登録情報 | データベース: PDB / ID: 7tgp |
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タイトル | E176T/Y188G variant of the internal UBA Domain of HHR23A |
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要素 | UV excision repair protein RAD23 homolog A |
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キーワード | DNA BINDING PROTEIN / ubiquitin associated domain / UBA domain / helical bundle |
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機能・相同性 | 機能・相同性情報
regulation of proteasomal ubiquitin-dependent protein catabolic process / proteasome binding / ubiquitin-specific protease binding / polyubiquitin modification-dependent protein binding / positive regulation of viral genome replication / positive regulation of cell cycle / proteasome complex / Josephin domain DUBs / ubiquitin binding / nucleotide-excision repair ...regulation of proteasomal ubiquitin-dependent protein catabolic process / proteasome binding / ubiquitin-specific protease binding / polyubiquitin modification-dependent protein binding / positive regulation of viral genome replication / positive regulation of cell cycle / proteasome complex / Josephin domain DUBs / ubiquitin binding / nucleotide-excision repair / kinase binding / DNA Damage Recognition in GG-NER / protein destabilization / Formation of Incision Complex in GG-NER / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / single-stranded DNA binding / proteasome-mediated ubiquitin-dependent protein catabolic process / damaged DNA binding / intracellular membrane-bounded organelle / Golgi apparatus / protein-containing complex / nucleoplasm / nucleus / cytoplasm / cytosol類似検索 - 分子機能 RAD23A/RAD23B, UBA1 domain / UV excision repair protein Rad23 / XPC-binding domain / XPC-binding domain superfamily / XPC-binding domain / Heat shock chaperonin-binding / Heat shock chaperonin-binding motif. / UBA/TS-N domain / Ubiquitin associated domain / Ubiquitin-associated domain ...RAD23A/RAD23B, UBA1 domain / UV excision repair protein Rad23 / XPC-binding domain / XPC-binding domain superfamily / XPC-binding domain / Heat shock chaperonin-binding / Heat shock chaperonin-binding motif. / UBA/TS-N domain / Ubiquitin associated domain / Ubiquitin-associated domain / Ubiquitin-associated domain (UBA) profile. / UBA-like superfamily / Ubiquitin family / Ubiquitin homologues / Ubiquitin domain profile. / Ubiquitin-like domain / Ubiquitin-like domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.4 Å |
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データ登録者 | Rothfuss, M. / Bowler, B.E. / McClelland, L.J. / Sprang, S.R. |
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資金援助 | 米国, 3件 組織 | 認可番号 | 国 |
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National Science Foundation (NSF, United States) | CHE-1904895 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | P20GM103546 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | P30GM140963 | 米国 |
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引用 | ジャーナル: J.Am.Chem.Soc. / 年: 2023 タイトル: High-Accuracy Prediction of Stabilizing Surface Mutations to the Three-Helix Bundle, UBA(1), with EmCAST. 著者: Rothfuss, M.T. / Becht, D.C. / Zeng, B. / McClelland, L.J. / Yates-Hansen, C. / Bowler, B.E. |
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履歴 | 登録 | 2022年1月8日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年4月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月25日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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改定 1.2 | 2023年11月1日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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