登録情報 | データベース: PDB / ID: 7wgn |
---|
タイトル | X-ray structure of human PPAR delta ligand binding domain-pemafibrate co-crystals obtained by co-crystallization |
---|
要素 | Peroxisome proliferator-activated receptor delta |
---|
キーワード | TRANSCRIPTION (転写 (生物学)) / Nuclear receptor (核内受容体) / Protein-ligand complex / PPAR (PPAR) |
---|
機能・相同性 | 機能・相同性情報
fat cell proliferation / positive regulation of fat cell proliferation / keratinocyte migration / linoleic acid binding / positive regulation of skeletal muscle tissue regeneration / axon ensheathment / regulation of skeletal muscle satellite cell proliferation / glucose transmembrane transport / positive regulation of myoblast proliferation / fatty acid catabolic process ...fat cell proliferation / positive regulation of fat cell proliferation / keratinocyte migration / linoleic acid binding / positive regulation of skeletal muscle tissue regeneration / axon ensheathment / regulation of skeletal muscle satellite cell proliferation / glucose transmembrane transport / positive regulation of myoblast proliferation / fatty acid catabolic process / Carnitine metabolism / negative regulation of myoblast differentiation / Regulation of pyruvate dehydrogenase (PDH) complex / Signaling by Retinoic Acid / nuclear steroid receptor activity / positive regulation of fatty acid metabolic process / fatty acid beta-oxidation / cell-substrate adhesion / negative regulation of cholesterol storage / cellular response to nutrient levels / decidualization / keratinocyte proliferation / fatty acid transport / positive regulation of fat cell differentiation / adipose tissue development / energy homeostasis / 着床 / cholesterol metabolic process / hormone-mediated signaling pathway / negative regulation of miRNA transcription / phosphatidylinositol 3-kinase/protein kinase B signal transduction / fatty acid metabolic process / generation of precursor metabolites and energy / apoptotic signaling pathway / wound healing / lipid metabolic process / transcription coactivator binding / DNA-binding transcription repressor activity, RNA polymerase II-specific / negative regulation of inflammatory response / Nuclear Receptor transcription pathway / glucose metabolic process / nuclear receptor activity / negative regulation of epithelial cell proliferation / sequence-specific double-stranded DNA binding / cellular response to hypoxia / DNA-binding transcription factor binding / cell population proliferation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / 細胞分化 / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / lipid binding / apoptotic process / クロマチン / positive regulation of gene expression / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / 核質 / 細胞核類似検索 - 分子機能 Peroxisome proliferator-activated receptor, beta / PPAR / 核内受容体 / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily ...Peroxisome proliferator-activated receptor, beta / PPAR / 核内受容体 / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type類似検索 - ドメイン・相同性 Chem-P7F / Peroxisome proliferator-activated receptor delta類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.813 Å |
---|
データ登録者 | Kamata, S. / Honda, A. / Akahane, M. / Machida, Y. / Uchii, K. / Shiiyama, Y. / Masuda, R. / Oyama, T. / Ishii, I. |
---|
資金援助 | 日本, 2件 組織 | 認可番号 | 国 |
---|
Japan Society for the Promotion of Science (JSPS) | 19K16359 | 日本 | Japan Agency for Medical Research and Development (AMED) | JP19am0101071 | 日本 |
|
---|
引用 | ジャーナル: Int J Mol Sci / 年: 2022 タイトル: Functional and Structural Insights into Human PPAR alpha / delta / gamma Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate. 著者: Honda, A. / Kamata, S. / Akahane, M. / Machida, Y. / Uchii, K. / Shiiyama, Y. / Habu, Y. / Miyawaki, S. / Kaneko, C. / Oyama, T. / Ishii, I. |
---|
履歴 | 登録 | 2021年12月28日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
---|
改定 1.0 | 2022年5月25日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
---|
|
---|