Entry Database : PDB / ID : 7euw Structure visualization Downloads & linksTitle X-ray structure of high-strength hydrogel-grown FABP3 crystal soaked in 50% DMSO solution containing 4-[2-[1-(4-bromophenyl)-5-phenyl-1H-pyrazol-3-yl]phenoxy] (HA174) ComponentsFatty acid-binding protein, heart Details Keywords LIPID BINDING PROTEIN / FABP / Complex / Binding protein / HA174Function / homology Function and homology informationFunction Domain/homology Component
positive regulation of long-chain fatty acid import into cell / regulation of phosphatidylcholine biosynthetic process / regulation of fatty acid oxidation / positive regulation of phospholipid biosynthetic process / intracellular lipid transport / oleic acid binding / phospholipid homeostasis / long-chain fatty acid binding / long-chain fatty acid transport / Triglyceride catabolism ... positive regulation of long-chain fatty acid import into cell / regulation of phosphatidylcholine biosynthetic process / regulation of fatty acid oxidation / positive regulation of phospholipid biosynthetic process / intracellular lipid transport / oleic acid binding / phospholipid homeostasis / long-chain fatty acid binding / long-chain fatty acid transport / Triglyceride catabolism / brown fat cell differentiation / cytoskeletal protein binding / cholesterol homeostasis / negative regulation of cell population proliferation / extracellular space / extracellular exosome / nucleus / cytosol Similarity search - Function Cytosolic fatty-acid binding proteins signature. / Intracellular lipid binding protein / Cytosolic fatty-acid binding / Lipocalin / cytosolic fatty-acid binding protein family / Lipocalin/cytosolic fatty-acid binding domain / Calycin Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.55 Å DetailsAuthors Sugiyama, S. / Kakinouchi, K. / Nakano, R. / Matsuoka, S. / Tsuchikawa, H. / Sonoyama, M. / Inoue, Y. / Hayashi, F. / Murata, M. Funding support Japan, 4items Details Hide detailsOrganization Grant number Country Japan Society for the Promotion of Science (JSPS) 19K06588 Japan Japan Science and Technology JPMJTM19DC Japan Other private 09-003-005 Japan Japan Science and Technology JPMJER1005 Japan
CitationJournal : To Be Published Title : X-ray structure of the human heart fatty acid-binding protein complexed with 4-[2-[1-(4-bromophenyl)-5-phenyl-1H-pyrazol-3-yl]phenoxy] (HA176)Authors : Sugiyama, S. / Kakinouchi, K. / Matsuoka, S. / Tsuchikawa, H. / Sonoyama, M. / Inoue, Y. / Hayashi, F. / Murata, M. History Deposition May 19, 2021 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 May 25, 2022 Provider : repository / Type : Initial releaseRevision 1.1 Nov 29, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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