登録情報 データベース : PDB / ID : 7jul 構造の表示 ダウンロードとリンクタイトル Crystal structure of non phosphorylated PTEN (n-crPTEN-13sp-T1, SDTTDSDPENEG) 要素Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 詳細 キーワード TRANSFERASE / HYDROLASE / phosphatase / Phosphatidylinositol 3 / 4 / 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
PTEN Loss of Function in Cancer / phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase / inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity / negative regulation of keratinocyte migration / phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity / negative regulation of synaptic vesicle clustering / phosphatidylinositol phosphate phosphatase activity / rhythmic synaptic transmission / inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity / central nervous system myelin maintenance ... PTEN Loss of Function in Cancer / phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase / inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity / negative regulation of keratinocyte migration / phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity / negative regulation of synaptic vesicle clustering / phosphatidylinositol phosphate phosphatase activity / rhythmic synaptic transmission / inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity / central nervous system myelin maintenance / negative regulation of wound healing, spreading of epidermal cells / phosphatidylinositol-3-phosphate phosphatase activity / central nervous system neuron axonogenesis / postsynaptic density assembly / neuron-neuron synaptic transmission / presynaptic membrane assembly / synapse maturation / Regulation of PTEN mRNA translation / Negative regulation of the PI3K/AKT network / cellular response to electrical stimulus / negative regulation of cell cycle G1/S phase transition / negative regulation of axonogenesis / phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity / myelin sheath adaxonal region / Transcriptional Regulation by MECP2 / negative regulation of organ growth / negative regulation of excitatory postsynaptic potential / forebrain morphogenesis / negative regulation of focal adhesion assembly / phosphatidylinositol dephosphorylation / Schmidt-Lanterman incisure / anaphase-promoting complex binding / 加水分解酵素; エステル加水分解酵素; 1価のリン酸エステル加水分解酵素 / negative regulation of cyclin-dependent protein serine/threonine kinase activity / dentate gyrus development / positive regulation of ubiquitin protein ligase activity / ubiquitin ligase activator activity / spindle assembly involved in female meiosis / maternal behavior / positive regulation of ubiquitin-dependent protein catabolic process / phosphatidylinositol biosynthetic process / dendritic spine morphogenesis / negative regulation of cell size / negative regulation of epithelial to mesenchymal transition / regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / negative regulation of G1/S transition of mitotic cell cycle / protein serine/threonine phosphatase activity / adult behavior / molecular function inhibitor activity / myosin phosphatase activity / protein-serine/threonine phosphatase / ubiquitin-specific protease binding / Synthesis of IP3 and IP4 in the cytosol / negative regulation of peptidyl-serine phosphorylation / regulation of neuron projection development / locomotor rhythm / negative regulation of cellular senescence / Synthesis of PIPs at the plasma membrane / negative regulation of vascular associated smooth muscle cell proliferation / phosphoprotein phosphatase activity / social behavior / positive regulation of excitatory postsynaptic potential / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / multicellular organismal response to stress / canonical Wnt signaling pathway / prepulse inhibition / synapse assembly / protein dephosphorylation / phosphatidylinositol 3-kinase/protein kinase B signal transduction / Regulation of PTEN localization / protein-tyrosine-phosphatase / negative regulation of protein phosphorylation / negative regulation of cell migration / protein tyrosine phosphatase activity / cell projection / central nervous system development / cell motility / locomotory behavior / TP53 Regulates Metabolic Genes / PDZ domain binding / positive regulation of DNA-binding transcription factor activity / regulation of protein stability / PML body / cytoplasmic side of plasma membrane / Regulation of PTEN stability and activity / Ovarian tumor domain proteases / cell migration / negative regulation of neuron projection development / Downstream TCR signaling / heart development / dendritic spine / postsynaptic density / learning or memory / protein stabilization / Ub-specific processing proteases / neuron projection / apical plasma membrane / negative regulation of cell population proliferation / lipid binding / positive regulation of cell population proliferation 類似検索 - 分子機能 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN / PTEN, phosphatase domain / : / Inositol hexakisphosphate / Tensin phosphatase, C2 domain / Tensin-type phosphatase domain / C2 domain of PTEN tumour-suppressor protein / Phosphatase tensin-type domain profile. / C2 tensin-type domain profile. / C2 domain of PTEN tumour-suppressor protein ... Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN / PTEN, phosphatase domain / : / Inositol hexakisphosphate / Tensin phosphatase, C2 domain / Tensin-type phosphatase domain / C2 domain of PTEN tumour-suppressor protein / Phosphatase tensin-type domain profile. / C2 tensin-type domain profile. / C2 domain of PTEN tumour-suppressor protein / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Protein-tyrosine phosphatase, active site / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / C2 domain superfamily 類似検索 - ドメイン・相同性 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / フーリエ合成 / 解像度 : 2.53 Å 詳細データ登録者 Dempsey, D. / Phan, K. / Cole, P. / Gabelli, S.B. 資金援助 米国, 3件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Cancer Institute (NIH/NCI) CA74305 米国 Department of Defense (DOD, United States) 米国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) K99GM130961 米国
引用ジャーナル : Nat.Struct.Mol.Biol. / 年 : 2021タイトル : The structural basis of PTEN regulation by multi-site phosphorylation.著者 : Dempsey, D.R. / Viennet, T. / Iwase, R. / Park, E. / Henriquez, S. / Chen, Z. / Jeliazkov, J.R. / Palanski, B.A. / Phan, K.L. / Coote, P. / Gray, J.J. / Eck, M.J. / Gabelli, S.B. / Arthanari, H. / Cole, P.A. 履歴 登録 2020年8月20日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2021年8月11日 Provider : repository / タイプ : Initial release改定 2.0 2022年2月2日 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Database references / Derived calculations / Refinement description / Source and taxonomy / Structure summary カテゴリ : atom_site / citation ... atom_site / citation / entity / entity_name_com / entity_src_gen / pdbx_contact_author / pdbx_nonpoly_scheme / pdbx_poly_seq_scheme / pdbx_struct_sheet_hbond / pdbx_unobs_or_zero_occ_residues / pdbx_validate_close_contact / pdbx_validate_torsion / refine / refine_hist / refine_ls_restr / refine_ls_shell / struct_conf / struct_sheet / struct_sheet_order / struct_sheet_range Item : _citation.title / _entity.pdbx_description ... _citation.title / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity_name_com.name / _entity_src_gen.gene_src_common_name / _pdbx_contact_author.id / _pdbx_poly_seq_scheme.auth_mon_id / _pdbx_poly_seq_scheme.auth_seq_num / _pdbx_poly_seq_scheme.pdb_mon_id / _refine.B_iso_max / _refine.B_iso_mean / _refine.B_iso_min / _refine.aniso_B[1][1] / _refine.aniso_B[2][2] / _refine.aniso_B[3][3] / _refine.correlation_coeff_Fo_to_Fc_free / _refine.ls_R_factor_R_free / _refine.ls_R_factor_R_work / _refine.ls_R_factor_obs / _refine.ls_number_reflns_R_free / _refine.ls_number_reflns_obs / _refine.ls_percent_reflns_R_free / _refine.ls_percent_reflns_obs / _refine.ls_wR_factor_R_free / _refine.ls_wR_factor_R_work / _refine.overall_FOM_work_R_set / _refine.overall_SU_B / _refine.overall_SU_ML / _refine.overall_SU_R_Cruickshank_DPI / _refine.overall_SU_R_free / _refine.pdbx_overall_ESU_R / _refine.pdbx_overall_ESU_R_Free / _refine_hist.number_atoms_solvent / _refine_hist.number_atoms_total / _refine_hist.pdbx_B_iso_mean_solvent / _refine_hist.pdbx_number_atoms_protein / _refine_hist.pdbx_number_residues_total / _refine_ls_restr.dev_ideal / _refine_ls_restr.number / _refine_ls_shell.R_factor_R_free / _refine_ls_shell.R_factor_R_work / _refine_ls_shell.d_res_low / _refine_ls_shell.number_reflns_R_free / _refine_ls_shell.number_reflns_R_work / _refine_ls_shell.percent_reflns_obs 解説 : Model orientation/position詳細 : We uploaded an older pdb of the initial refinements;Provider : author / タイプ : Coordinate replacement改定 2.1 2022年3月2日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 2.2 2023年10月18日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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