登録情報 | データベース: PDB / ID: 7te3 |
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タイトル | Crystal Structure of a Double Loop Deletion Mutant in gC1qR/C1qBP/HABP-1 |
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要素 | Complement component 1 Q subcomponent-binding protein, mitochondrial |
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キーワード | IMMUNE SYSTEM / complement / C1q-binding protein / coagulation |
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機能・相同性 | 機能・相同性情報
adrenergic receptor binding / Apoptotic factor-mediated response / Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function / negative regulation of MDA-5 signaling pathway / kininogen binding / negative regulation of RIG-I signaling pathway / negative regulation of defense response to virus / positive regulation of dendritic cell chemotaxis / hyaluronic acid binding / complement component C1q complex binding ...adrenergic receptor binding / Apoptotic factor-mediated response / Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function / negative regulation of MDA-5 signaling pathway / kininogen binding / negative regulation of RIG-I signaling pathway / negative regulation of defense response to virus / positive regulation of dendritic cell chemotaxis / hyaluronic acid binding / complement component C1q complex binding / positive regulation of trophoblast cell migration / mitochondrial ribosome binding / regulation of complement activation / negative regulation of interleukin-12 production / positive regulation of mitochondrial translation / positive regulation of neutrophil chemotaxis / enzyme inhibitor activity / RHOC GTPase cycle / negative regulation of mRNA splicing, via spliceosome / transcription factor binding / negative regulation of type II interferon production / positive regulation of cell adhesion / RHOA GTPase cycle / negative regulation of double-strand break repair via homologous recombination / positive regulation of substrate adhesion-dependent cell spreading / Intrinsic Pathway of Fibrin Clot Formation / RNA splicing / phosphatidylinositol 3-kinase/protein kinase B signal transduction / cytosolic ribosome assembly / complement activation, classical pathway / mRNA processing / transcription corepressor activity / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / mitochondrial matrix / immune response / positive regulation of apoptotic process / innate immune response / mRNA binding / apoptotic process / nucleolus / negative regulation of transcription by RNA polymerase II / cell surface / mitochondrion / extracellular region / membrane / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Mitochondrial glycoprotein / Mitochondrial glycoprotein superfamily / Mitochondrial glycoprotein類似検索 - ドメイン・相同性 Complement component 1 Q subcomponent-binding protein, mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.2 Å |
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データ登録者 | Geisbrecht, B.V. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R35GM140852 | 米国 |
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引用 | ジャーナル: Front Immunol / 年: 2022 タイトル: gC1qR/C1qBP/HABP-1: Structural Analysis of the Trimeric Core Region, Interactions With a Novel Panel of Monoclonal Antibodies, and Their Influence on Binding to FXII. 著者: Zhang, Y. / Vontz, A.J. / Kallenberger, E.M. / Xu, X. / Ploscariu, N.T. / Ramyar, K.X. / Garcia, B.L. / Ghebrehiwet, B. / Geisbrecht, B.V. |
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履歴 | 登録 | 2022年1月4日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年6月1日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年12月14日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2023年10月25日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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