登録情報 | データベース: PDB / ID: 7la5 |
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タイトル | Structure of human GGT1 in complex with Lnt1-172 compound. |
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要素 | (Glutathione hydrolase 1 ...) x 2 |
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キーワード | HYDROLASE / Substrate-ENZYME COMPLEX / NTN-HYDROLASE FAMILY / GLYCOPROTEIN / N-GLYCOSYLATION / CELL SURFACE |
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機能・相同性 | 機能・相同性情報
leukotriene-C4 hydrolase / peptidyltransferase activity / leukotriene-C(4) hydrolase / leukotriene D4 biosynthetic process / Defective GGT1 causes GLUTH / Defective GGT1 in aflatoxin detoxification causes GLUTH / LTC4-CYSLTR mediated IL4 production / Glutathione synthesis and recycling / peptide modification / gamma-glutamyltransferase ...leukotriene-C4 hydrolase / peptidyltransferase activity / leukotriene-C(4) hydrolase / leukotriene D4 biosynthetic process / Defective GGT1 causes GLUTH / Defective GGT1 in aflatoxin detoxification causes GLUTH / LTC4-CYSLTR mediated IL4 production / Glutathione synthesis and recycling / peptide modification / gamma-glutamyltransferase / glutathione gamma-glutamate hydrolase / glutathione hydrolase activity / leukotriene C4 gamma-glutamyl transferase activity / glutathione catabolic process / glutathione biosynthetic process / glutamate metabolic process / leukotriene metabolic process / Aflatoxin activation and detoxification / cysteine biosynthetic process / Synthesis of Leukotrienes (LT) and Eoxins (EX) / regulation of immune system process / Paracetamol ADME / amino acid metabolic process / zymogen activation / fatty acid metabolic process / regulation of inflammatory response / spermatogenesis / proteolysis / extracellular space / extracellular exosome / plasma membrane類似検索 - 分子機能 Gamma-glutamyltranspeptidase / Gamma-glutamyltranspeptidase signature. / Gamma-glutamyltranspeptidase / Gamma-glutamyltranspeptidase, large subunit, C-terminal domain / Gamma-glutamyltranspeptidase, small subunit / Nucleophile aminohydrolases, N-terminal類似検索 - ドメイン・相同性 Chem-XSM / Glutathione hydrolase 1 proenzyme類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 2.07 Å |
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データ登録者 | Terzyan, S.S. / Hanigan, M. / Nguen, L. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01GM125952 | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Structure of human GGT1 in complex with Lnt1-172 compound. 著者: Terzyan, S.S. / Hanigan, M. |
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履歴 | 登録 | 2021年1月5日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年1月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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