Entry Database : PDB / ID : 7ql7 Structure visualization Downloads & linksTitle Crystal structure of YTHDF1 YTH domain in complex with the ebsulfur derivative compound 9 ComponentsYTH domain-containing family protein 1 Details Keywords RNA BINDING PROTEIN / mRNA binding and stabilityFunction / homology Function and homology informationFunction Domain/homology Component
regulation of antigen processing and presentation / regulation of axon guidance / organelle assembly / N6-methyladenosine-containing RNA reader activity / regulation of long-term synaptic potentiation / immune system process / mRNA destabilization / positive regulation of translational initiation / stress granule assembly / regulation of mRNA stability ... regulation of antigen processing and presentation / regulation of axon guidance / organelle assembly / N6-methyladenosine-containing RNA reader activity / regulation of long-term synaptic potentiation / immune system process / mRNA destabilization / positive regulation of translational initiation / stress granule assembly / regulation of mRNA stability / learning / positive regulation of translation / P-body / memory / cytoplasmic stress granule / ribosome binding / mRNA binding / RNA binding / cytoplasm Similarity search - FunctionBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.3 Å DetailsAuthors Dalle Vedove, A. / Cazzanelli, G. / Quattrone, A. / Provenzani, A. / Lolli, G. Funding support Italy, 3items Details Hide detailsOrganization Grant number Country Italian Association for Cancer Research MFAG 2017 - ID 19882 Italy Italian Association for Cancer Research AIRC IG2018 - ID 21548 Italy Italian Association for Cancer Research AIRC IG2018 - ID 22075 Italy
CitationJournal : Acs Pharmacol Transl Sci / Year : 2022Title : Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6 -Methyladenosine-Modified RNAs.Authors: Micaelli, M. / Dalle Vedove, A. / Cerofolini, L. / Vigna, J. / Sighel, D. / Zaccara, S. / Bonomo, I. / Poulentzas, G. / Rosatti, E.F. / Cazzanelli, G. / Alunno, L. / Belli, R. / Peroni, D. / ... Authors : Micaelli, M. / Dalle Vedove, A. / Cerofolini, L. / Vigna, J. / Sighel, D. / Zaccara, S. / Bonomo, I. / Poulentzas, G. / Rosatti, E.F. / Cazzanelli, G. / Alunno, L. / Belli, R. / Peroni, D. / Dassi, E. / Murakami, S. / Jaffrey, S.R. / Fragai, M. / Mancini, I. / Lolli, G. / Quattrone, A. / Provenzani, A. History Deposition Dec 19, 2021 Deposition site : PDBE / Processing site : PDBERevision 1.0 Nov 23, 2022 Provider : repository / Type : Initial releaseRevision 1.1 Jan 31, 2024 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id ... _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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