登録情報 | データベース: PDB / ID: 7bi5 |
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タイトル | Human CA II in complex with benzyl alcohol |
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要素 | Carbonic anhydrase 2 |
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キーワード | LYASE / Benzyl alcohol / primary alcohol / inhibitor complex |
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機能・相同性 | 機能・相同性情報
positive regulation of cellular pH reduction / positive regulation of dipeptide transmembrane transport / regulation of monoatomic anion transport / secretion / cyanamide hydratase / cyanamide hydratase activity / arylesterase activity / regulation of chloride transport / Reversible hydration of carbon dioxide / angiotensin-activated signaling pathway ...positive regulation of cellular pH reduction / positive regulation of dipeptide transmembrane transport / regulation of monoatomic anion transport / secretion / cyanamide hydratase / cyanamide hydratase activity / arylesterase activity / regulation of chloride transport / Reversible hydration of carbon dioxide / angiotensin-activated signaling pathway / positive regulation of synaptic transmission, GABAergic / morphogenesis of an epithelium / regulation of intracellular pH / carbonic anhydrase / carbonate dehydratase activity / carbon dioxide transport / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / neuron cellular homeostasis / one-carbon metabolic process / apical part of cell / myelin sheath / extracellular exosome / zinc ion binding / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Carbonic anhydrase, alpha-class, conserved site / Alpha-carbonic anhydrases signature. / Carbonic anhydrase, alpha-class / Alpha carbonic anhydrase domain / Alpha carbonic anhydrase domain superfamily / Eukaryotic-type carbonic anhydrase / Alpha-carbonic anhydrases profile. / Eukaryotic-type carbonic anhydrase類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / フーリエ合成 / 解像度: 1.74 Å |
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データ登録者 | Alterio, V. / De Simone, G. |
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資金援助 | イタリア, 1件 組織 | 認可番号 | 国 |
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Italian Ministry of Education | 201744BNST | イタリア |
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引用 | ジャーナル: Biochem.Biophys.Res.Commun. / 年: 2021 タイトル: Benzyl alcohol inhibits carbonic anhydrases by anchoring to the zinc coordinated water molecule. 著者: De Simone, G. / Bua, S. / Supuran, C.T. / Alterio, V. |
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履歴 | 登録 | 2021年1月12日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2021年3月17日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月31日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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