登録情報 データベース : PDB / ID : 7rrc 構造の表示 ダウンロードとリンクタイトル IDO1 IN COMPLEX WITH COMPOUND 14 要素Indoleamine 2,3-dioxygenase 1 詳細 キーワード OXIDOREDUCTASE / INDOLEAMINE DIOXYGENASE / HEME / INHIBITOR機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
indoleamine 2,3-dioxygenase / smooth muscle contractile fiber / indoleamine 2,3-dioxygenase activity / positive regulation of chronic inflammatory response / kynurenic acid biosynthetic process / tryptophan 2,3-dioxygenase activity / positive regulation of T cell tolerance induction / tryptophan catabolic process to kynurenine / stereocilium bundle / positive regulation of type 2 immune response ... indoleamine 2,3-dioxygenase / smooth muscle contractile fiber / indoleamine 2,3-dioxygenase activity / positive regulation of chronic inflammatory response / kynurenic acid biosynthetic process / tryptophan 2,3-dioxygenase activity / positive regulation of T cell tolerance induction / tryptophan catabolic process to kynurenine / stereocilium bundle / positive regulation of type 2 immune response / 'de novo' NAD biosynthetic process from tryptophan / tryptophan catabolic process / Tryptophan catabolism / negative regulation of T cell apoptotic process / positive regulation of T cell apoptotic process / swimming behavior / negative regulation of interleukin-10 production / multicellular organismal response to stress / T cell proliferation / negative regulation of T cell proliferation / positive regulation of interleukin-12 production / female pregnancy / response to lipopolysaccharide / electron transfer activity / inflammatory response / heme binding / metal ion binding / cytoplasm / cytosol 類似検索 - 分子機能 Indoleamine 2,3-dioxygenase / Indoleamine 2,3-dioxygenase / Indoleamine 2,3-dioxygenase signature 1. / Indoleamine 2,3-dioxygenase signature 2. / Tryptophan/Indoleamine 2,3-dioxygenase-like 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.18 Å 詳細データ登録者 Lesburg, C.A. 資金援助 1件 詳細 詳細を隠す 引用ジャーナル : J.Med.Chem. / 年 : 2022タイトル : Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.著者: Li, D. / Sloman, D.L. / Achab, A. / Zhou, H. / McGowan, M.A. / White, C. / Gibeau, C. / Zhang, H. / Pu, Q. / Bharathan, I. / Hopkins, B. / Liu, K. / Ferguson, H. / Fradera, X. / Lesburg, C.A. ... 著者 : Li, D. / Sloman, D.L. / Achab, A. / Zhou, H. / McGowan, M.A. / White, C. / Gibeau, C. / Zhang, H. / Pu, Q. / Bharathan, I. / Hopkins, B. / Liu, K. / Ferguson, H. / Fradera, X. / Lesburg, C.A. / Martinot, T.A. / Qi, J. / Song, Z.J. / Yin, J. / Zhang, H. / Song, L. / Wan, B. / DAddio, S. / Solban, N. / Miller, J.R. / Zamlynny, B. / Bass, A. / Freeland, E. / Ykoruk, B. / Hilliard, C. / Ferraro, J. / Zhai, J. / Knemeyer, I. / Otte, K.M. / Vincent, S. / Sciammetta, N. / Pasternak, A. / Bennett, D.J. / Han, Y. 履歴 登録 2021年8月9日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2022年3月16日 Provider : repository / タイプ : Initial release改定 1.1 2022年5月11日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID
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