登録情報 | データベース: PDB / ID: 7ruq |
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タイトル | Structure of the human GIGYF1-TNRC6C complex |
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要素 | - GRB10-interacting GYF protein 1
- Trinucleotide repeat-containing gene 6C protein
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キーワード | GENE REGULATION (遺伝子発現の調節) / miRNA / 4EHP / translation repression |
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機能・相同性 | 機能・相同性情報
Regulation of CDH11 mRNA translation by microRNAs / Regulation of NPAS4 mRNA translation / Post-transcriptional silencing by small RNAs / Competing endogenous RNAs (ceRNAs) regulate PTEN translation / Regulation of PTEN mRNA translation / Transcriptional Regulation by MECP2 / miRNA-mediated post-transcriptional gene silencing / miRNA-mediated gene silencing by inhibition of translation / Regulation of RUNX1 Expression and Activity / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ...Regulation of CDH11 mRNA translation by microRNAs / Regulation of NPAS4 mRNA translation / Post-transcriptional silencing by small RNAs / Competing endogenous RNAs (ceRNAs) regulate PTEN translation / Regulation of PTEN mRNA translation / Transcriptional Regulation by MECP2 / miRNA-mediated post-transcriptional gene silencing / miRNA-mediated gene silencing by inhibition of translation / Regulation of RUNX1 Expression and Activity / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / positive regulation of nuclear-transcribed mRNA poly(A) tail shortening / Regulation of MECP2 expression and activity / Transcriptional Regulation by VENTX / Nuclear events stimulated by ALK signaling in cancer / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / insulin-like growth factor receptor signaling pathway / TP53 Regulates Metabolic Genes / MAPK6/MAPK4 signaling / P-body / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / Oncogene Induced Senescence / Pre-NOTCH Transcription and Translation / Ca2+ pathway / Oxidative Stress Induced Senescence / Estrogen-dependent gene expression / protein-containing complex / RNA binding / 核質 / 細胞質基質類似検索 - 分子機能 TNRC6C, RNA recognition motif / Trinucleotide repeat-containing gene 6C protein, UBA domain / GW182, middle domain / M domain of GW182 / TNRC6, PABC binding domain / TNRC6-PABC binding domain / Argonaute hook domain / Argonaute hook / GYF domain / GYF-like domain superfamily ...TNRC6C, RNA recognition motif / Trinucleotide repeat-containing gene 6C protein, UBA domain / GW182, middle domain / M domain of GW182 / TNRC6, PABC binding domain / TNRC6-PABC binding domain / Argonaute hook domain / Argonaute hook / GYF domain / GYF-like domain superfamily / GYF domain / GYF domain profile. / Contains conserved Gly-Tyr-Phe residues / UBA/TS-N domain / Ubiquitin associated domain / Ubiquitin-associated domain / Ubiquitin-associated domain (UBA) profile. / UBA-like superfamily / RNA認識モチーフ / RNA recognition motif domain / RNA-binding domain superfamily / Nucleotide-binding alpha-beta plait domain superfamily類似検索 - ドメイン・相同性 GRB10-interacting GYF protein 1 / Trinucleotide repeat-containing gene 6C protein類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.79 Å |
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データ登録者 | Sobti, M. / Mead, B.J. / Igreja, C. / Stewart, A.G. / Christie, M. |
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資金援助 | オーストラリア, 1件 組織 | 認可番号 | 国 |
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Australian Research Council (ARC) | DE160100608 | オーストラリア |
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引用 | ジャーナル: Rna / 年: 2023 タイトル: Molecular basis for GIGYF-TNRC6 complex assembly. 著者: Sobti, M. / Mead, B.J. / Stewart, A.G. / Igreja, C. / Christie, M. |
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履歴 | 登録 | 2021年8月18日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年8月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年3月15日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name |
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改定 1.2 | 2023年5月31日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.3 | 2023年10月25日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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