登録情報 | データベース: PDB / ID: 7tvb |
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タイトル | Stat5A Core in Complex with AK305 |
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要素 | Signal transducer and activator of transcription 5A |
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キーワード | TRANSCRIPTION / Stat5a / Activator |
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機能・相同性 | 機能・相同性情報
eosinophil differentiation / taurine metabolic process / reelin-mediated signaling pathway / Interleukin-9 signaling / Interleukin-21 signaling / interleukin-9-mediated signaling pathway / interleukin-4-mediated signaling pathway / interleukin-2-mediated signaling pathway / STAT5 Activation / Erythropoietin activates STAT5 ...eosinophil differentiation / taurine metabolic process / reelin-mediated signaling pathway / Interleukin-9 signaling / Interleukin-21 signaling / interleukin-9-mediated signaling pathway / interleukin-4-mediated signaling pathway / interleukin-2-mediated signaling pathway / STAT5 Activation / Erythropoietin activates STAT5 / interleukin-5-mediated signaling pathway / interleukin-15-mediated signaling pathway / Signaling by cytosolic FGFR1 fusion mutants / Interleukin-15 signaling / interleukin-3-mediated signaling pathway / Signaling by Leptin / Interleukin-2 signaling / Interleukin-20 family signaling / STAT5 activation downstream of FLT3 ITD mutants / Prolactin receptor signaling / cell surface receptor signaling pathway via JAK-STAT / regulation of multicellular organism growth / Interleukin-3, Interleukin-5 and GM-CSF signaling / positive regulation of blood vessel endothelial cell migration / growth hormone receptor signaling pathway via JAK-STAT / Nuclear events stimulated by ALK signaling in cancer / Growth hormone receptor signaling / Nuclear signaling by ERBB4 / Signaling by CSF3 (G-CSF) / positive regulation of endothelial cell proliferation / Signaling by FLT3 fusion proteins / lactation / Interleukin-7 signaling / Downstream signal transduction / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / Inactivation of CSF3 (G-CSF) signaling / Signaling by SCF-KIT / response to peptide hormone / defense response / cytokine-mediated signaling pathway / RNA polymerase II transcription regulator complex / regulation of cell population proliferation / DNA-binding transcription factor binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / chromatin / regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytosol類似検索 - 分子機能 : / STAT5a/5b / : / Signal transducer and activator of transcription, linker domain / STAT transcription factor, DNA-binding, N-terminal / STAT transcription factor, protein interaction / STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding / STAT protein, all-alpha domain / STAT protein, DNA binding domain ...: / STAT5a/5b / : / Signal transducer and activator of transcription, linker domain / STAT transcription factor, DNA-binding, N-terminal / STAT transcription factor, protein interaction / STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding / STAT protein, all-alpha domain / STAT protein, DNA binding domain / STAT protein, protein interaction domain / STAT protein, protein interaction domain / STAT transcription factor, N-terminal domain superfamily / Transcription factor STAT / STAT transcription factor, coiled coil / p53-like transcription factor, DNA-binding / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / SH2 domain superfamily類似検索 - ドメイン・相同性 Chem-KOC / Signal transducer and activator of transcription 5A類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.653 Å |
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データ登録者 | Meagher, J.L. / Stuckey, J.A. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | 1-R01-CA244509 | 米国 |
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引用 | ジャーナル: Nat.Chem.Biol. / 年: 2023 タイトル: A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo. 著者: Kaneshige, A. / Bai, L. / Wang, M. / McEachern, D. / Meagher, J.L. / Xu, R. / Wang, Y. / Jiang, W. / Metwally, H. / Kirchhoff, P.D. / Zhao, L. / Jiang, H. / Wang, M. / Wen, B. / Sun, D. / Stuckey, J.A. / Wang, S. |
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履歴 | 登録 | 2022年2月4日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年2月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年6月7日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.2 | 2024年4月3日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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