Entry | Database: PDB / ID: 7wm3 |
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Title | hnRNP A2/B1 RRMs in complex with single-stranded DNA |
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Components | - DNA (5'-D(P*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3')
- Heterogeneous nuclear ribonucleoproteins A2/B1
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Keywords | DNA BINDING PROTEIN/DNA / homodimerization / U-shaped structured DNA / DNA BINDING PROTEIN-DNA COMPLEX |
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Function / homology | Function and homology information
: / miRNA transport / positive regulation of telomere maintenance via telomere lengthening / RNA transport / G-quadruplex DNA unwinding / primary miRNA processing / single-stranded telomeric DNA binding / N6-methyladenosine-containing RNA reader activity / G-rich strand telomeric DNA binding / miRNA binding ...: / miRNA transport / positive regulation of telomere maintenance via telomere lengthening / RNA transport / G-quadruplex DNA unwinding / primary miRNA processing / single-stranded telomeric DNA binding / N6-methyladenosine-containing RNA reader activity / G-rich strand telomeric DNA binding / miRNA binding / negative regulation of mRNA splicing, via spliceosome / Processing of Capped Intron-Containing Pre-mRNA / mRNA transport / mRNA export from nucleus / Cajal body / pre-mRNA intronic binding / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / catalytic step 2 spliceosome / mRNA Splicing - Major Pathway / molecular condensate scaffold activity / mRNA 3'-UTR binding / spliceosomal complex / nuclear matrix / mRNA splicing, via spliceosome / mRNA processing / chromosome, telomeric region / ribonucleoprotein complex / negative regulation of transcription by RNA polymerase II / RNA binding / extracellular exosome / nucleoplasm / identical protein binding / membrane / nucleus / cytoplasmSimilarity search - Function hnRNP A2/B1, RNA recognition motif 1 / Heterogeneous nuclear ribonucleoprotein A1/A2, C-terminal / Heterogeneous nuclear ribonucleoprotein A1, LC domain / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Nucleotide-binding alpha-beta plait domain superfamilySimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.62 Å |
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Authors | Abula, A. / Liu, Y. / Guo, H. / Li, T. / Ji, X. |
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Funding support | 1items Organization | Grant number | Country |
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Not funded | | |
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Citation | Journal: J.Mol.Biol. / Year: 2022 Title: Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition. Authors: Liu, Y. / Abula, A. / Xiao, H. / Guo, H. / Li, T. / Zheng, L. / Chen, B. / Nguyen, H.C. / Ji, X. |
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History | Deposition | Jan 14, 2022 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Jun 29, 2022 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jan 4, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.2 | Jan 11, 2023 | Group: Database references / Category: citation / Item: _citation.journal_volume / _citation.title |
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Revision 1.3 | Nov 29, 2023 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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