PDB-7t9z: Human Ornithine Aminotransferase (hOAT) crystallized at pH 6.0

ID or keywords:

Entry

Database: PDB / ID: 7t9z

Title

Human Ornithine Aminotransferase (hOAT) crystallized at pH 6.0

Components

Ornithine aminotransferase, mitochondrial

Keywords

TRANSFERASE / Human Ornithine Aminotransferase / hOAT / OAT / PLP

Function / homology

Function and homology information

: / ornithine aminotransferase / L-ornithine transaminase activity / : / L-proline biosynthetic process / Glutamate and glutamine metabolism / visual perception / pyridoxal phosphate binding / mitochondrial matrix / mitochondrion ...
Similarity search - Function

Biological species

Homo sapiens (human)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 2.15 Å

Authors

Butrin, A. / Liu, D.

Funding support

United States, 1items

Citation

Journal: J.Biol.Chem. / Year: 2022
Title: Determination of the pH dependence, substrate specificity, and turnovers of alternative substrates for human ornithine aminotransferase.
Authors: Butrin, A. / Butrin, A. / Wawrzak, Z. / Moran, G.R. / Liu, D.

History

Deposition	Dec 20, 2021	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	May 4, 2022	Provider: repository / Type: Initial release
Revision 1.1	Jun 8, 2022	Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.title / _citation_author.name
Revision 1.2	Oct 18, 2023	Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model

Structure viewer	Molecule: MolmilJmol/JSmol

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PDBx/mmCIF format	7t9z.cif.gz	564 KB	Display	PDBx/mmCIF format
PDB format	pdb7t9z.ent.gz	375.7 KB	Display	PDB format
PDBx/mmJSON format	7t9z.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/t9/7t9z ftp://data.pdbj.org/pub/pdb/validation_reports/t9/7t9z	HTTPS FTP

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Related structure data

Related structure data	7ta0C 7ta1C 1oatS S: Starting model for refinement C: citing same article (ref.)
Similar structure data	Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI

Deposited unit

A: Ornithine aminotransferase, mitochondrial

B: Ornithine aminotransferase, mitochondrial

C: Ornithine aminotransferase, mitochondrial

hetero molecules

147 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

A: Ornithine aminotransferase, mitochondrial

hetero molecules

defined by author
Evidence: gel filtration
48.8 kDa, 1 polymers
Search similar-shape structures of this assembly by Omokage search (details)

2

B: Ornithine aminotransferase, mitochondrial

hetero molecules

defined by author
48.8 kDa, 1 polymers
Search similar-shape structures of this assembly by Omokage search (details)

3

C: Ornithine aminotransferase, mitochondrial

hetero molecules

defined by author
48.8 kDa, 1 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	200.910, 110.860, 56.930
Angle α, β, γ (deg.)	90.000, 106.404, 90.000
Int Tables number	5
Space group name H-M	C121
Space group name Hall	C2y
Symmetry operation	#1: x,y,z #2: -x,y,-z #3: x+1/2,y+1/2,z #4: -x+1/2,y+1/2,-z

Components on special symmetry positions

ID	Model	Components
1	1	A-654- HOH
2	1	A-665- HOH
3	1	B-647- HOH

Noncrystallographic symmetry (NCS)

NCS domain:

ID	Ens-ID	Details
d_1	ens_1	(chain "A" and (resid 38 through 44 or resid 47...
d_2	ens_1	(chain "B" and (resid 38 through 44 or resid 47...
d_3	ens_1	(chain "C" and (resid 38 through 44 or resid 47...

NCS domain segments:

Dom-ID	Component-ID	Ens-ID	Beg label comp-ID	End label comp-ID	Label asym-ID	Label seq-ID
d_1	1	ens_1	PRO	PHE	A	1 - 7
d_1	2	ens_1	GLU	TYR	A	10 - 11
d_1	3	ens_1	TYR	GLU	A	13 - 26
d_1	4	ens_1	GLY	ASP	A	28 - 69
d_1	5	ens_1	LEU	PHE	A	71 - 94
d_1	6	ens_1	TYR	GLY	A	96 - 142
d_1	7	ens_1	THR	ALA	A	144 - 309
d_1	8	ens_1	ASN	ASP	A	311 - 313
d_1	9	ens_1	LEU	THR	A	315 - 348
d_1	10	ens_1	ASP	TRP	A	350 - 354
d_1	11	ens_1	VAL	ALA	A	356 - 367
d_1	12	ens_1	PRO	THR	A	369 - 370
d_1	13	ens_1	GLY	ILE	A	372 - 383
d_1	14	ens_1	GLU	ASN	A	385 - 396
d_1	15	ens_1	THR	PHE	A	398 - 402
d_1	16	ens_1	PLP	PLP	B
d_2	1	ens_1	PRO	PHE	C	1 - 7
d_2	2	ens_1	GLU	TYR	C	10 - 11
d_2	3	ens_1	TYR	GLU	C	13 - 26
d_2	4	ens_1	GLY	ASP	C	28 - 69
d_2	5	ens_1	LEU	PHE	C	71 - 94
d_2	6	ens_1	TYR	GLY	C	96 - 142
d_2	7	ens_1	THR	ALA	C	144 - 309
d_2	8	ens_1	ASN	ASP	C	311 - 313
d_2	9	ens_1	LEU	THR	C	315 - 348
d_2	10	ens_1	ASP	TRP	C	350 - 354
d_2	11	ens_1	VAL	ALA	C	356 - 367
d_2	12	ens_1	PRO	THR	C	369 - 370
d_2	13	ens_1	GLY	ILE	C	372 - 383
d_2	14	ens_1	GLU	ASN	C	385 - 396
d_2	15	ens_1	THR	PHE	C	398 - 402
d_2	16	ens_1	PLP	PLP	D
d_3	1	ens_1	PRO	PHE	E	1 - 7
d_3	2	ens_1	GLU	TYR	E	10 - 11
d_3	3	ens_1	TYR	GLU	E	13 - 26
d_3	4	ens_1	GLY	ASP	E	28 - 69
d_3	5	ens_1	LEU	PHE	E	71 - 94
d_3	6	ens_1	TYR	GLY	E	96 - 142
d_3	7	ens_1	THR	ALA	E	144 - 309
d_3	8	ens_1	ASN	ASP	E	311 - 313
d_3	9	ens_1	LEU	THR	E	315 - 348
d_3	10	ens_1	ASP	TRP	E	350 - 354
d_3	11	ens_1	VAL	ALA	E	356 - 367
d_3	12	ens_1	PRO	THR	E	369 - 370
d_3	13	ens_1	GLY	ILE	E	372 - 383
d_3	14	ens_1	GLU	ASN	E	385 - 396
d_3	15	ens_1	THR	PHE	E	398 - 402
d_3	16	ens_1	PLP	PLP	F

NCS oper:

ID	Code	Matrix	Vector
1	given	(0.37818394109, -0.83126294656, 0.407404983252), (-0.832004581342, -0.498167950402, -0.244125110995), (0.405888264585, -0.246638615932, -0.880013698645)	23.6185193341, 52.3174750167, 26.7571636424
2	given	(-0.378343412943, -0.830358012627, -0.409098805606), (0.832687590933, -0.498346046234, 0.241417882746), (-0.404336045622, -0.24931263319, 0.879974757105)	23.6290794851, 52.3103571762, 26.8370567152

#1: Protein	Ornithine aminotransferase, mitochondrial / Ornithine delta-aminotransferase / Ornithine--oxo-acid aminotransferase Mass: 48593.668 Da / Num. of mol.: 3 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: OAT / Production host: Escherichia coli (E. coli) / References: UniProt: P04181, ornithine aminotransferase
#2: Chemical	ChemComp-PLP / PYRIDOXAL-5'-PHOSPHATE / VITAMIN B6 Phosphate Mass: 247.142 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: C₈H₁₀NO₆P / Feature type: SUBJECT OF INVESTIGATION
#3: Water	ChemComp-HOH / water Mass: 18.015 Da / Num. of mol.: 576 / Source method: isolated from a natural source / Formula: H₂O
Has ligand of interest	Y

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.09 Å³/Da / Density % sol: 41.03 %
Crystal grow	Temperature: 293 K / Method: vapor diffusion, hanging drop / pH: 6 Details: Purified holo-hOAT was buffer-exchanged into 100 mM MES, 200 mM NaCl, 100 uM PLP, pH 6.0 buffer, and then concentrated to ~6 mg/mL. The crystallization was performed via the hanging drop ...Details: Purified holo-hOAT was buffer-exchanged into 100 mM MES, 200 mM NaCl, 100 uM PLP, pH 6.0 buffer, and then concentrated to ~6 mg/mL. The crystallization was performed via the hanging drop vapor diffusion method according to previously published conditions with 50 mM Tricine pH 7.8 substituted to 50 mM MES pH 6.0 buffer. The crystals grew at room temperature within three days and reached their maximum size in a week.

Crystal

Density Matthews: 2.09 Å³/Da / Density % sol: 41.03 %

Crystal grow

Temperature: 293 K / Method: vapor diffusion, hanging drop / pH: 6
Details: Purified holo-hOAT was buffer-exchanged into 100 mM MES, 200 mM NaCl, 100 uM PLP, pH 6.0 buffer, and then concentrated to ~6 mg/mL. The crystallization was performed via the hanging drop ...

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Data collection

Diffraction	Mean temperature: 100 K / Serial crystal experiment: N
Diffraction source	Source: SYNCHROTRON / Site: APS / Beamline: 21-ID-D / Wavelength: 1.127 Å
Detector	Type: DECTRIS EIGER X 9M / Detector: PIXEL / Date: Apr 17, 2021
Radiation	Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 1.127 Å / Relative weight: 1
Reflection	Resolution: 1.99→96.1 Å / Num. obs: 60876 / % possible obs: 92.5 % / Redundancy: 3.4 % / CC_1/2: 0.986 / R_pim(I) all: 0.133 / Net I/σ(I): 4.9
Reflection shell	Resolution: 1.99→2.02 Å / Mean I/σ(I) obs: 1.2 / Num. unique obs: 14325 / CC_1/2: 0.371

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Processing

Software

Name	Version	Classification
PHENIX	1.19.2_4158	refinement
MOSFLM		data reduction
Aimless		data scaling
PHASER		phasing

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT
Starting model: 1OAT

1oat

Resolution: 2.15→54.61 Å / Cross valid method: FREE R-VALUE / σ(F): 56.84 / Phase error: 31.097
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2

	R_factor	Num. reflection	% reflection
R_free	0.2759	3272	2.9 %
R_work	0.2656	109445	-
obs	0.2706	112717	87.92 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL

Displacement parameters

B_iso mean: 23.88 Å²

Refinement step

Cycle: LAST / Resolution: 2.15→54.61 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	9450	0	45	576	10071

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.0063	9723
X-RAY DIFFRACTION	f_angle_d	0.6649	13210
X-RAY DIFFRACTION	f_chiral_restr	0.0471	1462
X-RAY DIFFRACTION	f_plane_restr	0.0051	1697
X-RAY DIFFRACTION	f_dihedral_angle_d	5.5229	1329

Refine LS restraints NCS

Ens-ID	Dom-ID	Auth asym-ID	Refine-ID	Type	Rms dev position (Å)
ens_1	d_2	A	X-RAY DIFFRACTION	Torsion NCS	0.535629373591
ens_1	d_3	A	X-RAY DIFFRACTION	Torsion NCS	0.558752351079

LS refinement shell

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	Refine-ID	% reflection obs (%)
2.15-2.19	0.316	144	0.3053	5417	X-RAY DIFFRACTION	83.8
2.19-2.23	0.2594	146	0.2985	5425	X-RAY DIFFRACTION	85.12
2.23-2.27	0.3054	155	0.2975	5462	X-RAY DIFFRACTION	85.08
2.27-2.32	0.2879	152	0.2907	5414	X-RAY DIFFRACTION	85.11
2.32-2.37	0.3391	158	0.3043	5434	X-RAY DIFFRACTION	84.12
2.37-2.42	0.3148	142	0.3109	5499	X-RAY DIFFRACTION	86.53
2.42-2.48	0.3067	154	0.2972	5626	X-RAY DIFFRACTION	86.57
2.48-2.55	0.2797	131	0.2887	5297	X-RAY DIFFRACTION	82.97
2.55-2.62	0.3066	128	0.2947	4265	X-RAY DIFFRACTION	67.24
2.62-2.71	0.2713	135	0.2662	4996	X-RAY DIFFRACTION	77.11
2.71-2.81	0.2931	156	0.2797	5788	X-RAY DIFFRACTION	90.91
2.81-2.92	0.3058	164	0.2725	5911	X-RAY DIFFRACTION	91.84
2.92-3.05	0.2561	156	0.2642	5880	X-RAY DIFFRACTION	91.75
3.05-3.21	0.2618	151	0.2609	5796	X-RAY DIFFRACTION	91.02
3.21-3.41	0.2892	157	0.2552	5787	X-RAY DIFFRACTION	90.03
3.41-3.68	0.2365	157	0.2504	5702	X-RAY DIFFRACTION	88.76
3.68-4.05	0.2437	159	0.2429	5741	X-RAY DIFFRACTION	89.49
4.05-4.63	0.2704	141	0.2382	5360	X-RAY DIFFRACTION	83.7
4.63-5.83	0.2885	127	0.2531	4817	X-RAY DIFFRACTION	75.04
5.83-54.61	0.3354	168	0.2978	6119	X-RAY DIFFRACTION	95.58

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	0.00365380483133	-0.00343063513734	0.00255052883037	0.00395239194078	-0.00436623325335	0.00340276088006	0.0118804140426	0.0132773001432	-0.00824643782557	-0.00324397231522	-0.0072724340043	-0.00762275054612	0.0236687220888	0.00702444019153	-0.00629536565214	0.10401641811	0.0508548206663	-0.0476143085385	0.194671034837	0.0209175556629	0.0431654976695	15.6381437217	-8.95768030422	0.716661166232
2	-0.00100094772483	0.00447297919901	0.0031799291111	-0.00219348345733	0.00117753372709	0.00962858026214	0.00195700994501	-0.0196699021269	-0.00619897213291	0.0109823712618	-0.00279906039211	0.0204244565378	0.0190076992071	-0.00758256499156	-0.00452267531474	0.0521614361124	-0.0318962691007	-0.0463155588088	0.169461645969	-0.0114694131452	-0.110043207651	-2.057400701	12.0421072663	9.81752601672
3	0.000505948721369	0.000393272958104	0.00384129198353	-0.0031015305693	0.00264791344869	0.0066248441729	0.00522582952497	-0.0360177375105	-0.00934295006602	0.0258539016871	-0.0109597976996	-0.0276032526544	0.0127269551415	0.0125037753623	-0.0339240483554	0.0707227431089	0.00472031041482	-0.0897312476319	0.217073396077	0.0170827430212	-0.112267544392	6.95676451459	4.71242148608	17.6113244281
4	0.00125084024211	0.000726515214496	0.00215635537102	0.000676209726275	0.00164905310998	0.00419703039379	0.00759273900664	0.00169548642643	-0.00903556888996	-0.000286681717765	0.00785519607575	-0.00243519044313	0.00974179518504	0.00663331659189	0.00947091388243	0.08746807931	0.0669628418297	-0.0468981009295	0.177329977602	-0.0100870548437	0.048565083504	26.6333335931	-4.20235490262	12.4395244339
5	0.00191975335605	0.00421667698155	0.00491987724716	0.00423423136875	0.00495276746281	0.00577160987217	-0.00971579586829	-0.0107351663245	0.00428489579198	0.0164937101611	0.0236342432944	-0.0113636539429	0.00451407701179	0.0103664060424	0.0151476209155	0.0687126215928	0.0381696683805	-0.0334127712007	0.164256066298	-0.0238183303072	0.0276125486414	37.3206065423	43.5906298379	34.6553891298
6	-0.00316465902012	0.000214169735009	0.00141320861755	-0.000423495024511	0.000502023999119	0.00680281350765	0.00272371924877	0.0158262667252	0.0129528037345	-0.0211417288852	0.00110775946324	0.00430790772799	-0.008758135735	0.0103420609925	0.00493321791548	0.0526028951899	-0.0128789906011	-0.010515989782	0.159965588545	-0.0166500924368	-0.10459815225	16.8408318929	45.6016845397	14.3130921183
7	0.00158560781765	-0.000838121860754	-0.000939509199287	1.74486858957E-5	0.00116349818816	0.00282405132476	-0.00447617993499	-0.00292650103518	-0.00246390261298	-0.00352648506412	-0.00896552843724	0.0019303355478	-0.00261613896296	-0.00753488989177	-0.0201215702821	0.0818439144293	0.0233311977865	-0.028387697603	0.169589856057	-0.00739585071484	-0.0171054838918	20.4017380365	35.669302079	5.85805457889
8	0.000725852949588	-0.00246301979756	-0.00249777532059	0.0025055904859	0.00102018508566	0.00484019683242	0.00889490981551	0.000541701854613	-0.00296264575613	-0.00824480108231	0.00895727358	-0.0132802606295	-0.00243591779475	0.0190699247346	0.0243344469756	0.0411238620814	-0.00142290789514	0.00395865065773	0.169488613913	-0.0321588856048	-0.0479561826035	31.5730473572	46.8991328162	13.2859439446
9	0.00264915768042	0.00200401688476	0.00106851173751	0.00216111426509	-7.65474367602E-5	0.00160378193481	0.00864947651429	0.00140386783518	-0.0116446671367	0.00405580783922	0.00313900703091	-0.00231116185475	0.0065092466703	0.000333068009178	-0.000499764873038	0.134573355464	0.0304147361558	-0.0186418311298	0.172770920329	-0.0338480835448	0.0932040623876	36.4165313648	21.1365296438	22.9312202361
10	4.9113302371E-5	-2.59230928862E-5	-0.00123115478029	0.000556009738207	0.00276415259283	0.00964827608785	0.000586108748468	-0.00457518528149	0.000822557816985	0.00610833812052	0.00107563677993	-0.00313329867686	0.012050934015	0.00195398189224	0.00144273762371	0.102351059059	0.0480145926949	-0.037929461604	0.213463444248	-0.0394449397886	0.0494692178133	42.2111939874	29.2501637681	27.5914341431
11	-0.000107890550107	0.000200397069082	-4.2357568205E-5	-4.42141407452E-5	-6.52973356347E-5	4.16665135296E-5	0.00464100492451	-0.000648296630986	0.00360063713376	-0.00250792148362	0.00172759492083	-0.00177568168615	-0.00167493388823	-0.00374981175154	0.00280938074355	0.118538738295	-0.00315796264283	0.0213114662085	0.130513805963	0.0189820351957	0.0425656064505	21.5541086199	68.6705206933	11.0088185567
12	0.00209674331214	-0.000905057564967	-0.000575918084701	0.00588610871577	-0.0108559944095	0.0210616929022	0.0173661607518	-0.00568504110371	0.0133470552808	-0.00361760321022	0.0209693388385	-0.00234348278818	-0.00305422007036	0.0218999012555	0.0293194305992	0.117143675826	-0.0405950059458	0.00493721638752	0.177417618822	-0.0196526824704	0.0810254836012	26.6882577227	70.7451953413	30.3486793973
13	0.00620772590356	-0.000595877309888	-0.00400948484537	-0.000416622611452	-0.00347023798242	0.00894884801578	-0.000261578937592	-0.0156369463582	-0.00844514733333	0.0159991778552	0.015835993871	-0.00093754215073	0.00605326807544	-0.0108152381939	0.0298238978812	0.061861141021	0.0103002111973	-0.0207931166707	0.212175855949	-0.0226264099603	-0.0554249601983	16.0883777335	45.3301790241	36.1275733549
14	0.00149295050858	-0.00216101579959	0.00264075176337	0.00184769325549	-0.00118099447307	0.00415350798288	0.00666370069026	-0.00581852310967	-0.00320122610996	0.00487480027091	0.00342244652153	0.00689906825595	0.000192243823688	-0.0076634768623	0.0232976131856	0.039241348582	0.0120534826706	-0.00265483638197	0.137315780325	-0.00433247634128	-7.40961253828E-5	-1.63800777533	50.7293040716	27.0733753798
15	0.00177851146393	0.00205229651196	-0.00683750600108	0.00329781784522	-0.0044371828726	0.0169126760754	-0.0111124382701	-0.00444025910784	-0.000981566723981	0.00683172869182	0.0047629091513	0.00234052722592	0.00623553100226	-0.00547870694729	-0.0127869744993	0.0738052939553	0.0236243520773	0.0306533258092	0.128625547214	-0.00205755520127	0.00386440734442	0.0200196557724	52.8670982584	39.7406281468
16	6.15490670105E-5	-0.000253830218352	0.0029697587588	0.00172109134771	0.000824306854011	0.00649824196549	0.00631686305808	-0.00786694641459	-0.0012401369975	0.000891033980259	-0.00150323209697	0.00082409566891	0.00710741308806	0.00580152328964	0.0035861207228	0.0551030223324	-0.00585013270938	-0.0101101294178	0.166840060757	-0.0194818283343	-0.0269039431776	15.6333100463	52.1410835475	39.4811748167
17	0.00915829320777	0.0083260010127	-0.0077846691134	0.0204370137412	-0.0161070937926	0.0142484486999	0.0162182945889	0.00143736350955	0.0235793675079	0.00914610944801	0.0264240919166	-0.00322782540489	-0.000885341943227	-0.00463930344449	0.0668121038889	0.0948662464822	0.00461327252271	-0.00981361997628	0.156167598844	-0.0518614217518	0.0401558338499	10.9592967741	72.5919851792	36.2634178682
18	0.00201569818592	0.00293884064618	0.00157945834494	0.0048348682943	0.00206998225181	0.00105891308453	0.00885986694646	0.0130824483946	0.0151276652033	-0.000373422209713	0.00959294923816	0.00442368038562	-0.00573318245428	-0.00196637605511	0.000277373248903	0.125556788156	-0.00891894997668	0.0348156330305	0.183558523606	-0.0184742996611	0.105067335771	11.9960941059	79.5027264872	28.1857697329

Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

ID	Refine TLS-ID	Selection details	Auth asym-ID	Label asym-ID	Auth seq-ID	Label seq-ID
1	1	chain 'A' and (resid 38 through 105 )	A	A	38 - 105	1 - 68
2	2	chain 'A' and (resid 106 through 220 )	A	A	106 - 220	69 - 183
3	3	chain 'A' and (resid 221 through 389 )	A	A	221 - 389	184 - 352
4	4	chain 'A' and (resid 390 through 439 )	A	A	390 - 439	353 - 402
5	5	chain 'B' and (resid 38 through 105 )	B	C	38 - 105	1 - 68
6	6	chain 'B' and (resid 106 through 220 )	B	C	106 - 220	69 - 183
7	7	chain 'B' and (resid 221 through 263 )	B	C	221 - 263	184 - 226
8	8	chain 'B' and (resid 264 through 362 )	B	C	264 - 362	227 - 325
9	9	chain 'B' and (resid 363 through 389 )	B	C	363 - 389	326 - 352
10	10	chain 'B' and (resid 390 through 439 )	B	C	390 - 439	353 - 402
11	11	chain 'C' and (resid 38 through 61 )	C	E	38 - 61	1 - 24
12	12	chain 'C' and (resid 62 through 105 )	C	E	62 - 105	25 - 68
13	13	chain 'C' and (resid 106 through 181 )	C	E	106 - 181	69 - 144
14	14	chain 'C' and (resid 182 through 220 )	C	E	182 - 220	145 - 183
15	15	chain 'C' and (resid 221 through 263 )	C	E	221 - 263	184 - 226
16	16	chain 'C' and (resid 264 through 326 )	C	E	264 - 326	227 - 289
17	17	chain 'C' and (resid 327 through 389 )	C	E	327 - 389	290 - 352
18	18	chain 'C' and (resid 390 through 439 )	C	E	390 - 439	353 - 402

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