Entry | Database: PDB / ID: 7rtg |
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Title | Crystal Structure of the Human Adenosine Deaminase 1 |
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Components | Adenosine deaminase |
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Keywords | HYDROLASE / adenosine deaminase / zinc binding enzyme / holoenzyme |
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Function / homology | Function and homology information
purine nucleotide salvage / Defective ADA disrupts (deoxy)adenosine deamination / mature B cell apoptotic process / xanthine biosynthetic process / negative regulation of penile erection / negative regulation of mucus secretion / penile erection / positive regulation of germinal center formation / negative regulation of adenosine receptor signaling pathway / cytoplasmic vesicle lumen ...purine nucleotide salvage / Defective ADA disrupts (deoxy)adenosine deamination / mature B cell apoptotic process / xanthine biosynthetic process / negative regulation of penile erection / negative regulation of mucus secretion / penile erection / positive regulation of germinal center formation / negative regulation of adenosine receptor signaling pathway / cytoplasmic vesicle lumen / 2'-deoxyadenosine deaminase activity / inosine biosynthetic process / amide catabolic process / adenosine deaminase / germinal center B cell differentiation / purine-containing compound salvage / deaminase activity / adenosine catabolic process / adenosine deaminase activity / hypoxanthine salvage / deoxyadenosine catabolic process / dAMP catabolic process / adenosine metabolic process / positive regulation of T cell differentiation in thymus / AMP catabolic process / dATP catabolic process / mucus secretion / Ribavirin ADME / negative regulation of leukocyte migration / regulation of cell-cell adhesion mediated by integrin / response to purine-containing compound / embryonic digestive tract development / allantoin metabolic process / trophectodermal cell differentiation / Purine salvage / GMP salvage / positive regulation of smooth muscle contraction / Peyer's patch development / germinal center formation / negative regulation of mature B cell apoptotic process / AMP salvage / negative regulation of thymocyte apoptotic process / anchoring junction / positive regulation of alpha-beta T cell differentiation / alpha-beta T cell differentiation / positive regulation of heart rate / leukocyte migration / lung alveolus development / positive regulation of T cell receptor signaling pathway / thymocyte apoptotic process / B cell proliferation / smooth muscle contraction / : / positive regulation of calcium-mediated signaling / positive regulation of B cell proliferation / T cell activation / xenobiotic metabolic process / liver development / calcium-mediated signaling / placenta development / negative regulation of inflammatory response / T cell receptor signaling pathway / T cell differentiation in thymus / lysosome / cell adhesion / response to hypoxia / external side of plasma membrane / cell surface / zinc ion binding / membrane / plasma membrane / cytosolSimilarity search - Function Adenosine deaminase / Adenosine/AMP deaminase active site / Adenosine and AMP deaminase signature. / Adenosine deaminase domain / Adenosine deaminase / Adenosine/adenine deaminase / Metal-dependent hydrolaseSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.591 Å |
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Authors | Ma, M.T. / Lieberman, R.L. / Blazeck, J. / Jennings, M.R. |
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Funding support | United States, 1items Organization | Grant number | Country |
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Other private | NA | United States |
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Citation | Journal: Acta Crystallogr D Struct Biol / Year: 2022 Title: Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation. Authors: Ma, M.T. / Jennings, M.R. / Blazeck, J. / Lieberman, R.L. |
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History | Deposition | Aug 13, 2021 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jan 12, 2022 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 18, 2023 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id ..._struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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