登録情報 | データベース: PDB / ID: 7rdt |
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タイトル | Structure of human NTHL1 - linker 1 chimera |
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要素 | Isoform 3 of Endonuclease III-like protein 1 |
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キーワード | HYDROLASE / Lyase / DNA Glycosylase |
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機能・相同性 | 機能・相同性情報
Defective NTHL1 substrate processing / Defective NTHL1 substrate binding / : / oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity / oxidized purine nucleobase lesion DNA N-glycosylase activity / base-excision repair, AP site formation / depyrimidination / DNA N-glycosylase activity / Displacement of DNA glycosylase by APEX1 / 加水分解酵素; 糖加水分解酵素; N-グリコシル化合物加水分解酵素 ...Defective NTHL1 substrate processing / Defective NTHL1 substrate binding / : / oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity / oxidized purine nucleobase lesion DNA N-glycosylase activity / base-excision repair, AP site formation / depyrimidination / DNA N-glycosylase activity / Displacement of DNA glycosylase by APEX1 / 加水分解酵素; 糖加水分解酵素; N-グリコシル化合物加水分解酵素 / DNA-(apurinic or apyrimidinic site) endonuclease activity / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / class I DNA-(apurinic or apyrimidinic site) endonuclease activity / DNA-(apurinic or apyrimidinic site) lyase / 4 iron, 4 sulfur cluster binding / double-stranded DNA binding / endonuclease activity / damaged DNA binding / mitochondrion / nucleoplasm / nucleus / metal ion binding類似検索 - 分子機能 Endonuclease III-like protein 1 / Endonuclease III-like, conserved site-2 / Endonuclease III family signature. / Helix-hairpin-helix motif / Endonuclease III-like, iron-sulphur cluster loop motif / FES / Helix-hairpin-helix motif / HhH-GPD superfamily base excision DNA repair protein / Helix-hairpin-helix, base-excision DNA repair, C-terminal / HhH-GPD domain ...Endonuclease III-like protein 1 / Endonuclease III-like, conserved site-2 / Endonuclease III family signature. / Helix-hairpin-helix motif / Endonuclease III-like, iron-sulphur cluster loop motif / FES / Helix-hairpin-helix motif / HhH-GPD superfamily base excision DNA repair protein / Helix-hairpin-helix, base-excision DNA repair, C-terminal / HhH-GPD domain / endonuclease III / DNA glycosylase類似検索 - ドメイン・相同性 IRON/SULFUR CLUSTER / Endonuclease III-like protein 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.1 Å |
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データ登録者 | Carroll, B.L. / Doublie, S. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | P01-CA098993 | 米国 |
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引用 | ジャーナル: Nucleic Acids Res. / 年: 2021 タイトル: Caught in motion: human NTHL1 undergoes interdomain rearrangement necessary for catalysis. 著者: Carroll, B.L. / Zahn, K.E. / Hanley, J.P. / Wallace, S.S. / Dragon, J.A. / Doublie, S. |
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履歴 | 登録 | 2021年7月11日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2021年12月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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