登録情報 データベース : PDB / ID : 7vsl 構造の表示 ダウンロードとリンクタイトル Crystal structure of PDE8A catalytic domain in complex with 10 要素High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 詳細 キーワード HYDROLASE / cAMP-specific / Selective PDE8A inhibitor機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
3',5'-cyclic-AMP phosphodiesterase / protein kinase activator activity / cAMP catabolic process / cellular response to epidermal growth factor stimulus / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / cAMP-mediated signaling / kinase binding / G alpha (s) signalling events / positive regulation of ERK1 and ERK2 cascade ... 3',5'-cyclic-AMP phosphodiesterase / protein kinase activator activity / cAMP catabolic process / cellular response to epidermal growth factor stimulus / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / cAMP-mediated signaling / kinase binding / G alpha (s) signalling events / positive regulation of ERK1 and ERK2 cascade / regulation of DNA-templated transcription / perinuclear region of cytoplasm / extracellular exosome / nucleus / metal ion binding / cytosol 類似検索 - 分子機能 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domain / PAS fold ... 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domain / PAS fold / PAS fold / PAS repeat profile. / PAS domain / PAS domain superfamily 類似検索 - ドメイン・相同性 Chem-7XI / High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.50006900162 Å 詳細データ登録者 Wu, X.-N. / Zhou, Q. / Huang, Y.-D. / Li, Z. / Wu, Y. / Luo, H.-B. 資金援助 中国, 2件 詳細 詳細を隠す組織 認可番号 国 National Natural Science Foundation of China (NSFC) 21877134 中国 National Natural Science Foundation of China (NSFC) 22077143 中国
引用ジャーナル : To Be Published タイトル : Structure-Based Discovery of Orally Efficient PDE8 Inhibitors for the Treatment of Vascular Dementia著者 : Wu, X.-N. / Zhou, Q. / Huang, Y.-D. / Li, Z. / Wu, Y. / Luo, H.-B. 履歴 登録 2021年10月26日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2022年11月2日 Provider : repository / タイプ : Initial release改定 1.1 2023年11月29日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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