登録情報 | データベース: PDB / ID: 7t2l |
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タイトル | Crystal Structure of TEAD2 in a covalent complex with TED-662 |
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要素 | Transcriptional enhancer factor TEF-4 |
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キーワード | TRANSCRIPTION / TEAD / inhibitor / complex / covalent / allosteric / Transcriptional enhancer factor TEF-4 |
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機能・相同性 | 機能・相同性情報
TEAD-YAP complex / lateral mesoderm development / RUNX3 regulates YAP1-mediated transcription / notochord development / YAP1- and WWTR1 (TAZ)-stimulated gene expression / paraxial mesoderm development / hippo signaling / regulation of stem cell differentiation / Formation of axial mesoderm / embryonic heart tube morphogenesis ...TEAD-YAP complex / lateral mesoderm development / RUNX3 regulates YAP1-mediated transcription / notochord development / YAP1- and WWTR1 (TAZ)-stimulated gene expression / paraxial mesoderm development / hippo signaling / regulation of stem cell differentiation / Formation of axial mesoderm / embryonic heart tube morphogenesis / vasculogenesis / embryonic organ development / cellular response to retinoic acid / neural tube closure / transcription coactivator binding / sequence-specific double-stranded DNA binding / disordered domain specific binding / protein-containing complex assembly / transcription regulator complex / transcription by RNA polymerase II / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / intracellular membrane-bounded organelle / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytosol類似検索 - 分子機能 TEA/ATTS domain / Transcriptional enhancer factor, metazoa / TEA/ATTS domain superfamily / TEA/ATTS domain / TEA domain signature. / TEA domain profile. / TEA domain / YAP binding domain / YAP binding domain類似検索 - ドメイン・相同性 Chem-EFI / Transcriptional enhancer factor TEF-4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.15 Å |
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データ登録者 | Bum-Erdene, K. / Gonzalez-Gutierrez, G. / Meroueh, S.O. |
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資金援助 | 米国, 4件 組織 | 認可番号 | 国 |
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American Cancer Society | RSG-12-092-01-CDD | 米国 | Other private | Vera Bradley Foundation | 米国 | Other government | Indiana University Simon Cancer Center Near Miss Initiative grant | 米国 | Other private | 100 Voices of Hope | 米国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2023 タイトル: Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists. 著者: Bum-Erdene, K. / Yeh, I.J. / Gonzalez-Gutierrez, G. / Ghozayel, M.K. / Pollok, K. / Meroueh, S.O. |
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履歴 | 登録 | 2021年12月5日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年6月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月25日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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