登録情報 | データベース: PDB / ID: 7u4i |
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タイトル | Crystal structure of human GPX4-U46C-R152H in complex with CDS9 |
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要素 | Phospholipid hydroperoxide glutathione peroxidase |
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キーワード | OXIDOREDUCTASE / GPX4 |
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機能・相同性 | 機能・相同性情報
phospholipid-hydroperoxide glutathione peroxidase / phospholipid-hydroperoxide glutathione peroxidase activity / Synthesis of 15-eicosatetraenoic acid derivatives / Synthesis of 12-eicosatetraenoic acid derivatives / selenium binding / Synthesis of 5-eicosatetraenoic acids / glutathione peroxidase / lipoxygenase pathway / Biosynthesis of aspirin-triggered D-series resolvins / Biosynthesis of E-series 18(R)-resolvins ...phospholipid-hydroperoxide glutathione peroxidase / phospholipid-hydroperoxide glutathione peroxidase activity / Synthesis of 15-eicosatetraenoic acid derivatives / Synthesis of 12-eicosatetraenoic acid derivatives / selenium binding / Synthesis of 5-eicosatetraenoic acids / glutathione peroxidase / lipoxygenase pathway / Biosynthesis of aspirin-triggered D-series resolvins / Biosynthesis of E-series 18(R)-resolvins / arachidonate metabolic process / Biosynthesis of D-series resolvins / Biosynthesis of E-series 18(S)-resolvins / glutathione peroxidase activity / long-chain fatty acid biosynthetic process / negative regulation of ferroptosis / protein polymerization / phospholipid metabolic process / response to estradiol / nuclear envelope / chromatin organization / spermatogenesis / response to oxidative stress / protein-containing complex / mitochondrion / extracellular exosome / identical protein binding / nucleus / cytosol類似検索 - 分子機能 Glutathione peroxidase active site / Glutathione peroxidases active site. / Glutathione peroxidase / Glutathione peroxidase conserved site / Glutathione peroxidase / Glutathione peroxidases signature 2. / Glutathione peroxidase profile. / Thioredoxin-like superfamily類似検索 - ドメイン・相同性 2-bromo-N-[(thiophen-2-yl)methyl]acetamide / THIOCYANATE ION / Phospholipid hydroperoxide glutathione peroxidase GPX4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.97 Å |
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データ登録者 | Forouhar, F. / Liu, H. / Lin, A.J. / Wang, Q. / Polychronidou, V. / Soni, R.K. / Xia, X. / Stockwell, B.R. |
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資金援助 | 米国, 7件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | P01CA87497 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R24GM141256 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM124165 | 米国 | Department of Health & Human Services (HHS) | OD021527 | 米国 | Department of Energy (DOE, United States) | DE-AC02-06CH11357 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | R35CA209896 | 米国 | National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) | R61NS109407 | 米国 |
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引用 | ジャーナル: Cell Chem Biol / 年: 2022 タイトル: Small-molecule allosteric inhibitors of GPX4. 著者: Liu, H. / Forouhar, F. / Lin, A.J. / Wang, Q. / Polychronidou, V. / Soni, R.K. / Xia, X. / Stockwell, B.R. |
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履歴 | 登録 | 2022年2月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年12月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年12月14日 | Group: Database references / カテゴリ: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2022年12月28日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2023年10月25日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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