- PDB-7g13: Crystal Structure of human FABP4 binding site mutated to that of ... -
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基本情報
登録情報
データベース: PDB / ID: 7g13
タイトル
Crystal Structure of human FABP4 binding site mutated to that of FABP5 in complex with 4-[[3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]carbamoyl]-3,6-dihydro-2H-pyran-5-carboxylic acid
要素
Fatty acid-binding protein, adipocyte
キーワード
LIPID BINDING PROTEIN / FATTY ACID BINDING PROTEIN / CYTOPLASM / LIPID-BINDING / TRANSPORT / PROTEIN BINDING
機能・相同性
機能・相同性情報
hormone receptor binding / long-chain fatty acid transmembrane transporter activity / cellular response to lithium ion / long-chain fatty acid binding / Triglyceride catabolism / white fat cell differentiation / fatty acid transport / long-chain fatty acid transport / brown fat cell differentiation / lipid droplet ...hormone receptor binding / long-chain fatty acid transmembrane transporter activity / cellular response to lithium ion / long-chain fatty acid binding / Triglyceride catabolism / white fat cell differentiation / fatty acid transport / long-chain fatty acid transport / brown fat cell differentiation / lipid droplet / cholesterol homeostasis / fatty acid binding / response to bacterium / Transcriptional regulation of white adipocyte differentiation / positive regulation of inflammatory response / cellular response to tumor necrosis factor / positive regulation of cold-induced thermogenesis / negative regulation of DNA-templated transcription / extracellular exosome / nucleus / cytoplasm / cytosol 類似検索 - 分子機能
構造決定の手法: 分子置換 開始モデル: inhouse model 解像度: 1.15→42.73 Å / Cor.coef. Fo:Fc: 0.976 / Cor.coef. Fo:Fc free: 0.965 / SU B: 1.501 / SU ML: 0.03 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R: 0.041 / ESU R Free: 0.043 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD 詳細: density and refine B-values identify pyran-3-carboxylic acid. no para- regioisomer possible N-terminus clashes with symmetry equivalent - case of dropping space group symmetry because of a ...詳細: density and refine B-values identify pyran-3-carboxylic acid. no para- regioisomer possible N-terminus clashes with symmetry equivalent - case of dropping space group symmetry because of a few atoms - not warranted.
Rfactor
反射数
%反射
Selection details
Rfree
0.1981
2156
5.1 %
RANDOM
Rwork
0.1579
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obs
0.1599
39948
94.34 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK