登録情報 | データベース: PDB / ID: 7aym |
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タイトル | Structure of DDR2 Kinase domain in complex with IBZ3 |
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要素 | Discoidin domain-containing receptor 2,Epithelial discoidin domain-containing receptor 1 |
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キーワード | MEMBRANE PROTEIN / Kinase / Receptor Tyrosine kinase Discoidin domain-containing receptor 2 / collagen / signal transduction / cell communication |
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機能・相同性 | 機能・相同性情報
positive regulation of hepatic stellate cell proliferation / protein tyrosine kinase collagen receptor activity / biomineral tissue development / smooth muscle cell-matrix adhesion / positive regulation of extracellular matrix disassembly / chondrocyte proliferation / positive regulation of hepatic stellate cell activation / endochondral bone growth / regulation of extracellular matrix disassembly / regulation of cell-matrix adhesion ...positive regulation of hepatic stellate cell proliferation / protein tyrosine kinase collagen receptor activity / biomineral tissue development / smooth muscle cell-matrix adhesion / positive regulation of extracellular matrix disassembly / chondrocyte proliferation / positive regulation of hepatic stellate cell activation / endochondral bone growth / regulation of extracellular matrix disassembly / regulation of cell-matrix adhesion / ear development / negative regulation of hydrogen peroxide-mediated programmed cell death / collagen-activated tyrosine kinase receptor signaling pathway / regulation of bone mineralization / positive regulation of fibroblast migration / cellular response to angiotensin / positive regulation of vascular associated smooth muscle cell migration / collagen fibril organization / branching involved in mammary gland duct morphogenesis / regulation of tissue remodeling / wound healing, spreading of cells / smooth muscle cell migration / neuron projection extension / positive regulation of wound healing / axon development / Non-integrin membrane-ECM interactions / positive regulation of collagen biosynthetic process / positive regulation of protein kinase activity / mammary gland alveolus development / positive regulation of G1/S transition of mitotic cell cycle / positive regulation of osteoblast differentiation / peptidyl-tyrosine autophosphorylation / positive regulation of vascular associated smooth muscle cell proliferation / cellular response to transforming growth factor beta stimulus / collagen binding / response to muscle stretch / lactation / embryo implantation / transmembrane receptor protein tyrosine kinase activity / ossification / regulation of cell growth / receptor protein-tyrosine kinase / positive regulation of DNA-binding transcription factor activity / positive regulation of neuron projection development / peptidyl-tyrosine phosphorylation / positive regulation of fibroblast proliferation / actin cytoskeleton / cellular response to hypoxia / cell population proliferation / protein autophosphorylation / receptor complex / cell adhesion / apical plasma membrane / negative regulation of cell population proliferation / focal adhesion / negative regulation of apoptotic process / signal transduction / extracellular space / extracellular exosome / ATP binding / metal ion binding / plasma membrane類似検索 - 分子機能 : / Discoidin domain-containing receptor 1/2, DS-like domain / Coagulation factors 5/8 type C domain (FA58C) signature 2. / Coagulation factors 5/8 type C domain (FA58C) signature 1. / Coagulation factor 5/8 C-terminal domain, discoidin domain / Coagulation factors 5/8 type C domain (FA58C) profile. / F5/8 type C domain / Coagulation factor 5/8 C-terminal domain / Tyrosine-protein kinase, receptor class II, conserved site / Receptor tyrosine kinase class II signature. ...: / Discoidin domain-containing receptor 1/2, DS-like domain / Coagulation factors 5/8 type C domain (FA58C) signature 2. / Coagulation factors 5/8 type C domain (FA58C) signature 1. / Coagulation factor 5/8 C-terminal domain, discoidin domain / Coagulation factors 5/8 type C domain (FA58C) profile. / F5/8 type C domain / Coagulation factor 5/8 C-terminal domain / Tyrosine-protein kinase, receptor class II, conserved site / Receptor tyrosine kinase class II signature. / Galactose-binding-like domain superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 Chem-4VD / Epithelial discoidin domain-containing receptor 1 / Discoidin domain-containing receptor 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.12 Å |
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データ登録者 | Nawrotek, A. / Talagas, A. / Vuillard, L.M. / Miallau, L. |
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引用 | ジャーナル: To Be Published タイトル: Structure of DDR2 Kinase domain in complex with IBZ3 著者: Nawrotek, A. / Talagas, A. / Vuillard, L.M. / Miallau, L. |
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履歴 | 登録 | 2020年11月12日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2020年12月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月31日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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