登録情報 | データベース: PDB / ID: 7o4d |
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タイトル | QR2 inhibitor from a novel sulfanamide series to tackle age related oxidative stress and cognitive decline |
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要素 | Ribosyldihydronicotinamide dehydrogenase [quinone] |
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キーワード | OXIDOREDUCTASE / Inhibitors |
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機能・相同性 | 機能・相同性情報
ribosyldihydronicotinamide dehydrogenase (quinone) / dihydronicotinamide riboside quinone reductase activity / quinone catabolic process / resveratrol binding / oxidoreductase activity, acting on other nitrogenous compounds as donors / melatonin binding / NAD(P)H dehydrogenase (quinone) activity / Phase I - Functionalization of compounds / chloride ion binding / FAD binding ...ribosyldihydronicotinamide dehydrogenase (quinone) / dihydronicotinamide riboside quinone reductase activity / quinone catabolic process / resveratrol binding / oxidoreductase activity, acting on other nitrogenous compounds as donors / melatonin binding / NAD(P)H dehydrogenase (quinone) activity / Phase I - Functionalization of compounds / chloride ion binding / FAD binding / oxidoreductase activity / electron transfer activity / protein homodimerization activity / zinc ion binding / extracellular exosome / nucleoplasm / cytosol類似検索 - 分子機能 : / Flavodoxin-like fold / Flavodoxin-like fold / Flavoprotein-like superfamily類似検索 - ドメイン・相同性 FLAVIN-ADENINE DINUCLEOTIDE / Chem-V1Z / Ribosyldihydronicotinamide dehydrogenase [quinone]類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.249 Å |
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データ登録者 | Gould, N.L. / Scherer, G.R. / Carvalh, S. / Shurrush, K. / Edry, E. / Elkobi, A. / David, O. / Dym, O. / Albeck, S. / Peleg, Y. ...Gould, N.L. / Scherer, G.R. / Carvalh, S. / Shurrush, K. / Edry, E. / Elkobi, A. / David, O. / Dym, O. / Albeck, S. / Peleg, Y. / Germain, N. / Babaev, I. / Sharir, H. / Lefker, B. / Subramanyam, C. / Barr, H. / Rosenblum, K. |
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資金援助 | イスラエル, 1件 組織 | 認可番号 | 国 |
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Israel Science Foundation | 258/20 | イスラエル |
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引用 | ジャーナル: J.Clin.Invest. / 年: 2023 タイトル: Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice. 著者: Gould, N.L. / Scherer, G.R. / Carvalho, S. / Shurrush, K. / Kayyal, H. / Edry, E. / Elkobi, A. / David, O. / Foqara, M. / Thakar, D. / Pavesi, T. / Sharma, V. / Walker, M. / Maitland, M. / ...著者: Gould, N.L. / Scherer, G.R. / Carvalho, S. / Shurrush, K. / Kayyal, H. / Edry, E. / Elkobi, A. / David, O. / Foqara, M. / Thakar, D. / Pavesi, T. / Sharma, V. / Walker, M. / Maitland, M. / Dym, O. / Albeck, S. / Peleg, Y. / Germain, N. / Babaev, I. / Sharir, H. / Lalzar, M. / Shklyar, B. / Hazut, N. / Khamaisy, M. / Levesque, M. / Lajoie, G. / Avoli, M. / Amitai, G. / Lefker, B. / Subramanyam, C. / Shilton, B. / Barr, H. / Rosenblum, K. |
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履歴 | 登録 | 2021年4月6日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2022年8月17日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月31日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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改定 1.2 | 2024年2月28日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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