Entry | Database: PDB / ID: 7u1m |
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Title | Crystal structure of NTMT1 in complex with compound YD206 |
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Components | N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
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Keywords | TRANSFERASE/INHIBITOR / Methyltransferase / Enzyme / Inhibitor complex / TRANSFERASE / TRANSFERASE-INHIBITOR complex |
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Function / homology | Function and homology information
N-terminal peptidyl-glycine methylation / N-terminal peptidyl-serine dimethylation / N-terminal peptidyl-serine trimethylation / protein N-terminal methyltransferase / N-terminal peptidyl-proline dimethylation / N-terminal protein N-methyltransferase activity / protein methyltransferase activity / spindle organization / histone methyltransferase activity / chromosome segregation ...N-terminal peptidyl-glycine methylation / N-terminal peptidyl-serine dimethylation / N-terminal peptidyl-serine trimethylation / protein N-terminal methyltransferase / N-terminal peptidyl-proline dimethylation / N-terminal protein N-methyltransferase activity / protein methyltransferase activity / spindle organization / histone methyltransferase activity / chromosome segregation / nucleoplasm / nucleus / cytoplasm / cytosolSimilarity search - Function Alpha-N-methyltransferase NTM1 / AdoMet dependent proline di-methyltransferase / S-adenosyl-L-methionine-dependent methyltransferase superfamilySimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 3.17 Å |
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Authors | Yadav, R. / Noinaj, N. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | U01CA214649 | United States |
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Citation | Journal: J.Med.Chem. / Year: 2022 Title: Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner. Authors: Dong, G. / Deng, Y. / Yasgar, A. / Yadav, R. / Talley, D. / Zakharov, A.V. / Jain, S. / Rai, G. / Noinaj, N. / Simeonov, A. / Huang, R. |
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History | Deposition | Feb 21, 2022 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Dec 14, 2022 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 25, 2023 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id ..._struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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