登録情報 | データベース: PDB / ID: 7n9h |
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タイトル | Structure of the mammalian importin a1 bound to the TDP-43 NLS |
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要素 | - Importin subunit alpha-1
- TAR DNA-binding protein 43
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キーワード | PROTEIN TRANSPORT / NUCLEAR IMPORT / IMPORTIN ALPHA / NLS / TDP-43 |
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機能・相同性 | 機能・相同性情報
Sensing of DNA Double Strand Breaks / nuclear inner membrane organization / regulation of DNA recombination / interchromatin granule / perichromatin fibrils / entry of viral genome into host nucleus through nuclear pore complex via importin / 3'-UTR-mediated mRNA destabilization / positive regulation of viral life cycle / NS1 Mediated Effects on Host Pathways / NLS-dependent protein nuclear import complex ...Sensing of DNA Double Strand Breaks / nuclear inner membrane organization / regulation of DNA recombination / interchromatin granule / perichromatin fibrils / entry of viral genome into host nucleus through nuclear pore complex via importin / 3'-UTR-mediated mRNA destabilization / positive regulation of viral life cycle / NS1 Mediated Effects on Host Pathways / NLS-dependent protein nuclear import complex / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / nuclear import signal receptor activity / DNA metabolic process / 3'-UTR-mediated mRNA stabilization / CaMK IV-mediated phosphorylation of CREB / intracellular non-membrane-bounded organelle / nuclear localization sequence binding / NLS-bearing protein import into nucleus / negative regulation by host of viral transcription / positive regulation of type I interferon production / pre-mRNA intronic binding / response to endoplasmic reticulum stress / RNA splicing / molecular condensate scaffold activity / negative regulation of protein phosphorylation / mRNA 3'-UTR binding / regulation of protein stability / positive regulation of insulin secretion / regulation of circadian rhythm / ISG15 antiviral mechanism / histone deacetylase binding / cytoplasmic stress granule / positive regulation of protein import into nucleus / mRNA processing / protein import into nucleus / SARS-CoV-1 activates/modulates innate immune responses / host cell / rhythmic process / regulation of gene expression / double-stranded DNA binding / nuclear membrane / regulation of apoptotic process / Estrogen-dependent gene expression / amyloid fibril formation / regulation of cell cycle / nuclear speck / RNA polymerase II cis-regulatory region sequence-specific DNA binding / Golgi membrane / negative regulation of gene expression / lipid binding / endoplasmic reticulum membrane / chromatin / SARS-CoV-2 activates/modulates innate and adaptive immune responses / mitochondrion / DNA binding / RNA binding / nucleoplasm / identical protein binding / membrane / nucleus / cytosol / cytoplasm類似検索 - 分子機能 : / TAR DNA-binding protein 43, C-terminal / TAR DNA-binding protein 43, N-terminal / TAR DNA-binding protein 43, N-terminal domain / Importin subunit alpha / Atypical Arm repeat / Importin-alpha, importin-beta-binding domain superfamily / Importin beta binding domain / Atypical Arm repeat / Importin-alpha, importin-beta-binding domain ...: / TAR DNA-binding protein 43, C-terminal / TAR DNA-binding protein 43, N-terminal / TAR DNA-binding protein 43, N-terminal domain / Importin subunit alpha / Atypical Arm repeat / Importin-alpha, importin-beta-binding domain superfamily / Importin beta binding domain / Atypical Arm repeat / Importin-alpha, importin-beta-binding domain / IBB domain profile. / Armadillo/plakoglobin ARM repeat profile. / Armadillo/beta-catenin-like repeat / Armadillo/beta-catenin-like repeats / Armadillo / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Armadillo-like helical / Armadillo-type fold / Nucleotide-binding alpha-beta plait domain superfamily類似検索 - ドメイン・相同性 Importin subunit alpha-1 / TAR DNA-binding protein 43類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.2 Å |
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データ登録者 | Doll, S.G. / Lokareddy, R.K. / Cingolani, G. |
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資金援助 | 米国, 5件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM122844 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R35GM140733 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | CA56036 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | OD017987 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | OD023479 | 米国 |
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引用 | ジャーナル: Cell Rep / 年: 2022 タイトル: Recognition of the TDP-43 nuclear localization signal by importin alpha 1/ beta. 著者: Doll, S.G. / Meshkin, H. / Bryer, A.J. / Li, F. / Ko, Y.H. / Lokareddy, R.K. / Gillilan, R.E. / Gupta, K. / Perilla, J.R. / Cingolani, G. |
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履歴 | 登録 | 2021年6月17日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年6月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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改定 1.2 | 2024年1月10日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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