登録情報 | データベース: PDB / ID: 7x3p |
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タイトル | Crystal structure of human SIRT5 in complex with diazirine inhibitor 9 |
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要素 | NAD-dependent protein deacylase sirtuin-5, mitochondrial |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / inhibitor / complex / hydrolase / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
protein demalonylation / protein deglutarylation / regulation of ketone biosynthetic process / peptidyl-lysine demalonylation / protein desuccinylation / peptidyl-lysine desuccinylation / protein-glutaryllysine deglutarylase activity / protein-malonyllysine demalonylase activity / protein-succinyllysine desuccinylase activity / NAD-dependent protein lysine deacetylase activity ...protein demalonylation / protein deglutarylation / regulation of ketone biosynthetic process / peptidyl-lysine demalonylation / protein desuccinylation / peptidyl-lysine desuccinylation / protein-glutaryllysine deglutarylase activity / protein-malonyllysine demalonylase activity / protein-succinyllysine desuccinylase activity / NAD-dependent protein lysine deacetylase activity / protein deacetylation / NAD-dependent histone deacetylase activity / negative regulation of cardiac muscle cell apoptotic process / NAD+ binding / negative regulation of reactive oxygen species metabolic process / 転移酵素; アシル基を移すもの; アミノアシル基以外のアシル基を移すもの / mitochondrion organization / response to nutrient levels / Transcriptional activation of mitochondrial biogenesis / mitochondrial intermembrane space / transferase activity / mitochondrial matrix / mitochondrion / zinc ion binding / nucleus / cytosol類似検索 - 分子機能 Sirtuin, class III / Sirtuin, catalytic core small domain superfamily / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / DHS-like NAD/FAD-binding domain superfamily類似検索 - ドメイン・相同性 Chem-8VG / DI(HYDROXYETHYL)ETHER / NAD-dependent protein deacylase sirtuin-5, mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.56 Å |
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データ登録者 | Li, G.-B. / Deng, J. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | 82122065, 82073698 | 中国 |
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引用 | ジャーナル: To Be Published タイトル: Crystal structure of human SIRT5 in complex with diazirine inhibitor 9 著者: Li, G.-B. / Deng, J. |
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履歴 | 登録 | 2022年3月1日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2023年9月6日 | Provider: repository / タイプ: Initial release |
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