Entry | Database: PDB / ID: 7jm4 |
---|
Title | IRF Transcription Factor |
---|
Components | - (Interferon-Stimulated Response Elements) x 2
- Interferon regulatory factor 4
|
---|
Keywords | TRANSCRIPTION / DNA-bound transcription factor |
---|
Function / homology | Function and homology information
T-helper 17 cell lineage commitment / negative regulation of toll-like receptor signaling pathway / regulation of T-helper cell differentiation / positive regulation of interleukin-13 production / myeloid dendritic cell differentiation / immune system process / positive regulation of interleukin-4 production / defense response to protozoan / positive regulation of interleukin-10 production / Nuclear events stimulated by ALK signaling in cancer ...T-helper 17 cell lineage commitment / negative regulation of toll-like receptor signaling pathway / regulation of T-helper cell differentiation / positive regulation of interleukin-13 production / myeloid dendritic cell differentiation / immune system process / positive regulation of interleukin-4 production / defense response to protozoan / positive regulation of interleukin-10 production / Nuclear events stimulated by ALK signaling in cancer / T cell activation / positive regulation of interleukin-2 production / Interferon gamma signaling / nucleosome / sequence-specific double-stranded DNA binding / Interferon alpha/beta signaling / positive regulation of cold-induced thermogenesis / DNA-binding transcription activator activity, RNA polymerase II-specific / Interleukin-4 and Interleukin-13 signaling / sequence-specific DNA binding / transcription coactivator activity / DNA-binding transcription factor activity, RNA polymerase II-specific / chromatin remodeling / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / nucleoplasm / membrane / nucleus / cytosolSimilarity search - Function Interferon regulatory factor-3 / Interferon-regulatory factor 3 / Interferon-regulatory factor 3 / Interferon regulatory factor, conserved site / IRF tryptophan pentad repeat DNA-binding domain signature. / Interferon regulatory factor transcription factor / interferon regulatory factor / IRF tryptophan pentad repeat DNA-binding domain profile. / Interferon regulatory factor DNA-binding domain / SMAD-like domain superfamily ...Interferon regulatory factor-3 / Interferon-regulatory factor 3 / Interferon-regulatory factor 3 / Interferon regulatory factor, conserved site / IRF tryptophan pentad repeat DNA-binding domain signature. / Interferon regulatory factor transcription factor / interferon regulatory factor / IRF tryptophan pentad repeat DNA-binding domain profile. / Interferon regulatory factor DNA-binding domain / SMAD-like domain superfamily / SMAD/FHA domain superfamily / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamilySimilarity search - Domain/homology |
---|
Biological species | Homo sapiens (human) |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.95 Å |
---|
Authors | Sundararaj, S. / Williams, S.J. / Casarotto, M.G. |
---|
Funding support | Australia, 1items Organization | Grant number | Country |
---|
National Health and Medical Research Council (NHMRC, Australia) | APP1126201 | Australia |
|
---|
Citation | Journal: Nucleic Acids Res. / Year: 2021 Title: Structural determinants of the IRF4/DNA homodimeric complex. Authors: Sundararaj, S. / Seneviratne, S. / Williams, S.J. / Enders, A. / Casarotto, M.G. |
---|
History | Deposition | Jul 31, 2020 | Deposition site: RCSB / Processing site: RCSB |
---|
Revision 1.0 | Mar 24, 2021 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Oct 18, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|