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- PDB-7lgl: Structural characterization of two b-KTx scorpion toxins. One of ... -
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Open data
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Basic information
Entry | Database: PDB / ID: 7lgl | ||||||
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Title | Structural characterization of two b-KTx scorpion toxins. One of them blocks human KCNQ1 potassium channels | ||||||
![]() | Potassium channel toxin TcoKIK | ||||||
![]() | TOXIN / B-KTx / NMR solution structure / scorpion toxins / cysteine-stabilized ab motif / TcoKIK / Beta-KTx14.3 / KCNQ1 / Kv7.1. | ||||||
Function / homology | Long chain scorpion toxin family / Potassium channel toxin / BetaSPN-type cysteine-stabilized alpha/beta (CS-alpha/beta) domain profile. / toxin activity / extracellular region / Potassium channel toxin TcoKIK![]() | ||||||
Biological species | ![]() | ||||||
Method | SOLUTION NMR / molecular dynamics | ||||||
![]() | del Rio-Portilla, F. / Lopez-Giraldo, A.E. | ||||||
![]() | ![]() Title: b-KTx scorpion toxin blocks human KCNQ1 potassium channels Authors: del Rio-Portilla, F. / Lopez-Giraldo, A.E. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 283.6 KB | Display | ![]() |
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PDB format | ![]() | 239.3 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 368.6 KB | Display | ![]() |
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Full document | ![]() | 435.6 KB | Display | |
Data in XML | ![]() | 15.3 KB | Display | |
Data in CIF | ![]() | 26.4 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data | |
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Other databases |
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein/peptide | Mass: 5294.156 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||
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NMR experiment |
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Sample preparation
Details | Type: solution / Contents: 1.2 mM TcoKIK, 95% H2O/5% D2O / Label: 1H_sample / Solvent system: 95% H2O/5% D2O |
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Sample | Conc.: 1.2 mM / Component: TcoKIK / Isotopic labeling: natural abundance |
Sample conditions | Ionic strength: 0 Not defined / Label: 1 / pH: 6.8 / Pressure: 1 atm / Temperature: 298 K |
-NMR measurement
NMR spectrometer | Type: Bruker AVANCE II / Manufacturer: Bruker / Model: AVANCE II / Field strength: 700 MHz |
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Processing
NMR software |
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Refinement | Method: molecular dynamics / Software ordinal: 1 | ||||||||||||||||||||
NMR representative | Selection criteria: lowest energy | ||||||||||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 200 / Conformers submitted total number: 20 |