登録情報 データベース : PDB / ID : 7t1d 構造の表示 ダウンロードとリンクタイトル Human SIRT2 in complex with small molecule 359 要素NAD-dependent protein deacetylase sirtuin-2 詳細 キーワード HYDROLASE/INHIBITOR / Allosteric inhibitor / HYDROLASE / HYDROLASE-INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
cellular response to caloric restriction / negative regulation of oligodendrocyte progenitor proliferation / cellular lipid catabolic process / negative regulation of striated muscle tissue development / NAD-dependent histone H4K16 deacetylase activity / positive regulation of meiotic nuclear division / positive regulation of attachment of spindle microtubules to kinetochore / NAD-dependent protein demyristoylase activity / NAD-dependent protein depalmitoylase activity / paranodal junction ... cellular response to caloric restriction / negative regulation of oligodendrocyte progenitor proliferation / cellular lipid catabolic process / negative regulation of striated muscle tissue development / NAD-dependent histone H4K16 deacetylase activity / positive regulation of meiotic nuclear division / positive regulation of attachment of spindle microtubules to kinetochore / NAD-dependent protein demyristoylase activity / NAD-dependent protein depalmitoylase activity / paranodal junction / tubulin deacetylation / lateral loop / NLRP3 inflammasome complex assembly / peptidyl-lysine deacetylation / mitotic nuclear membrane reassembly / negative regulation of NLRP3 inflammasome complex assembly / tubulin deacetylase activity / regulation of exit from mitosis / paranode region of axon / NAD-dependent protein lysine deacetylase activity / Schmidt-Lanterman incisure / positive regulation of fatty acid biosynthetic process / myelination in peripheral nervous system / rDNA heterochromatin formation / protein acetyllysine N-acetyltransferase / chromatin silencing complex / regulation of phosphorylation / Initiation of Nuclear Envelope (NE) Reformation / protein deacetylation / NAD-dependent histone deacetylase activity / positive regulation of oocyte maturation / juxtaparanode region of axon / protein lysine deacetylase activity / meiotic spindle / response to redox state / regulation of myelination / histone acetyltransferase binding / histone deacetylase activity / negative regulation of fat cell differentiation / negative regulation of peptidyl-threonine phosphorylation / positive regulation of execution phase of apoptosis / glial cell projection / positive regulation of cell division / NAD+-protein poly-ADP-ribosyltransferase activity / NAD+ binding / subtelomeric heterochromatin formation / negative regulation of reactive oxygen species metabolic process / positive regulation of DNA binding / heterochromatin / epigenetic regulation of gene expression / heterochromatin formation / 転移酵素; アシル基を移すもの; アミノアシル基以外のアシル基を移すもの / cellular response to epinephrine stimulus / substantia nigra development / centriole / negative regulation of autophagy / meiotic cell cycle / ubiquitin binding / negative regulation of protein catabolic process / mitotic spindle / autophagy / histone deacetylase binding / spindle / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / myelin sheath / chromosome / cellular response to oxidative stress / midbody / growth cone / cellular response to hypoxia / perikaryon / proteasome-mediated ubiquitin-dependent protein catabolic process / DNA-binding transcription factor binding / microtubule / chromosome, telomeric region / regulation of cell cycle / cell division / innate immune response / negative regulation of DNA-templated transcription / centrosome / chromatin binding / nucleolus / perinuclear region of cytoplasm / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / mitochondrion / zinc ion binding / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 Sirtuin, class I / Sirtuin, catalytic core small domain superfamily / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / DHS-like NAD/FAD-binding domain superfamily 類似検索 - ドメイン・相同性 Chem-E7K / NAD-dependent protein deacetylase sirtuin-2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.75 Å 詳細データ登録者 Kulp, J.L. / Remiszewski, S. / Todd, M. / Chiang, L.W. 資金援助 米国, 1件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) R44AI122488 米国
引用ジャーナル : J.Clin.Invest. / 年 : 2023タイトル : An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity.著者: Roche, K.L. / Remiszewski, S. / Todd, M.J. / Kulp 3rd, J.L. / Tang, L. / Welsh, A.V. / Barry, A.P. / De, C. / Reiley, W.W. / Wahl, A. / Garcia, J.V. / Luftig, M.A. / Shenk, T. / Tonra, J.R. / ... 著者 : Roche, K.L. / Remiszewski, S. / Todd, M.J. / Kulp 3rd, J.L. / Tang, L. / Welsh, A.V. / Barry, A.P. / De, C. / Reiley, W.W. / Wahl, A. / Garcia, J.V. / Luftig, M.A. / Shenk, T. / Tonra, J.R. / Murphy, E.A. / Chiang, L.W. 履歴 登録 2021年12月1日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2023年5月17日 Provider : repository / タイプ : Initial release改定 1.1 2023年6月28日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.2 2023年10月25日 Group : Data collection / Database references ... Data collection / Database references / Source and taxonomy / Structure summary カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / entity / entity_name_com / entity_src_gen / pdbx_entity_src_syn / struct_ref / struct_ref_seq Item : _entity.pdbx_ec / _entity.src_method ... _entity.pdbx_ec / _entity.src_method / _struct_ref.db_code / _struct_ref.pdbx_align_begin / _struct_ref.pdbx_db_accession / _struct_ref_seq.db_align_beg / _struct_ref_seq.db_align_end / _struct_ref_seq.pdbx_db_accession 改定 1.3 2024年4月3日 Group : Refinement description / カテゴリ : pdbx_initial_refinement_model
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