PDB-7uvf: Crystal structure of ZED8 Fab complex with CD8 alpha

ID or keywords:

Entry

Database: PDB / ID: 7uvf

Title

Crystal structure of ZED8 Fab complex with CD8 alpha

Components

(Immunoglobulin ...) x 2
T-cell surface glycoprotein CD8 alpha chain

Keywords

IMMUNE SYSTEM / imaging / cd8

Function / homology

Function and homology information

cytotoxic T cell differentiation / MHC class I protein complex binding / T cell mediated immunity / T cell receptor complex / MHC class I protein binding / plasma membrane raft / antigen processing and presentation / coreceptor activity / cell surface receptor protein tyrosine kinase signaling pathway / T cell activation ...
Similarity search - Function

Biological species

Homo sapiens (human)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 2.6 Å

Authors

Yu, C. / Davies, C. / Koerber, J.T. / Williams, S.

Funding support

1items

Citation

Journal: Eur J Nucl Med Mol Imaging / Year: 2023
Title: Preclinical development of ZED8, an 89 Zr immuno-PET reagent for monitoring tumor CD8 status in patients undergoing cancer immunotherapy.
Authors: Ogasawara, A. / Kiefer, J.R. / Gill, H. / Chiang, E. / Sriraman, S. / Ferl, G.Z. / Ziai, J. / Bohorquez, S.S. / Guelman, S. / Wang, X. / Yang, J. / Phan, M.M. / Nguyen, V. / Chung, S. / Yu, ...

History

Deposition	May 1, 2022	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Oct 12, 2022	Provider: repository / Type: Initial release
Revision 1.1	Nov 9, 2022	Group: Database references / Category: citation / citation_author Item: _citation.journal_abbrev / _citation.journal_id_CSD ..._citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year
Revision 1.2	Jan 18, 2023	Group: Database references / Category: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year
Revision 1.3	Apr 3, 2024	Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	7uvf.cif.gz	435.2 KB	Display	PDBx/mmCIF format
PDB format	pdb7uvf.ent.gz	358.8 KB	Display	PDB format
PDBx/mmJSON format	7uvf.json.gz		Tree view	PDBx/mmJSON format
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Validation report

Summary document	7uvf_validation.pdf.gz	484.7 KB	Display	wwPDB validaton report
Full document	7uvf_full_validation.pdf.gz	500.8 KB	Display
Data in XML	7uvf_validation.xml.gz	40.7 KB	Display
Data in CIF	7uvf_validation.cif.gz	57.3 KB	Display
Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/uv/7uvf ftp://data.pdbj.org/pub/pdb/validation_reports/uv/7uvf	HTTPS FTP

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Related structure data

Similar structure data	Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#63 - Mar 2005 T-Cell Receptor similarity (2) #21 - Sep 2001 Antibodies similarity (1) #256 - Apr 2021 SARS-CoV-2 Spike and Antibodies similarity (1)

Deposited unit

A: T-cell surface glycoprotein CD8 alpha chain

B: T-cell surface glycoprotein CD8 alpha chain

H: Immunoglobulin heavy chain

L: Immunoglobulin light chain

Y: Immunoglobulin light chain

X: Immunoglobulin heavy chain

hetero molecules

123 kDa, 6 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

Idetical with deposited unit
defined by author
Evidence: gel filtration

Unit cell

Length a, b, c (Å)	268.968, 59.441, 111.377
Angle α, β, γ (deg.)	90.000, 112.290, 90.000
Int Tables number	5
Space group name H-M	C121

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Protein , 1 types, 2 molecules AB

#1: Protein	T-cell surface glycoprotein CD8 alpha chain / T-lymphocyte differentiation antigen T8/Leu-2 Mass: 14425.239 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: CD8A, MAL / Production host: Escherichia coli (E. coli) / References: UniProt: P01732

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Antibody , 2 types, 4 molecules HXLY

#2: Antibody	Immunoglobulin heavy chain Mass: 23474.221 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli)
#3: Antibody	Immunoglobulin light chain Mass: 23437.936 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli)

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Non-polymers , 3 types, 175 molecules

#4: Chemical	ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL Mass: 92.094 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C₃H₈O₃
#5: Chemical	ChemComp-CL / CHLORIDE ION Mass: 35.453 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: Cl
#6: Water	ChemComp-HOH / water Mass: 18.015 Da / Num. of mol.: 172 / Source method: isolated from a natural source / Formula: H₂O

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Details

Has ligand of interest	N

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 3.36 Å³/Da / Density % sol: 63.37 %
Crystal grow	Temperature: 292 K / Method: vapor diffusion / pH: 6 Details: 0.1M ammonium acetate 0.1M Bis-Tris pH6.0 17% PEG 10K

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Data collection

Diffraction

Mean temperature: 93 K / Serial crystal experiment: N

Diffraction source

Source:

SYNCHROTRON / Site:

SSRL

/ Beamline: BL12-2 / Wavelength: 0.9795 Å

Detector

Type: DECTRIS PILATUS 6M / Detector: PIXEL / Date: May 27, 2015

Radiation

Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray

Radiation wavelength

Wavelength: 0.9795 Å / Relative weight: 1

Reflection

Resolution: 2.6→40 Å / Num. obs: 48140 / % possible obs: 94.7 % / Redundancy: 3.1 % / R_merge(I) obs: 0.076 / R_pim(I) all: 0.05 / R_rim(I) all: 0.089 / Χ²: 1.002 / Net I/σ(I): 8.4 / Num. measured all: 151360

Reflection shell

Diffraction-ID: 1

Resolution (Å)	Redundancy (%)	R_merge(I) obs	Num. unique obs	CC_1/2	R_pim(I) all	Χ²	% possible all	R_rim(I) all
2.6-2.64	1.9	0.838	1947	0.442	0.675	0.854	78.4
2.64-2.69	2.2	0.831	2189	0.399	0.634	0.925	85.9
2.69-2.74	2.4	0.782	2290	0.505	0.575	0.927	91.9	0.977
2.74-2.8	2.6	0.629	2266	0.585	0.456	0.941	90.2	0.781
2.8-2.86	3	0.589	2343	0.714	0.4	0.95	92.5	0.716
2.86-2.93	3.3	0.451	2460	0.79	0.287	0.975	98.5	0.537
2.93-3	3.4	0.366	2514	0.846	0.231	0.941	98.2	0.435
3-3.08	3.4	0.299	2478	0.889	0.191	0.949	98.7	0.357
3.08-3.17	3.4	0.233	2480	0.94	0.148	0.958	98	0.277
3.17-3.28	3.3	0.195	2458	0.955	0.126	0.992	97.3	0.233
3.28-3.39	3.2	0.151	2443	0.973	0.099	1.01	97.3	0.181
3.39-3.53	3.3	0.107	2301	0.984	0.07	1.052	90.3	0.128
3.53-3.69	3.5	0.099	2489	0.986	0.062	1.244	98.3	0.117
3.69-3.88	3.4	0.078	2475	0.992	0.049	1.056	98.1	0.092
3.88-4.13	3.4	0.058	2518	0.996	0.037	0.991	98.6	0.069
4.13-4.44	3.3	0.045	2508	0.997	0.029	1.02	98.2	0.054
4.44-4.89	3.4	0.037	2404	0.998	0.024	1.033	93.5	0.044
4.89-5.6	3.5	0.036	2534	0.998	0.022	0.95	99.3	0.043
5.6-7.05	3.2	0.037	2456	0.997	0.024	0.989	94.8	0.045
7.05-40	3.4	0.026	2587	0.999	0.017	1.054	96.7	0.032

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Processing

Software

Name	Version	Classification
HKL-2000		data reduction
SCALEPACK		data scaling
PHENIX	1.16	refinement
PDB_EXTRACT	3.27	data extraction
PHASER		phasing

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT
Starting model: Internal

Resolution: 2.6→34.3545 Å / SU ML: 0.39 / Cross valid method: THROUGHOUT / σ(F): 1.34 / Phase error: 28.22 / Stereochemistry target values: ML

	R_factor	Num. reflection	% reflection
R_free	0.2587	2430	5.05 %
R_work	0.1978	45698	-
obs	0.2008	48128	94.63 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL

Displacement parameters

B_iso max: 164.14 Å² / B_iso mean: 76.7955 Å² / B_iso min: 30.39 Å²

Refinement step

Cycle: final / Resolution: 2.6→34.3545 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	8170	0	8	172	8350
B_iso mean	-	-	63.99	53.29	-
Num. residues	-	-	-	-	1078

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.008	8394
X-RAY DIFFRACTION	f_angle_d	1.014	11450
X-RAY DIFFRACTION	f_dihedral_angle_d	6.275	5389
X-RAY DIFFRACTION	f_chiral_restr	0.056	1300
X-RAY DIFFRACTION	f_plane_restr	0.007	1479

LS refinement shell

Refine-ID: X-RAY DIFFRACTION / R_factor R_free error: 0

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	% reflection obs (%)
2.6-2.6494	0.3862	110	0.3539	2175	77
2.6494-2.707	0.3731	129	0.3206	2451	87
2.707-2.77	0.3397	139	0.2894	2608	94
2.77-2.8392	0.3154	141	0.2649	2519	89
2.8392-2.9159	0.3086	161	0.2552	2739	99
2.9159-3.0017	0.3042	157	0.2567	2790	98
3.0017-3.0985	0.3258	140	0.2497	2770	98
3.0985-3.2092	0.3023	145	0.2335	2748	98
3.2092-3.3376	0.342	147	0.2353	2774	97
3.3376-3.4893	0.2671	125	0.2182	2597	91
3.4893-3.6731	0.3401	136	0.2153	2758	98
3.6731-3.9029	0.2603	170	0.1952	2785	98
3.9029-4.2038	0.2368	146	0.1691	2809	99
4.2038-4.6259	0.1885	126	0.1457	2689	94
4.6259-5.2932	0.2017	153	0.1414	2855	99
5.2932-6.6609	0.2338	147	0.1793	2802	97
6.6609-34.3545	0.2073	158	0.1778	2829	95

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	3.5291	0.1604	0.7358	2.4943	1.3223	0.9362	0.1006	0.2778	0.0345	0.0615	-0.3643	0.2077	-0.3305	0.1221	0.0005	0.5004	-0.002	0.0364	0.3603	-0.0289	0.3991	-72.308	35.635	51.66
2	1.7958	-0.3992	0.1335	2.4345	-0.9689	1.6202	0.0561	0.2617	0.0106	0.0059	-0.0622	-0.4062	-0.3426	0.2358	-0.0003	0.5139	0.0076	0.0377	0.3806	-0.066	0.4469	-67.11	36.92	51.359
3	3.099	0.2077	1.8484	2.328	-0.2316	1.2013	0.2178	0.6068	0.3711	-0.3745	0.0214	-0.5499	-0.409	0.1993	-0.0001	0.6252	-0.0645	0.1033	0.3803	-0.0143	0.5461	-69.911	61.427	59.618
4	3.2441	-0.756	1.2422	2.8886	2.1025	2.6695	-0.04	0.5265	0.1435	-0.2539	0.2259	0.3913	-0.3651	-0.5487	0.0009	0.7017	-0.0259	0.04	0.4009	0.048	0.5241	-79.05	56.882	53.06
5	3.3475	-0.8793	0.9175	1.9717	1.2035	1.4333	0.0751	0.1341	-0.0456	-0.4538	-0.0245	-0.2206	-0.2787	-0.0917	0.0003	0.5793	-0.054	0.0635	0.2475	0.0141	0.4413	-74.223	55.792	61.02
6	0.8345	0.3109	0.4274	1.2176	-0.74	0.948	-0.2848	-0.6307	-0.5202	-0.0433	0.1204	0.154	0.3295	0.3868	-0.0137	0.6412	0.074	-0.0538	0.533	0.0208	0.6818	-55.251	4.177	80.002
7	1.2386	0.197	0.4934	3.9757	-0.434	3.0208	-0.1327	0.0015	-0.3242	0.0702	-0.1176	-0.3514	0.0072	0.2863	-0.0001	0.4122	0.012	-0.0025	0.3402	-0.0001	0.463	-60.478	12.987	72.609
8	0.9763	0.0473	0.8032	1.076	0.3648	0.7572	-0.2814	0.2417	-0.358	0.0883	0.2179	-0.0636	0.6387	-0.0323	0.0003	0.5108	0.0548	0.0446	0.52	-0.0233	0.5643	-63.056	5.744	71.791
9	0.3906	0.3205	0.189	0.8567	-0.4013	0.609	0.7396	0.1277	-0.2921	-0.9283	-0.4791	-0.5903	-0.5841	0.3462	-0.0007	0.509	0.0693	-0.0226	0.5222	0.0762	0.7334	-51.005	8.281	73.214
10	0.9898	0.7692	0.5087	0.6211	0.3276	2.4365	-0.0655	-0.3145	-0.1316	0.4522	-0.2726	-0.4837	0.0305	0.4598	-0.0006	0.4892	-0.0182	0.0303	0.5572	0.1027	0.6789	-52.947	10.575	78.439
11	0.0031	-0.0432	0.0444	0.2859	-0.2803	0.273	-0.5156	-0.2639	-0.9135	0.4563	0.3923	0.1148	-0.6974	0.6035	-0.0003	0.9134	0.1184	-0.1696	1.2505	0.1164	0.9814	-27.583	0.128	94.914
12	0.615	0.0487	0.0594	2.0297	-0.3645	0.1293	-0.0037	-0.3078	-0.0477	0.5643	-1.0174	-0.186	-0.1147	0.8089	0	0.7408	-0.1382	-0.1455	1.3717	0.2042	0.9692	-32.99	3.754	96.504
13	0.0996	-0.0645	-0.13	0.0819	0.1637	0.2806	-0.0919	-0.4492	0.1138	0.4828	-0.4365	0.1661	0.2503	0.3572	-0.0027	0.8574	-0.0911	-0.1008	1.1338	0.1455	0.9336	-34.912	-4.831	98.394
14	2.0568	-0.5888	1.9456	1.854	-1.1743	2.4134	-0.2463	-0.3	0.4802	0.6027	-0.2847	-0.627	-0.6817	0.3441	-0.0015	0.7227	-0.1617	-0.2118	0.576	-0.0191	0.7822	-49.68	30.06	79.082
15	0.191	0.1995	-0.155	0.2776	-0.3081	0.4318	-0.479	-1.0286	0.3886	0.5445	-0.446	-0.8471	-0.4847	0.1842	-0.2063	0.9402	-0.3793	-0.5717	1.2911	0.3424	1.0537	-31.715	24.794	92.839
16	2.0831	1.3535	0.3165	1.6141	-0.5944	1.1602	-0.1395	0.4832	-0.0606	0.2303	-0.3017	-0.7047	-0.1061	1.0072	0.0002	0.7159	-0.0411	-0.1399	1.6099	0.38	1.1976	-23.254	8.639	88.931
17	0.1192	-0.4409	-0.1334	1.7109	0.4841	0.1846	-0.1388	0.2472	0.3027	-0.473	0.1613	-1.2867	-0.3495	0.7628	0.025	0.6558	-0.1152	-0.1863	1.5033	0.4075	1.8659	-13.646	12.393	90.495
18	0.3614	-0.4601	0.3295	0.9346	0.0172	0.8444	0.2181	-0.3065	-1.1784	0.3183	-0.2839	0.2295	-0.1208	-0.5582	-0.0297	0.598	-0.2195	0.0284	0.6798	0.1816	0.8908	-109.058	46.42	75.075
19	0.7723	0.4005	-0.0272	0.673	-0.3491	0.5157	0.1479	-0.7146	-0.811	-0.2182	-0.0708	0.2061	0.1777	-0.3016	0.0015	0.6314	-0.108	-0.0007	0.526	0.1564	0.5642	-99.766	49.221	72.209
20	0.3187	-0.1091	0.1153	0.6087	0.4485	0.4527	-0.1169	-1.3382	-1.1155	-0.4569	-0.3142	0.0414	0.2125	0.0714	-0.1297	0.7751	-0.072	0.1892	0.9911	0.5124	0.8617	-96.729	43.587	83.456
21	0.37	-0.0894	0.3167	0.6681	0.1475	0.3517	-0.2605	-0.65	-1.2487	0.0749	0.2776	0.434	0.752	-0.5127	0.0338	0.7745	-0.173	0.0428	0.727	0.37	0.925	-102.891	43.198	77.352
22	0.1014	-0.0007	0.1757	0.2899	-0.0194	0.317	-0.2374	0.1528	0.1115	-0.355	0.4992	0.4338	0.4971	-0.7699	0.0006	0.5274	-0.059	-0.012	0.5444	0.075	0.4464	-97.882	57.416	73.868
23	1.7599	0.3794	-0.3002	0.6425	-0.3731	0.2199	0.032	-0.6613	-0.0128	0.042	0.0158	0.5122	0.2634	-0.3128	0.1625	0.6447	-0.4517	0.0709	1.1658	0.623	1.2205	-122.641	42.556	84.834
24	1.7817	0.7104	0.3858	1.1432	-0.4083	1.5859	-0.4269	-0.9016	0.1924	-0.1944	0.0597	0.5032	-0.0575	-0.5113	-0.2561	0.6365	-0.2579	-0.0293	1.7913	0.622	0.9419	-133.196	59.456	91.379
25	0.2152	0.4988	0.5658	1.1767	1.3307	1.5165	-0.1356	-0.2359	0.2951	-0.9264	-0.3158	0.3059	0.2596	-0.9802	-0.1475	0.6754	-0.182	-0.105	1.4956	0.4951	0.8479	-133.402	64.423	83.857
26	0.2272	0.2543	-0.4072	0.2874	-0.5024	1.3623	-0.4865	-0.3701	-0.3565	0.2235	0.0273	0.2321	0.9113	0.2496	0.1316	0.7407	-0.2497	0.1343	1.3754	0.8569	1.1102	-120.79	45.779	91.02
27	0.042	0.0087	0.013	0.292	-0.0973	0.3008	-0.1815	-0.1309	0.6543	-0.2645	-0.1802	0.494	-0.0032	0.1527	0.005	0.4488	-0.0497	-0.1385	1.6076	0.3512	1.1952	-137.106	69.209	90.509
28	0.1573	-0.0909	0.0164	0.2888	-0.2743	0.295	0.0103	0.3309	0.2123	-0.1496	0.0761	0.1548	0.1282	-0.558	-0.0011	0.5606	-0.0984	-0.1204	1.5894	0.3937	1.2653	-140.57	55.608	87.139
29	1.2573	-0.8579	-0.0684	1.3772	-0.158	0.8918	0.241	-1.1503	-0.0815	-0.5922	0.0227	0.0647	-0.0573	0.1609	0.1256	0.5915	0.0756	0.2705	1.4558	-0.1834	0.3643	-98.921	64.912	95.231
30	2.6509	0.5667	-0.941	0.1773	-0.1367	0.4624	0.0884	-1.7073	-0.2071	0.5731	-0.0978	-0.2598	0.3068	0.2135	0.1689	0.5831	-0.1108	-0.0368	1.5371	-0.0211	0.2602	-89.976	61.34	90.248
31	0.1366	0.1832	-0.3616	1.3094	-0.4565	0.9525	0.2003	-1.1383	0.6508	-0.0838	-0.2467	0.4541	0.0149	-0.3985	-0.0005	0.4726	-0.1028	-0.0411	0.7681	-0.0903	0.4746	-97.258	62.87	81.618
32	0.779	0.683	0.0044	1.2004	0.6678	0.7172	0.118	-1.3782	0.4348	0.088	0.0654	-0.259	-0.3516	0.1759	0.0107	0.5554	-0.0598	0.0391	1.1139	-0.1855	0.4475	-88.657	68.856	86.692
33	1.8679	0.9457	-0.3251	0.7446	0.3694	1.2303	0.0663	-1.5639	-0.0921	0.0764	0.0227	0.1539	-0.0204	-0.1262	0.0012	0.529	-0.0633	0.0097	0.9869	0.0792	0.4287	-96.353	60.761	85.635
34	2.608	-0.7755	-1.4312	0.6328	0.336	0.794	-0.7507	-1.127	0.6466	0.4201	0.308	0.2157	0.2977	-0.9824	-0.2006	0.487	-0.0019	0.2411	1.5197	-0.2234	0.5136	-111.42	72.501	95.737
35	0.4418	0.2702	-0.4511	0.7156	0.0813	0.7852	-0.5509	-1.0991	-0.0243	-0.9471	0.4691	0.5502	0.1242	0.2052	-0.0478	0.6074	0.029	-0.0216	1.9717	0.334	0.7776	-130.592	61.014	101.074
36	0.8663	-0.1996	-0.1822	1.6422	0.0696	0.9137	-0.1442	-1.6067	-0.5912	0.1983	0.5577	0.376	0.1882	-0.1499	-0.0819	0.3444	-0.0811	0.2516	2.3386	0.7754	0.7691	-124.115	57.589	101.828
37	5.1393	1.9602	-2.0777	1.3688	-0.2481	1.341	-0.1078	-1.3439	0.1235	0.6251	0.4605	0.6657	0.166	0.0328	0.9521	0.3711	0.0749	0.2785	2.205	0.0821	0.8758	-122.522	64.668	108.657

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	( CHAIN A AND RESID 1:46 )	A	1 - 46
2	X-RAY DIFFRACTION	2	( CHAIN A AND RESID 47:117 )	A	47 - 117
3	X-RAY DIFFRACTION	3	( CHAIN B AND RESID 1:32 )	B	1 - 32
4	X-RAY DIFFRACTION	4	( CHAIN B AND RESID 33:73 )	B	33 - 73
5	X-RAY DIFFRACTION	5	( CHAIN B AND RESID 74:117 )	B	74 - 117
6	X-RAY DIFFRACTION	6	( CHAIN H AND RESID 1:17 )	H	1 - 17
7	X-RAY DIFFRACTION	7	( CHAIN H AND RESID 18:63 )	H	18 - 63
8	X-RAY DIFFRACTION	8	( CHAIN H AND RESID 64:82 )	H	64 - 82
9	X-RAY DIFFRACTION	9	( CHAIN H AND RESID 83:95 )	H	83 - 95
10	X-RAY DIFFRACTION	10	( CHAIN H AND RESID 97:119 )	H	97 - 119
11	X-RAY DIFFRACTION	11	( CHAIN H AND RESID 120:145 )	H	120 - 145
12	X-RAY DIFFRACTION	12	( CHAIN H AND RESID 146:193 )	H	146 - 193
13	X-RAY DIFFRACTION	13	( CHAIN H AND RESID 194:213 )	H	194 - 213
14	X-RAY DIFFRACTION	14	( CHAIN L AND RESID 1:101 )	L	1 - 101
15	X-RAY DIFFRACTION	15	( CHAIN L AND RESID 102:115 )	L	102 - 115
16	X-RAY DIFFRACTION	16	( CHAIN L AND RESID 116:187 )	L	116 - 187
17	X-RAY DIFFRACTION	17	( CHAIN L AND RESID 188:211 )	L	188 - 211
18	X-RAY DIFFRACTION	18	( CHAIN Y AND RESID 1:18 )	Y	1 - 18
19	X-RAY DIFFRACTION	19	( CHAIN Y AND RESID 19:38 )	Y	19 - 38
20	X-RAY DIFFRACTION	20	( CHAIN Y AND RESID 39:61 )	Y	39 - 61
21	X-RAY DIFFRACTION	21	( CHAIN Y AND RESID 62:90 )	Y	62 - 90
22	X-RAY DIFFRACTION	22	( CHAIN Y AND RESID 91:102 )	Y	91 - 102
23	X-RAY DIFFRACTION	23	( CHAIN Y AND RESID 103:114 )	Y	103 - 114
24	X-RAY DIFFRACTION	24	( CHAIN Y AND RESID 115:150 )	Y	115 - 150
25	X-RAY DIFFRACTION	25	( CHAIN Y AND RESID 151:163 )	Y	151 - 163
26	X-RAY DIFFRACTION	26	( CHAIN Y AND RESID 164:174 )	Y	164 - 174
27	X-RAY DIFFRACTION	27	( CHAIN Y AND RESID 175:190 )	Y	175 - 190
28	X-RAY DIFFRACTION	28	( CHAIN Y AND RESID 191:213 )	Y	191 - 213
29	X-RAY DIFFRACTION	29	( CHAIN X AND RESID 1:16 )	X	1 - 16
30	X-RAY DIFFRACTION	30	( CHAIN X AND RESID 17:39 )	X	17 - 39
31	X-RAY DIFFRACTION	31	( CHAIN X AND RESID 40:52 )	X	40 - 52
32	X-RAY DIFFRACTION	32	( CHAIN X AND RESID 53:82 )	X	53 - 82
33	X-RAY DIFFRACTION	33	( CHAIN X AND RESID 83:106 )	X	83 - 106
34	X-RAY DIFFRACTION	34	( CHAIN X AND RESID 107:118 )	X	107 - 118
35	X-RAY DIFFRACTION	35	( CHAIN X AND RESID 120:145 )	X	120 - 145
36	X-RAY DIFFRACTION	36	( CHAIN X AND RESID 146:199 )	X	146 - 199
37	X-RAY DIFFRACTION	37	( CHAIN X AND RESID 200:213 )	X	200 - 213

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