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-基本情報
登録情報 | データベース: PDB / ID: 7ekt | ||||||
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タイトル | human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 and PNU-120596 | ||||||
要素 | Neuronal acetylcholine receptor subunit alpha-7 | ||||||
キーワード | MEMBRANE PROTEIN / alpha 7 / nicotinic acetylcholine receptor / agonist / PAM | ||||||
機能・相同性 | 機能・相同性情報 sensory processing / dendrite arborization / response to acetylcholine / Highly calcium permeable postsynaptic nicotinic acetylcholine receptors / acetylcholine-gated channel complex / regulation of amyloid fibril formation / short-term memory / positive regulation of CoA-transferase activity / acetylcholine receptor activity / dendritic spine organization ...sensory processing / dendrite arborization / response to acetylcholine / Highly calcium permeable postsynaptic nicotinic acetylcholine receptors / acetylcholine-gated channel complex / regulation of amyloid fibril formation / short-term memory / positive regulation of CoA-transferase activity / acetylcholine receptor activity / dendritic spine organization / chloride channel regulator activity / acetylcholine binding / regulation of amyloid precursor protein catabolic process / acetylcholine-gated monoatomic cation-selective channel activity / acetylcholine receptor signaling pathway / positive regulation of amyloid-beta formation / negative regulation of amyloid-beta formation / plasma membrane raft / modulation of excitatory postsynaptic potential / response to amyloid-beta / positive regulation of excitatory postsynaptic potential / negative regulation of tumor necrosis factor production / toxic substance binding / monoatomic ion transport / monoatomic ion transmembrane transport / positive regulation of protein metabolic process / positive regulation of long-term synaptic potentiation / synapse organization / response to nicotine / calcium channel activity / memory / cognition / intracellular calcium ion homeostasis / positive regulation of angiogenesis / calcium ion transport / monoatomic ion channel activity / amyloid-beta binding / postsynaptic membrane / postsynapse / positive regulation of MAPK cascade / positive regulation of ERK1 and ERK2 cascade / learning or memory / response to hypoxia / neuron projection / positive regulation of protein phosphorylation / synapse / positive regulation of cell population proliferation / signal transduction / protein homodimerization activity / membrane / plasma membrane 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) | ||||||
手法 | 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.02 Å | ||||||
データ登録者 | Liu, S. / Zhao, Y. / Sun, D. / Tian, C. | ||||||
引用 | ジャーナル: Cell Res / 年: 2021 タイトル: Structural basis of human α7 nicotinic acetylcholine receptor activation. 著者: Yue Zhao / Sanling Liu / Yingxin Zhou / Mengge Zhang / Haopeng Chen / H Eric Xu / Demeng Sun / Lei Liu / Changlin Tian / | ||||||
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-構造の表示
ムービー |
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構造ビューア | 分子: MolmilJmol/JSmol |
-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 7ekt.cif.gz | 365.4 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb7ekt.ent.gz | 303.6 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 7ekt.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/ek/7ekt ftp://data.pdbj.org/pub/pdb/validation_reports/ek/7ekt | HTTPS FTP |
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-関連構造データ
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-集合体
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