFFRACTION	52	( CHAIN L AND RESID 15:38 )	L	15 - 38
53	X-RAY DIFFRACTION	53	( CHAIN L AND RESID 39:82 )	L	39 - 82
54	X-RAY DIFFRACTION	54	( CHAIN L AND RESID 83:134 )	L	83 - 134
55	X-RAY DIFFRACTION	55	( CHAIN L AND RESID 135:172 )	L	135 - 172
56	X-RAY DIFFRACTION	56	( CHAIN L AND RESID 173:207 )	L	173 - 207
57	X-RAY DIFFRACTION	57	( CHAIN M AND RESID 16:26 )	M	16 - 26
58	X-RAY DIFFRACTION	58	( CHAIN M AND RESID 27:54 )	M	27 - 54
59	X-RAY DIFFRACTION	59	( CHAIN M AND RESID 55:83 )	M	55 - 83
60	X-RAY DIFFRACTION	60	( CHAIN M AND RESID 84:105 )	M	84 - 105
61	X-RAY DIFFRACTION	61	( CHAIN M AND RESID 106:115 )	M	106 - 115
62	X-RAY DIFFRACTION	62	( CHAIN M AND RESID 116:132 )	M	116 - 132
63	X-RAY DIFFRACTION	63	( CHAIN M AND RESID 133:158 )	M	133 - 158
64	X-RAY DIFFRACTION	64	( CHAIN M AND RESID 159:169 )	M	159 - 169
65	X-RAY DIFFRACTION	65	( CHAIN M AND RESID 170:183 )	M	170 - 183
66	X-RAY DIFFRACTION	66	( CHAIN M AND RESID 184:191 )	M	184 - 191
67	X-RAY DIFFRACTION	67	( CHAIN N AND RESID 16:26 )	N	16 - 26
68	X-RAY DIFFRACTION	68	( CHAIN N AND RESID 27:70 )	N	27 - 70
69	X-RAY DIFFRACTION	69	( CHAIN N AND RESID 71:104 )	N	71 - 104
70	X-RAY DIFFRACTION	70	( CHAIN N AND RESID 105:122 )	N	105 - 122
71	X-RAY DIFFRACTION	71	( CHAIN N AND RESID 123:132 )	N	123 - 132
72	X-RAY DIFFRACTION	72	( CHAIN N AND RESID 133:158 )	N	133 - 158
73	X-RAY DIFFRACTION	73	( CHAIN N AND RESID 159:172 )	N	159 - 172
74	X-RAY DIFFRACTION	74	( CHAIN N AND RESID 173:183 )	N	173 - 183
75	X-RAY DIFFRACTION	75	( CHAIN N AND RESID 184:191 )	N	184 - 191
76	X-RAY DIFFRACTION	76	( CHAIN E AND RESID 15:25 )	E	15 - 25
77	X-RAY DIFFRACTION	77	( CHAIN E AND RESID 26:82 )	E	26 - 82
78	X-RAY DIFFRACTION	78	( CHAIN E AND RESID 83:134 )	E	83 - 134
79	X-RAY DIFFRACTION	79	( CHAIN E AND RESID 135:172 )	E	135 - 172
80	X-RAY DIFFRACTION	80	( CHAIN E AND RESID 173:207 )	E	173 - 207
81	X-RAY DIFFRACTION	81	( CHAIN G AND RESID 16:26 )	G	16 - 26
82	X-RAY DIFFRACTION	82	( CHAIN G AND RESID 27:54 )	G	27 - 54
83	X-RAY DIFFRACTION	83	( CHAIN G AND RESID 55:104 )	G	55 - 104
84	X-RAY DIFFRACTION	84	( CHAIN G AND RESID 105:122 )	G	105 - 122
85	X-RAY DIFFRACTION	85	( CHAIN G AND RESID 123:158 )	G	123 - 158
86	X-RAY DIFFRACTION	86	( CHAIN G AND RESID 159:169 )	G	159 - 169
87	X-RAY DIFFRACTION	87	( CHAIN G AND RESID 170:191 )	G	170 - 191
88	X-RAY DIFFRACTION	88	( CHAIN O AND RESID 15:39 )	O	15 - 39
89	X-RAY DIFFRACTION	89	( CHAIN O AND RESID 40:82 )	O	40 - 82
90	X-RAY DIFFRACTION	90	( CHAIN O AND RESID 83:117 )	O	83 - 117
91	X-RAY DIFFRACTION	91	( CHAIN O AND RESID 118:134 )	O	118 - 134
92	X-RAY DIFFRACTION	92	( CHAIN O AND RESID 135:172 )	O	135 - 172
93	X-RAY DIFFRACTION	93	( CHAIN O AND RESID 173:197 )	O	173 - 197
94	X-RAY DIFFRACTION	94	( CHAIN O AND RESID 198:208 )	O	198 - 208
95	X-RAY DIFFRACTION	95	( CHAIN P AND RESID 16:26 )	P	16 - 26
96	X-RAY DIFFRACTION	96	( CHAIN P AND RESID 27:37 )	P	27 - 37
97	X-RAY DIFFRACTION	97	( CHAIN P AND RESID 38:54 )	P	38 - 54
98	X-RAY DIFFRACTION	98	( CHAIN P AND RESID 55:92 )	P	55 - 92
99	X-RAY DIFFRACTION	99	( CHAIN P AND RESID 93:115 )	P	93 - 115
100	X-RAY DIFFRACTION	100	( CHAIN P AND RESID 116:132 )	P	116 - 132
101	X-RAY DIFFRACTION	101	( CHAIN P AND RESID 133:158 )	P	133 - 158
102	X-RAY DIFFRACTION	102	( CHAIN P AND RESID 159:169 )	P	159 - 169
103	X-RAY DIFFRACTION	103	( CHAIN P AND RESID 170:183 )	P	170 - 183
104	X-RAY DIFFRACTION	104	( CHAIN P AND RESID 184:192 )	P	184 - 192
105	X-RAY DIFFRACTION	105	( CHAIN Q AND RESID 15:38 )	Q	15 - 38
106	X-RAY DIFFRACTION	106	( CHAIN Q AND RESID 39:134 )	Q	39 - 134
107	X-RAY DIFFRACTION	107	( CHAIN Q AND RESID 135:186 )	Q	135 - 186
108	X-RAY DIFFRACTION	108	( CHAIN Q AND RESID 187:210 )	Q	187 - 210
109	X-RAY DIFFRACTION	109	( CHAIN R AND RESID 17:26 )	R	17 - 26
110	X-RAY DIFFRACTION	110	( CHAIN R AND RESID 27:54 )	R	27 - 54
111	X-RAY DIFFRACTION	111	( CHAIN R AND RESID 55:82 )	R	55 - 82
112	X-RAY DIFFRACTION	112	( CHAIN R AND RESID 83:111 )	R	83 - 111
113	X-RAY DIFFRACTION	113	( CHAIN R AND RESID 112:132 )	R	112 - 132
114	X-RAY DIFFRACTION	114	( CHAIN R AND RESID 133:158 )	R	133 - 158
115	X-RAY DIFFRACTION	115	( CHAIN R AND RESID 159:172 )	R	159 - 172
116	X-RAY DIFFRACTION	116	( CHAIN R AND RESID 173:183 )	R	173 - 183
117	X-RAY DIFFRACTION	117	( CHAIN R AND RESID 184:191 )	R	184 - 191
118	X-RAY DIFFRACTION	118	( CHAIN S AND RESID 15:95 )	S	15 - 95
119	X-RAY DIFFRACTION	119	( CHAIN S AND RESID 96:134 )	S	96 - 134
120	X-RAY DIFFRACTION	120	( CHAIN S AND RESID 135:172 )	S	135 - 172
121	X-RAY DIFFRACTION	121	( CHAIN S AND RESID 173:210 )	S	173 - 210
122	X-RAY DIFFRACTION	122	( CHAIN T AND RESID 15:39 )	T	15 - 39
123	X-RAY DIFFRACTION	123	( CHAIN T AND RESID 40:66 )	T	40 - 66
124	X-RAY DIFFRACTION	124	( CHAIN T AND RESID 67:82 )	T	67 - 82
125	X-RAY DIFFRACTION	125	( CHAIN T AND RESID 83:134 )	T	83 - 134
126	X-RAY DIFFRACTION	126	( CHAIN T AND RESID 135:172 )	T	135 - 172
127	X-RAY DIFFRACTION	127	( CHAIN T AND RESID 173:210 )	T	173 - 210
128	X-RAY DIFFRACTION	128	( CHAIN U AND RESID 17:122 )	U	17 - 122
129	X-RAY DIFFRACTION	129	( CHAIN U AND RESID 123:191 )	U	123 - 191
130	X-RAY DIFFRACTION	130	( CHAIN V AND RESID 14:39 )	V	14 - 39
131	X-RAY DIFFRACTION	131	( CHAIN V AND RESID 40:66 )	V	40 - 66
132	X-RAY DIFFRACTION	132	( CHAIN V AND RESID 67:134 )	V	67 - 134
133	X-RAY DIFFRACTION	133	( CHAIN V AND RESID 135:172 )	V	135 - 172
134	X-RAY DIFFRACTION	134	( CHAIN V AND RESID 173:197 )	V	173 - 197
135	X-RAY DIFFRACTION	135	( CHAIN V AND RESID 198:208 )	V	198 - 208
136	X-RAY DIFFRACTION	136	( CHAIN W AND RESID 17:37 )	W	17 - 37
137	X-RAY DIFFRACTION	137	( CHAIN W AND RESID 38:54 )	W	38 - 54
138	X-RAY DIFFRACTION	138	( CHAIN W AND RESID 55:104 )	W	55 - 104
139	X-RAY DIFFRACTION	139	( CHAIN W AND RESID 105:132 )	W	105 - 132
140	X-RAY DIFFRACTION	140	( CHAIN W AND RESID 133:158 )	W	133 - 158
141	X-RAY DIFFRACTION	141	( CHAIN W AND RESID 159:168 )	W	159 - 168
142	X-RAY DIFFRACTION	142	( CHAIN W AND RESID 169:191 )	W	169 - 191
143	X-RAY DIFFRACTION	143	( CHAIN X AND RESID 15:38 )	X	15 - 38
144	X-RAY DIFFRACTION	144	( CHAIN X AND RESID 39:82 )	X	39 - 82
145	X-RAY DIFFRACTION	145	( CHAIN X AND RESID 83:134 )	X	83 - 134
146	X-RAY DIFFRACTION	146	( CHAIN X AND RESID 135:172 )	X	135 - 172
147	X-RAY DIFFRACTION	147	( CHAIN X AND RESID 173:207 )	X	173 - 207
148	X-RAY DIFFRACTION	148	( CHAIN Y AND RESID 16:26 )	Y	16 - 26
149	X-RAY DIFFRACTION	149	( CHAIN Y AND RESID 27:54 )	Y	27 - 54
150	X-RAY DIFFRACTION	150	( CHAIN Y AND RESID 55:105 )	Y	55 - 105
151	X-RAY DIFFRACTION	151	( CHAIN Y AND RESID 106:115 )	Y	106 - 115
152	X-RAY DIFFRACTION	152	( CHAIN Y AND RESID 116:132 )	Y	116 - 132
153	X-RAY DIFFRACTION	153	( CHAIN Y AND RESID 133:158 )	Y	133 - 158
154	X-RAY DIFFRACTION	154	( CHAIN Y AND RESID 159:169 )	Y	159 - 169
155	X-RAY DIFFRACTION	155	( CHAIN Y AND RESID 170:183 )	Y	170 - 183
156	X-RAY DIFFRACTION	156	( CHAIN Y AND RESID 184:191 )	Y	184 - 191
157	X-RAY DIFFRACTION	157	( CHAIN Z AND RESID 16:26 )	Z	16 - 26
158	X-RAY DIFFRACTION	158	( CHAIN Z AND RESID 27:70 )	Z	27 - 70
159	X-RAY DIFFRACTION	159	( CHAIN Z AND RESID 71:104 )	Z	71 - 104
160	X-RAY DIFFRACTION	160	( CHAIN Z AND RESID 105:122 )	Z	105 - 122
161	X-RAY DIFFRACTION	161	( CHAIN Z AND RESID 123:132 )	Z	123 - 132
162	X-RAY DIFFRACTION	162	( CHAIN Z AND RESID 133:158 )	Z	133 - 158
163	X-RAY DIFFRACTION	163	( CHAIN Z AND RESID 159:169 )	Z	159 - 169
164	X-RAY DIFFRACTION	164	( CHAIN Z AND RESID 170:183 )	Z	170 - 183
165	X-RAY DIFFRACTION	165	( CHAIN Z AND RESID 184:191 )	Z	184 - 191
166	X-RAY DIFFRACTION	166	( CHAIN a AND RESID 15:25 )	a	15 - 25
167	X-RAY DIFFRACTION	167	( CHAIN a AND RESID 26:82 )	a	26 - 82
168	X-RAY DIFFRACTION	168	( CHAIN a AND RESID 83:134 )	a	83 - 134
169	X-RAY DIFFRACTION	169	( CHAIN a AND RESID 135:172 )	a	135 - 172
170	X-RAY DIFFRACTION	170	( CHAIN a AND RESID 173:207 )	a	173 - 207
171	X-RAY DIFFRACTION	171	( CHAIN b AND RESID 16:26 )	b	16 - 26
172	X-RAY DIFFRACTION	172	( CHAIN b AND RESID 27:54 )	b	27 - 54
173	X-RAY DIFFRACTION	173	( CHAIN b AND RESID 55:104 )	b	55 - 104
174	X-RAY DIFFRACTION	174	( CHAIN b AND RESID 105:122 )	b	105 - 122
175	X-RAY DIFFRACTION	175	( CHAIN b AND RESID 123:158 )	b	123 - 158
176	X-RAY DIFFRACTION	176	( CHAIN b AND RESID 159:169 )	b	159 - 169
177	X-RAY DIFFRACTION	177	( CHAIN b AND RESID 170:191 )	b	170 - 191