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TitlePreclinical development of ZED8, an 89 Zr immuno-PET reagent for monitoring tumor CD8 status in patients undergoing cancer immunotherapy.
Journal, issue, pagesEur J Nucl Med Mol Imaging, Vol. 50, Page 287-301, Year 2023
Publish dateMay 1, 2022 (structure data deposition date)
AuthorsOgasawara, A. / Kiefer, J.R. / Gill, H. / Chiang, E. / Sriraman, S. / Ferl, G.Z. / Ziai, J. / Bohorquez, S.S. / Guelman, S. / Wang, X. ...Ogasawara, A. / Kiefer, J.R. / Gill, H. / Chiang, E. / Sriraman, S. / Ferl, G.Z. / Ziai, J. / Bohorquez, S.S. / Guelman, S. / Wang, X. / Yang, J. / Phan, M.M. / Nguyen, V. / Chung, S. / Yu, C. / Tinianow, J. / Waaijer, S.J.H. / De Crespigny, A. / Marik, J. / Boswell, C.A. / Zabka, T. / Staflin, K. / Williams, S.P.
External linksEur J Nucl Med Mol Imaging / PubMed:36271158
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-7uvf:
Crystal structure of ZED8 Fab complex with CD8 alpha
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / imaging / cd8

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