登録情報 | データベース: PDB / ID: 7eod |
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タイトル | MITF HLHLZ Delta AKE |
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要素 | Isoform M1 of Microphthalmia-associated transcription factor |
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キーワード | TRANSCRIPTION / TRANSCRIPTION FACTOR |
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機能・相同性 | 機能・相同性情報
canonical Wnt signaling pathway involved in negative regulation of apoptotic process / positive regulation of DNA-templated transcription initiation / regulation of RNA biosynthetic process / regulation of osteoclast differentiation / melanocyte differentiation / bone remodeling / camera-type eye development / E-box binding / SUMOylation of transcription factors / cell fate commitment ...canonical Wnt signaling pathway involved in negative regulation of apoptotic process / positive regulation of DNA-templated transcription initiation / regulation of RNA biosynthetic process / regulation of osteoclast differentiation / melanocyte differentiation / bone remodeling / camera-type eye development / E-box binding / SUMOylation of transcription factors / cell fate commitment / osteoclast differentiation / negative regulation of cell migration / DNA-binding transcription repressor activity, RNA polymerase II-specific / regulation of cell population proliferation / protein-containing complex assembly / DNA-binding transcription activator activity, RNA polymerase II-specific / protein dimerization activity / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / chromatin binding / positive regulation of gene expression / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 Microphthalmia-associated transcription factor / MiT/TFE transcription factors, C-terminal / MiT/TFE transcription factors, N-terminal / Domain of unknown function (DUF3371) / MITF/TFEB/TFEC/TFE3 N-terminus / Helix-loop-helix DNA-binding domain / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile.類似検索 - ドメイン・相同性 Microphthalmia-associated transcription factor類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.9 Å |
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データ登録者 | Li, P. / Liu, Z. / Fang, P. / Wang, J. |
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資金援助 | 中国, 4件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | 21778064 | 中国 | National Natural Science Foundation of China (NSFC) | 21778067 | 中国 | National Natural Science Foundation of China (NSFC) | 21977108 | 中国 | National Natural Science Foundation of China (NSFC) | 21977107 | 中国 |
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引用 | ジャーナル: Cell Res. / 年: 2023 タイトル: A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. 著者: Liu, Z. / Chen, K. / Dai, J. / Xu, P. / Sun, W. / Liu, W. / Zhao, Z. / Bennett, S.P. / Li, P. / Ma, T. / Lin, Y. / Kawakami, A. / Yu, J. / Wang, F. / Wang, C. / Li, M. / Chase, P. / Hodder, P. ...著者: Liu, Z. / Chen, K. / Dai, J. / Xu, P. / Sun, W. / Liu, W. / Zhao, Z. / Bennett, S.P. / Li, P. / Ma, T. / Lin, Y. / Kawakami, A. / Yu, J. / Wang, F. / Wang, C. / Li, M. / Chase, P. / Hodder, P. / Spicer, T.P. / Scampavia, L. / Cao, C. / Pan, L. / Dong, J. / Chen, Y. / Yu, B. / Guo, M. / Fang, P. / Fisher, D.E. / Wang, J. |
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履歴 | 登録 | 2021年4月22日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2022年4月27日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年9月20日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2023年11月29日 | Group: Refinement description / カテゴリ: pdbx_initial_refinement_model |
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