登録情報 | データベース: PDB / ID: 7rn2 |
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タイトル | Crystal structure of the first bromodomain of human BRD4 in complex with SJ001010551-2 |
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要素 | Bromodomain-containing protein 4 |
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キーワード | CELL CYCLE / bromodomain-containing protein 4 isoform long / BRD4 / bromodomain containing protein 4 / mitotic chromosome associated protein |
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機能・相同性 | 機能・相同性情報
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ...RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / : / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site ...Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / : / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.05 Å |
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データ登録者 | Stachowski, T.R. / Fischer, M. |
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引用 | ジャーナル: Eur.J.Med.Chem. / 年: 2023 タイトル: From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors. 著者: Koravovic, M. / Mayasundari, A. / Tasic, G. / Keramatnia, F. / Stachowski, T.R. / Cui, H. / Chai, S.C. / Jonchere, B. / Yang, L. / Li, Y. / Fu, X. / Hiltenbrand, R. / Paul, L. / Mishra, V. / ...著者: Koravovic, M. / Mayasundari, A. / Tasic, G. / Keramatnia, F. / Stachowski, T.R. / Cui, H. / Chai, S.C. / Jonchere, B. / Yang, L. / Li, Y. / Fu, X. / Hiltenbrand, R. / Paul, L. / Mishra, V. / Klco, J.M. / Roussel, M.F. / Pomerantz, W.C. / Fischer, M. / Rankovic, Z. / Savic, V. |
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履歴 | 登録 | 2021年7月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年8月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年8月16日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2023年10月18日 | Group: Refinement description / カテゴリ: pdbx_initial_refinement_model |
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