登録情報 データベース : PDB / ID : 7t8j 構造の表示 ダウンロードとリンクタイトル The ubiquitin-associated domain of human thirty-eight negative kinase-1 flexibly fused to the 1TEL crystallization chaperone via a GSGG linker 要素Transcription factor ETV6,Non-receptor tyrosine-protein kinase TNK1 詳細 キーワード ONCOPROTEIN / Protein polymer / Ubiquitin-associated domain / Helix bundle / Chimera機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB / mesenchymal cell apoptotic process / vitellogenesis / hematopoietic stem cell proliferation / Signaling by FLT3 fusion proteins / neurogenesis / RNA polymerase II transcription regulatory region sequence-specific DNA binding / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / DNA-binding transcription repressor activity, RNA polymerase II-specific ... Signaling by membrane-tethered fusions of PDGFRA or PDGFRB / mesenchymal cell apoptotic process / vitellogenesis / hematopoietic stem cell proliferation / Signaling by FLT3 fusion proteins / neurogenesis / RNA polymerase II transcription regulatory region sequence-specific DNA binding / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / DNA-binding transcription repressor activity, RNA polymerase II-specific / protein tyrosine kinase activity / DNA-binding transcription activator activity, RNA polymerase II-specific / protein autophosphorylation / DNA-binding transcription factor activity, RNA polymerase II-specific / protein phosphorylation / DNA-binding transcription factor activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / protein domain specific binding / chromatin / regulation of transcription by RNA polymerase II / nucleolus / negative regulation of transcription by RNA polymerase II / ATP binding / membrane / nucleus / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 : / SAM domain-like / SAM / Pointed domain / Pointed domain / Sterile alpha motif (SAM)/Pointed domain / Pointed (PNT) domain profile. / Ets-domain signature 2. / Ets domain / ETS family / Ets-domain ... : / SAM domain-like / SAM / Pointed domain / Pointed domain / Sterile alpha motif (SAM)/Pointed domain / Pointed (PNT) domain profile. / Ets-domain signature 2. / Ets domain / ETS family / Ets-domain / Ets-domain profile. / erythroblast transformation specific domain / : / Sterile alpha motif/pointed domain superfamily / Src homology 3 domains / Src homology 3 (SH3) domain profile. / SH3 domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性 Transcription factor ETV6 / Non-receptor tyrosine-protein kinase TNK1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.89 Å 詳細データ登録者 Soleimani, S. / Pedroza Romo, M.J. / Smith, T. / Brown, S. / Doukov, T. / Moody, J.D. 資金援助 米国, 1件 詳細 詳細を隠す組織 認可番号 国 Other private 米国
引用ジャーナル : Structure / 年 : 2023タイトル : Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain.著者: Nawarathnage, S. / Tseng, Y.J. / Soleimani, S. / Smith, T. / Pedroza Romo, M.J. / Abiodun, W.O. / Egbert, C.M. / Madhusanka, D. / Bunn, D. / Woods, B. / Tsubaki, E. / Stewart, C. / Brown, S. ... 著者 : Nawarathnage, S. / Tseng, Y.J. / Soleimani, S. / Smith, T. / Pedroza Romo, M.J. / Abiodun, W.O. / Egbert, C.M. / Madhusanka, D. / Bunn, D. / Woods, B. / Tsubaki, E. / Stewart, C. / Brown, S. / Doukov, T. / Andersen, J.L. / Moody, J.D. 履歴 登録 2021年12月16日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2022年12月21日 Provider : repository / タイプ : Initial release改定 1.1 2023年1月11日 Group : Refinement description / カテゴリ : refine / software / Item : _refine.pdbx_starting_model / _software.version改定 2.0 2023年3月22日 Group : Advisory / Atomic model ... Advisory / Atomic model / Database references / Polymer sequence / Structure summary カテゴリ : atom_site / atom_site_anisotrop ... atom_site / atom_site_anisotrop / citation / entity / entity_poly / entity_poly_seq / pdbx_poly_seq_scheme / pdbx_unobs_or_zero_occ_atoms / struct / struct_ref_seq_dif Item : _atom_site.auth_comp_id / _atom_site.label_comp_id ... _atom_site.auth_comp_id / _atom_site.label_comp_id / _atom_site_anisotrop.pdbx_auth_comp_id / _atom_site_anisotrop.pdbx_label_comp_id / _citation.title / _entity.formula_weight / _entity.pdbx_mutation / _entity_poly.pdbx_seq_one_letter_code / _entity_poly.pdbx_seq_one_letter_code_can / _entity_poly_seq.mon_id / _pdbx_poly_seq_scheme.mon_id / _pdbx_poly_seq_scheme.pdb_mon_id / _struct.title / _struct_ref_seq_dif.mon_id 改定 2.1 2023年10月25日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model改定 2.2 2023年11月15日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 2.3 2023年12月20日 Group : Database references / カテゴリ : citation / Item : _citation.journal_volume / _citation.page_first
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