Entry Database : PDB / ID : 7m2o Structure visualization Downloads & linksTitle Crystal structure of Human Glycolate Oxidase with Inhibitor Compound 15 ComponentsHydroxyacid oxidase 1 Details Keywords OXIDOREDUCTASEFunction / homology Function and homology informationFunction Domain/homology Component
glyoxylate oxidase / glyoxylate oxidase activity / glycolate catabolic process / (S)-2-hydroxy-acid oxidase / (S)-2-hydroxy-acid oxidase activity / fatty acid alpha-oxidation / Glyoxylate metabolism and glycine degradation / glycine biosynthetic process / peroxisomal matrix / Peroxisomal protein import ... glyoxylate oxidase / glyoxylate oxidase activity / glycolate catabolic process / (S)-2-hydroxy-acid oxidase / (S)-2-hydroxy-acid oxidase activity / fatty acid alpha-oxidation / Glyoxylate metabolism and glycine degradation / glycine biosynthetic process / peroxisomal matrix / Peroxisomal protein import / FMN binding / response to oxidative stress / intracellular membrane-bounded organelle / cytosol Similarity search - Function Alpha-hydroxy acid dehydrogenase, FMN-dependent / FMN-dependent alpha-hydroxy acid dehydrogenase, active site / FMN hydroxy acid dehydrogenase domain / FMN-dependent alpha-hydroxy acid dehydrogenases active site. / FMN-dependent alpha-hydroxy acid dehydrogenase domain profile. / FMN-dependent dehydrogenase / FMN-dependent dehydrogenase / Aldolase-type TIM barrel Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.07 Å DetailsAuthors Gumpena, R. / Ding, J. / Powell, D.A. / Lowther, W.T. CitationJournal : ACS Medicinal Chemistry Letters / Year : 2021Title : Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary HyperoxaluriaAuthors: Ding, J. / Gumpena, R. / Boily, M.O. / Caron, A. / Chong, O. / Cox, J.H. / Dumais, V. / Gaudreault, S. / Graff, A.H. / King, A. / Knight, J. / Oballa, R. / Surendradoss, J. / Tang, T. / Wu, ... Authors : Ding, J. / Gumpena, R. / Boily, M.O. / Caron, A. / Chong, O. / Cox, J.H. / Dumais, V. / Gaudreault, S. / Graff, A.H. / King, A. / Knight, J. / Oballa, R. / Surendradoss, J. / Tang, T. / Wu, J. / Lowther, W.T. / Powell, D.A. History Deposition Mar 17, 2021 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 14, 2021 Provider : repository / Type : Initial releaseRevision 1.1 Oct 18, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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